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Digitale Medien

Depletion of membrane phospholipid and mitochondrial dysfunction associated with coronary reperfusion (1985)

Hattori, M. ; Ogawa, K. ; Satake, T. ; [weitere]

Springer

Basic research in cardiology 80 (1985), S. 241-250

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ISSN: 1435-1803

Schlagwort(e): phospholipase ; phospholipids ; mitochondria ; reperfusion injury ; canine heart

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary The role of phospholipase (PLase) in the development of heart mitochondrial dysfunction following reperfusion was studied together with the effects of dilazep on the action of PLases and reperfusion injury. In vivo experiment: Seventy six adult mongrel dogs were divided into 3 groups; the control group (n=36), the dilazep 0.5 mg group (n=17) and the dilazep 1 mg group (n=23). Fifteen min after premedication with physiological saline or dilazep (0.5 mg/kg or 1 mg/kg), the left anterior descending coronary artery was occluded for 15 min and then reperfused for 5 min. Each group was further divided into two subgroups depending on the presence or absence of reperfusion arrhythmia. Immediately after 5 min of reperfusion, myocardial mitochondria were prepared from the normal and the reperfused areas. Pretreatment with dilazep induced a dose-dependent decrease in the incidence of reperfusion arrhythmia from 31% of the control to 24% (0.5 mg/kg) and 9% (1 mg/kg). In the arrhythmia cases in each group, functional deterioration of mitochondria from the reperfused area was observed with the increase in free fatty acids and the decrease in phospholipids in the reperfused mitochondria. In vitro experiment: Using L-α-dimyristoyl phosphatidylcholine as a substrate, myristic acid released by PLase A2 or by PLase C with or without pretreatment by dilazep was quantitatively determined. Dilazep inhibited the release of myristic acid by PLase A2 or by PLase C in a concentration-dependent manner. These results suggest that decomposition of mitochondrial membrane phospholipids caused by PLase activation following reperfusion was primarily responsible for the development of mitochondrial dysfunction, and that dilazep showed beneficial effects against reperfusion injury by inhibiting the action of PLases.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01907900

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Digitale Medien

Applicability of Friedman plot (1986)

Ozawa, T.

Springer

Journal of thermal analysis and calorimetry 31 (1986), S. 547-551

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ISSN: 1572-8943

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie

Beschreibung / Inhaltsverzeichnis: Zusammenfassung Durch Erweiterung der ursprünglichen Gleichung wird gezeigt, daß die Friedman-Methode zur Bestimmung der Aktivierungsenergie chemischer Reaktionen unter Verwendung sowohl der Konversion als auch der Geschwindigkeit in thermoanalytischen Daten breite Anwendungsmöglichkeiten auf dem Gebiet des Wachstums von Kristallen aus Keimen, der Diffusion und anderer aus nur einem Grundprozeß bestehenden Vorgänge bietet.

Kurzfassung: Резюме Расширением первона чального уравнения, показано, что метод Фр идмэна для установления энерги и активации химическ их реакций с использованием пара метров превращения и скорос ти в термоаналитичес ких данных широко применимо к пр оцессу роста кристаллов на основе существующих центро в кристаллизации, к про цессу диффузии и друг им процессам, в которых и меет место единствен ный процесс.

Notizen: Abstract By expanding the initial equation, it is shown that the Friedman method for estimating the activation energy of chemical reactions by using both the conversion and the rate in the thermoanalytical data has wide applicability to crystal growth from pre-existing nuclei, diffusion and other processes in which a single unit process is involved.