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  • 1
    Digitale Medien
    Digitale Medien
    On an implementation of standard bases and syzygies in SINGULAR (1996)
    Springer
    Applicable algebra in engineering, communication and computing 7 (1996), S. 235-249 
    Details
    ISSN: 1432-0622
    Schlagwort(e): Standard bases ; Syzygies ; Computer algebra system ; Highest corner ; EcartMethod
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Informatik , Mathematik , Technik allgemein
    Notizen: Abstract We describe an implementation of a general standard basis algorithm, valid for any monomial ordering compatible with the natural semigroup structure. We concentrate on new strategies which have proved useful, in particular in the non-wellordering case. Moreover, we describe the first implementation of Schreyer's method to compute syzygies and compare it with other, more classical methods. Comparisons of the computing time of several examples in the system SINGULAR give hints as to which strategies should be used in different classes of examples.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01190332
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  • 2
    Digitale Medien
    Digitale Medien
    Mutation of p53 with loss of heterozygosity in the osteosarcomatous component of a dedifferentiated chondrosarcoma (2000)
    Springer
    Virchows Archiv 436 (2000), S. 494-497 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Key words Dedifferentiated chondrosarcoma ; p53 mutation ; p53 LOH
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  We investigated a dedifferentiated chondrosarcoma of a 61-year-old woman with an osteosarcomatous high-grade component for p53 alteration. The low-grade cartilaginous and the high-grade osteosarcomatous components of the tumor were macrodissected and evaluated separately by immunohistochemistry and molecular biology. We used PCR-SSCP analysis and direct sequencing to screen exons 4–8 for p53 mutations. The p53 intron 1-polymorphism was investigated for loss of heterozygosity. A functionally relevant p53 missense mutation in codon 193 of exon 6 (A-to-T transversion) with loss of wild-type allele was detected only in the dedifferentiated component. Using the monoclonal antibody DO-1, immunohistochemistry failed to show p53 overexpression. This evidence of p53 mutation may be regarded as at least a co-factor that ”switched” the preexisting low-grade conventional chondrosarcoma to a highly malignant dedifferentiated tumor.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004280050478
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