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Acetylator polymorphism in rheumatoid arthritis (1993)

Ladero, J. M. ; Andres, M. P. ; Bañares, A. ; [weitere]

Springer

European journal of clinical pharmacology 45 (1993), S. 279-281

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Details

ISSN: 1432-1041

Schlagwort(e): Rheumatoid arthritis ; Acetylator phenotype ; polymorphism ; sulphamethazine

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary Acetylator phenotype has been determined with sulphamethazine (sulphadimidine) in 69 Spanish patients with rheumatoid arthritis (48 females), all of whom were on second line therapy, and in 96 age-matched normal controls (54 females). Thirty-two patients (46.4%) and 56 controls (58.3%) were classified as slow acetylators. On analysing separately the females in both groups, 37.5% of patients and 63% of controls were found to be slow acetylators. No difference was found in the males (patients 66.3% and controls 52.4% slow acetylators). Rapid acetylator phenotype may be a risk factor for the development of severe rheumatoid arthritis in women.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00315397

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