ISSN:
1432-1106
Schlagwort(e):
Ventromedial thalamus
;
Superior colliculus
;
Apomorphine
;
Muscimol
;
Metenkephalin
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary Unilateral destruction of the ventromedial thalamus (VMT) with a radiofrequency lesion attenuated turning induced by injection of muscimol (40 ng/0.4 μl) but not of a metenkephalin-analogue (DAME; 2.5 μg/0.4 μl) into the substantia nigra, pars reticulata (SNR). Unilateral lesions in the deep layers of the superior colliculus (DLSC) attenuated both muscimol- and DAME-induced turning. Lesions in the DLSC but not in the VMT blocked the sensitization of the perioral biting reflex by injection of muscimol or DAME into the SNR on the same side of the lesion. When injected with apomorphine (0.5 mg/kg) all rats with lesions turned ipsiversive to the lesion side and reacted to tactile stimulation of the perioral area on both sides with orienting towards and then biting into the stimulus probe.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00235274
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