ISSN:
1432-1041
Schlagwort(e):
Diazepam
;
diazepam metabolites
;
conjugates
;
biliary excretion
;
renal excretion
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
,
Medizin
Notizen:
Summary The concentration of free and conjugated diazepam, of its major demethylated metabolite, N-demethyldiazepam, and of its hydroxylated metabolites, N-methyloxazepam and oxazepam, were measured by a GLC-method in plasma, bile and urine following four nightly doses of diazepam 10 mg. Ten patients with a T-tube in the common bile duct after choledochotomy (Group I) were studied and 12 patients after cholecystectomy (Group II). Twelve hours after drug administration, the mean total concentration of diazepam in bile was 1/23 that in plasma. Similarly, during 9–10 h only low concentrations of diazepam were found in the urine, and in both urine and bile only the unconjugated drug was found. The principal metabolite of diazepam in plasma was N-demethyldiazepam. In bile an average of 77% of the total amount of N-demethyldiazepam was in the conjugated form, and its total concentration was half that in plasma. In urine N-demethyldiazepam was mainly in the conjugated form. No hydroxylated metabolites of diazepam were found in plasma. Oxazepam was the metabolite found in bile and urine in the next highest concentration after N-demethyldiazepam. In the urine it was mainly conjugated, but in bile only a mean of 35% was conjugated. Both in bile and urine, N-methyloxazepam was found only intermittently and in low concentration. Diazepam and all of its common metabolites were measured in human bile, and the concentrations found were too low to produce a clinically significant enterohepatic circulation.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00609863
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