ISSN:
1432-1041
Schlagwort(e):
diazepam
;
dipotassiumchlorazepate
;
benzodiazepines
;
bioavailability
;
administration
;
healthy volunteers
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
,
Medizin
Notizen:
Summary Dipotassium chlorazepate (DPC) and diazepam (DZM) were given i.m. and i.v. to 6 healthy volunteers in doses of 20 mg (48.9 µmol) DPC and 15 mg (52.0 µmol) DZM. The interval between the injections was at least 1 week. Plasma samples were analyzed for DPC and DZM by HPLC. The bioavailability of DPC and DZM after i.m. administration, determined from computer calculated AUCs, was 1.04 and 0.85, respectively.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00609698
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