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  • 1
    Digitale Medien
    Digitale Medien
    Effect of ampicillin on mefloquine pharmacokinetics in thai males (1991)
    Springer
    European journal of clinical pharmacology 40 (1991), S. 631-633 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Mefloquine ; ampicillin ; Thai subjects ; pharmacokinetics ; enterohepatic recycling ; drug interaction ; adverse effects
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The kinetics of a single oral dose of mefloquine given either alone or with ampicillin has been studied in 8 healthy Thai male volunteers. There was a significantly higher maximum whole blood mefloquine concentration after coadministration with ampicillin (1648 vs 1228 ng·ml−1), as well as a significantly reduced terminal half life (15.3 vs 17.7 days), mean residence time (20.1 vs 23.4 days) and volume of distribution at steady state (14.1 vs 19.4 l·kg−1). Although there was no significant change in the AUC from zero time to infinity, the AUC from zero time to 5 days was significantly increased by ampicillin (4.86 vs 3.27 μg·ml−1 day). These changes in mefloquine disposition after antibiotic treatment may be due both to an increase in fractional bioavailability and a reduction in the enterohepatic recycling of mefloquine.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00279985
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  • 2
    Digitale Medien
    Digitale Medien
    Effect of tetracycline on mefloquine pharmacokinetics in Thai males (1992)
    Springer
    European journal of clinical pharmacology 43 (1992), S. 567-569 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Mefloquine ; Tetracycline ; Thai subjects ; Thai subjects ; drug interaction ; pharmacokinetics ; adverse effects
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The kinetics of a single oral dose of mefloquine given either alone or with tetracycline has been studied in 20 healthy Thai male volunteers. There was a significantly higher maximum whole blood mefloquine concentration after coadministration with tetracycline (1600 vs 1160 ng · ml−1), as well as a significantly reduced terminal half-life (14.4 vs 19.3 days), mean residence time (11.9 vs 16.0 days) and volume of distribution at steady state (13.3 vs 19.91 · kg−1). Although there was no significant change in the AUC from zero time to infinity, the AUC from zero time to 7 days was significantly increased by tetracycline (6.18 vs 4.76 μg · ml−1 · day). The changes in mefloquine disposition after tetracycline treatment are probably due to a reduction in enterohepatic recycling. The initial increase in mefloquine AUC without an apparent increase in side-effects suggests that this combination may have a place in the treatment of multi-drug resistant falciparum malaria.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02285105
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  • 3
    Digitale Medien
    Digitale Medien
    Pharmacokinetics of mefloquine in the presence of primaquine (1992)
    Springer
    European journal of clinical pharmacology 42 (1992), S. 559-560 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Mefloquine ; Thai subjects ; pharmacokinetics ; Primaquine ; drug interaction ; adverse effects
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00314870
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  • 4
    Digitale Medien
    Digitale Medien
    Effectiveness factor calculations for immobilized enzyme catalysts (1973)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 15 (1973), S. 879-888 
    Details
    ISSN: 0006-3592
    Schlagwort(e): Chemistry ; Biochemistry and Biotechnology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: The steady state, nonlinear diffusion equations which describe reactions in constrained enzyme solutions are of great interest in many biological and engineering applications. As in other types of nonlinear differential equations, exact analytical solutions do not exist except in some simplified cases. In this paper, a general procedure is presented for solving numerically for the substrate concentration profile and effectiveness factor utilizing the transformation method suggested by Na and Na. Design correlations for enzyme solutions constrained within spherical membranes are included. The use of a unique definition of the Thiele Modulus in these charts permits the clear illustration of the effects of substrate concentration and external mass transfer resistances on the overall effectiveness factor for the catalyst particle.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/bit.260150505
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  • 5
    Digitale Medien
    Digitale Medien
    Water solubility of regioselectively 2,3-O-substituted carboxymethylcellulose (1997)
    Weinheim : Wiley-Blackwell
    Macromolecular Rapid Communications 18 (1997), S. 921-925 
    Details
    ISSN: 1022-1336
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Physik
