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Digitale Medien

Axonal pathology of the skin in infantile neuroaxonal dystrophy (1987)

Kimura, S. ; Sasaki, Y. ; Warlo, I. ; [weitere]

Springer

Acta neuropathologica 75 (1987), S. 212-215

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Details

ISSN: 1432-0533

Schlagwort(e): Infantile neuroaxonal dystrophy ; Skin ; Dystrophic axons ; Terminal axons

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Ultrastructural studies on the skin of two patients affected by infantile neuroaxonal dystrophy (INAD) were performed to evaluate its diagnostic value and to discuss the etiology of INAD. While the majority of terminal axons around intradermal glands were dystophic consisting of tubulomembranous and tubulovesicular profiles sometimes accompanied by synaptic vesicles, there were only few dystophic axons inside intradermal nerve bundles. These observations suggest that the primary lesion of INAD is located in terminal and presynaptic axons. Therefore, terminal axons have to be investigated when a diagnostic skin biopsy is performed in INAD.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00687084

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