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Digitale Medien

Genetic variation of an acid phosphatase (Acp-2) in the laboratory rat: Possible homology with mouse AP-1 and human ACP2 (1986)

Bender, K. ; Bissbort, S. ; Kuhn, A. ; [weitere]

Springer

Biochemical genetics 24 (1986), S. 1-11

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Details

ISSN: 1573-4927

Schlagwort(e): Rattus norvegicus ; acid phosphatases ; genetic variation ; linkage studies

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Chemie und Pharmazie

Notizen: Abstract A genetic locus controlling the electrophoretic mobility of an acid phosphatase in the rat (Rattus norvegicus) is described. The locus, designed Acp-2, is not expressed in erythrocytes but is expressed in all other tissues studied. The product of Acp-2 hydrolyzes a wide variety of phosphate monoesters and is inhibited by l(+)-tartaric acid. Inbred rat strains have fixed either allele Acp-2a or allele Acp-2b. Codominant expression is observed in the respective F1 hybrids. Backcross progenies revealed the expected 1:1 segregation ratio. Possible loose linkage was found between the Acp-2 and the Pep-3 gene loci at a recombination frequency of 0.36±0.06.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00502974

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