ZIB

Treffer pro Seite

Treffer 1 - 2 | 2 Treffer

Sortierung

Digitale Medien

Mutation of p53 with loss of heterozygosity in the osteosarcomatous component of a dedifferentiated chondrosarcoma (2000)

Grote, H. J. ; Schneider-Stock, Regine ; Neumann, W. ; [weitere]

Springer

Virchows Archiv 436 (2000), S. 494-497

zur Merkliste hinzufügen auf der Merkliste

Details

ISSN: 1432-2307

Schlagwort(e): Key words Dedifferentiated chondrosarcoma ; p53 mutation ; p53 LOH

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract We investigated a dedifferentiated chondrosarcoma of a 61-year-old woman with an osteosarcomatous high-grade component for p53 alteration. The low-grade cartilaginous and the high-grade osteosarcomatous components of the tumor were macrodissected and evaluated separately by immunohistochemistry and molecular biology. We used PCR-SSCP analysis and direct sequencing to screen exons 4–8 for p53 mutations. The p53 intron 1-polymorphism was investigated for loss of heterozygosity. A functionally relevant p53 missense mutation in codon 193 of exon 6 (A-to-T transversion) with loss of wild-type allele was detected only in the dedifferentiated component. Using the monoclonal antibody DO-1, immunohistochemistry failed to show p53 overexpression. This evidence of p53 mutation may be regarded as at least a co-factor that ”switched” the preexisting low-grade conventional chondrosarcoma to a highly malignant dedifferentiated tumor.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s004280050478

Permalink

Bibliothek	Standort	Signatur	Band/Heft/Jahr	Verfügbarkeit

Andere fanden auch interessant ...

Artikel (Nationallizenzen)

Volltext

Digitale Medien

Recent Developments in Organotin Chemistry (1963)

Neumann, W. P. ; Burkhardt, G. ; Heymann, E. ; [weitere]

Weinheim : Wiley-Blackwell

Angewandte Chemie International Edition in English 2 (1963), S. 165-175

zur Merkliste hinzufügen auf der Merkliste

Details

ISSN: 0570-0833

Schlagwort(e): Organotin compounds ; Chemistry ; General Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: New synthetic methods developed in the field of organotin compounds since 1959 are reviewed. The use of alkyl aluminum compounds brings an advance in the preparation of tetraalkyltin derivatives, alkyltin halides, and alkyltin hydrides. Organotin hydrides offer new possibilities for the production of monomeric and polymeric organotin compounds. Diethyltin and diphenyltin, which are obtained by catalytic dehydrogenation of the respective dialkyltin dihydrides, are cyclic compounds. - The literature since 1959 is reviewed.

Zusätzliches Material: 2 Ill.