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Digitale Medien

Effects of thyroid status on clonidine-induced hypo-activity responses in the developing rat (1984)

Heal, D. J. ; Smith, S. D. L. ; Atterwill, C. K.

Springer

Journal of neural transmission 60 (1984), S. 295-302

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Details

ISSN: 1435-1463

Schlagwort(e): Adrenoceptors ; clonidine hypoactivity ; developing brain ; thyroid hormone

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Clonidine-induced hypoactivity was studied in rats made neonatally hypo- and hyperthyroid (PTU or T4 administered between 1–27 days postnatally) as an indication of central presynapticα 2-adrenoceptor function. Paradoxically, at 28 days postnatally both treatments caused an increase in clonidine-hypoactivity compared with untreated control animals, which was not due to sex differences amongst littermates in the various groups. It is proposed that whereas the hyperthyroid neonate data perhaps reflect an enhancement of presynapticα 2 function similar to that seen in the adult rat brain, the result obtained for the hypothyroid neonates could perhaps be due to a retardation of the ontogeny of central noradrenergic neurones.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01249101

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