ISSN:
1432-0428
Schlagwort(e):
Phenformin
;
metformin
;
glibenclamide
;
blood glucose
;
lactate
;
alanine
;
pyruvate
;
ketone bodies
;
maturity-onset diabetes
;
diabetic control
;
gluconeogenesis
;
glycerol
;
insulin
;
triglycerides
;
growth hormone
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary Twelve hour metabolic rhythms have been performed on six maturity-onset diabetic subjects during successive periods of therapy with phenformin, metformin, and glibenclamide. Moderate control of blood glucose concentration was achieved with phenformin and metformin, the lowest concentrations being found with glibenclamide. Mean blood lactate concentration was grossly elevated during phenformin therapy, moderately elevated with metformin and normal during glibenclamide treatment. Similar patterns were found for the lactate/pyruvate ratio, alanine, glycerol and ketone bodies. Serum triglyceride concentrations were significantly higher during phenformin treatment than with the other two regimes. Serum insulin concentration was higher on glibenclamide than with either biguanide. Most of these effects of the biguanides could be accounted for by an inhibitory effect on hepatic gluconeogenesis. It is concluded that the use of biguanides as hypoglycaemic agents in diabetes is associated with the production of multiple metabolic abnormalities.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00745143
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