    Notizen: A series of 2,3-O-carboxymethylcelluloses (CMC's), which are regioselectively substituted at the C-2 and C-3 position, were prepared and their water solubility was examined. It was found that the lower limit for the degree of substitution (DS) value of water-soluble 2,3-O-CMC is about 0.3. This value was almost the same as that of CMC prepared in a slurry of isopropyl alcohol/water with isopropyl chloroacetate and sodium hydroxide, showing that the uniform alkylation is rather important to convert cellulose into water-soluble derivatives.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/marc.1997.030181005
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  • 6
    Digitale Medien
    Digitale Medien
    Graft copolymer of gelatin/butyl acrylate and its use in the dye transferring blank film (1989)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 38 (1989), S. 2171-2182 
    Details
    ISSN: 0021-8995
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Maschinenbau , Physik
    Notizen: Butyl acrylate was graft copolymerized onto gelatin using ceric ammonium nitrate as redox initiator. A series of grafted products with various gelatin-to-butyl acrylate ratios were prepared. The molecular weight of the grafted side chains and the number of grafting sites were measured. The possible grafting sites on gelatin macromolecules were pointed out through amino acid analysis. The electron micrograph and DSC analysis showed that the grafted chain (PBA) and backbone gelatin were in separated phases. The graft copolymer was used in the receiving layer of the dye transfer blank film, and the photographic, dye transfer printing, and some physicomechanical properties were studied with satisfactory results.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/app.1989.070381202
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  • 7
    Digitale Medien
    Digitale Medien
    Solvent effects on the nitrogen screening of some nitroalkanes (1981)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 16 (1981), S. 57-59 
    Details
    ISSN: 0030-4921
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: High precision 14N screening measurements are presented for some nitroalkanes. The screening increases as the dielectric constant of the solvent decreases in all cases considered. The β effect on the nitrogen screening is found to be largely independent of solvent, and is thus an intrinsic property of the nitroalkanes. Good agreement is obtained between the observed solvent effects on nitrogen screening and those calculated by the SOS procedure using INDO/S parameters. It is concluded that the measured nitrogen screening changes monitor the electronic changes which occur in the nitroalkanes as the medium is changed.
    Zusätzliches Material: 1 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/mrc.1270160115
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  • 8
    Digitale Medien
    Digitale Medien
    Some calculations of solvent effects on 17O and 19F chemical shifts (1980)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 14 (1980), S. 92-97 
    Details
    ISSN: 0030-4921
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Sum-over-states perturbation and finite perturbation calculations, within the ‘Solvaton’ model, are presented for the variation of some 17O and 19F chemical shifts as a function of the dielectric constant of the medium. In general, the nuclear screening and charge are predicted to increase as the dielectric constant increases. The effects of hydrogen bonding are included by means of minimum energy dimer models in some of the sum-over-states calculations.
    Zusätzliches Material: 3 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/mrc.1270140204
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  • 9
    Digitale Medien
    Digitale Medien
    Some INDO/S—SOS calculations of the effects of hydrogen bonding on the nitrogen shielding of some heterocycles (1983)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 21 (1983), S. 501-504 
    Details
    ISSN: 0030-4921
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Some INDO/S parameterized SOS shielding calculations are reported for the nitrogen nuclei of some N-heterocycles. Hydrogen bonding with H2O and CF3CH2OH is incorporated in a supermolecule approach. The calculated effects of hydrogen bonding are found to be in satisfactory agreement with observed nitrogen shielding variations upon a change of solvent.
    Zusätzliches Material: 1 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/omr.1270210810
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  • 10
    Digitale Medien
    Digitale Medien
    Identification of an atypical constitutent of a clandestine opiate (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 350-351 
    Details
    ISSN: 1052-9306
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: An unusual morphine analog was extracted and separated from an opium-like sample. The high resolution mass spectrum of the unknown substance confirmed the empirical formula as C17H18O2NCl. Mass spectra and retention factor values in thin-layer chromatography of both unknown and authentic standards were compared, which lead to the identification of the unknown as β-chloromorphide.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/bms.1200010511
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