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  • 1
    Digitale Medien
    Digitale Medien
    A Monoclonal Antibody, H2, Defines a New Surface Antigen Expressed on Human Lymphocytes (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 30 (1989), S. 0 
    Details
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: We have previously described a monoclonal antibody (MoAb), H2, which recognized a tumour-unique antigen on a human T-cell chronic lymphatic leukaemia (T-CLL, CD3,4+). However further characterization of H2 has revealed a reactivity with the majority of T lymphocytes and a minority of B lymphocytes, some malignant T cells and a few cell lines of leukaemia or of hematopoietic tumour origin. The molecular weight of the antigen (80,000) precipitated by the MoAb H2 from the cell lines NALM-6 and Reh corresponded to that previously found. When PBL were stimulated with PHA, IL-2, or Con A a reduced reactivity of H2 could be seen. The MoAb H2 was submitted to the Fourth International Conference on Human Leucocyte Differentiation Antigens, Vienna, 1989. H2 did not cluster in any of the 78 flusters of differentiation (CD 1–78) discussed at the conference, indicating its unique reactivity. This suggests that we have defined a new antigen on lymphocytes with a possible role along the resting proliferating axis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-3083.1989.tb02464.x
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  • 2
    Digitale Medien
    Digitale Medien
    Enhancement of Human Immunodeficiency Virus (HIV) Replication in Human Monocytes by Low Titres of Anti-HIV Antibodies in Vitro (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 30 (1989), S. 0 
    Details
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Low concentrations of serum obtained from a patient with acquired immunodeficiency syndrome (AIDS) enhanced the replication of human immunodeficiency virus type 1 (HIV-1) in a particular subclone of the CD4-positive monocytoid cell line U937 clone 2. Cells of this subclone have a high expression of Fc receptors and a considerable degree of Fc-mediated phagocytic activity. IgG purified from the serum was also able to enhance the replication. These results indicate that low concentrations of human anti-HIV antibody may enhance HIV replication on human monocyte macrophages. Furthermore, two mouse IgG1 monoclonal antibodies against gp120, the envelope glycoprotein of HIV-1, also induced enhancement at low concentrations. The binding of radiolabelled gp120 to the cells was increased at the same low concentrations. Antibodies against envelope glycoproteins may cause enhancement of HIV infection. Both normal and enhanced replication of HIV were completely inhibited by the masking of the binding site of CD4 molecules with F(ab')2 fragments of anti-CD4 antibody. Moreover, CD4-positive, FcγRI-negative K562 cells and mouse macrophages failed to show any infection in the presence of antibody. These results suggest that CD4 molecules on the cell surface are necessary to cause enhancement of infection of HIV on monocyte macrophages.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-3083.1989.tb02446.x
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  • 3
    Digitale Medien
    Digitale Medien
    A New Surface Antigen on Human Lymphocytes Defined by the Murine Monoclonal Antibody IVF7 (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 31 (1990), S. 0 
    Details
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The murine monoclonal antibody (MoAb) IVF7 was produced against tumour cells from a patient with a CD 3+, CD4+, CD8− T-cell chronic lymphatic leukaemia (T-CLL). The MoAb IVF7 showed reactivity with subpopulations of normal peripheral blood lymphocytes (PBL), as well as with a few cell lines of haematopoietic origin. Thirty-six percent of PBL were stained with IVF7. Analysing subpopulations, we found that 80% of NK cells, 25% of T cells, and 10–20% of B cells were positive. The myelomonocytic cell line KG-1 was also stained. The molecular weight of the molecule was 40 kDa under reducing conditions. The antigen was found to be trypsinsensitive.MoAb IVF7 could modulate the antigen from the cell surface. The antibody did not stimulate PBL to DNA synthesis, nor did it significantly lnfluence NK cell-mediaied kilting.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-3083.1990.tb02793.x
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  • 4
    Digitale Medien
    Digitale Medien
    Certain Human Gpl20-HIV Antibodies React with Anti-CD4 Antibodies (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 27 (1988), S. 0 
    Details
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: HIV+ human sera contain antibodies against most HIV proteins, including the envelope glycoprotein Gpl20. Some of these antibodies may have an epitope that sterically resembles the CD4 region to which the Gp120 molecule binds. Amongst 58 HIV+ sera tested, we found three with the capacity to block the binding of anti-CD4 monoclonal antibodies to CD4+ cells. The serum with the highest blocking capacity was selected for further analysis. The inhibitor was shown to be an antibody that binds to the Gp120 molecule as well us to the anti-CD4 monoclonal T4.2. These CD4-mimicking antibodies were shown not to interfere with CD4-dependent reactions in vitro. Virus neutralizing experiments in vitro could not show any neutralizing effect with these antibodies alone. The HIV+ individual providing this antibody is still healthy, although HIV since 1983.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-3083.1988.tb02328.x
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  • 5
    Digitale Medien
    Digitale Medien
    Three Kinds of Tumour-Unique Surface Molecules on a Human T-Cell Chronic Lymphocytic Leukaemia (T-CLL) Detected by Monoclonal Antibodies (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 26 (1987), S. 0 
    Details
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Mouse monoclonai antibodies recognizing cell surface molecules on tumour cells from a patient with a T-cetl chronic lymphatic lcukacmia (T-CLL) have been produced. Three different types of idiotype-like cell Surface structures were identified. One molecule had a relative molecular weight (Mr) of 90,000 under non-reduced conditions and of 42,000 upon reduction, which corresponds well to the T-cell receptor for antigen (Tt). The two other molecules, which also behaved like unique tumour markers, have not previously been described, to our knowledge. One molecule wasa monomer with an Mr, of 74,000–80,000 when non-reduced and 80,000 upon reduction. The other idiotypic molecule was a dimer with a non-reduced Mr of 74,000–80,000, and 38,000 after reduction.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-3083.1987.tb02257.x
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  • 6
    Digitale Medien
    Digitale Medien
    The Effect of Tunicamycin on Target Cell Susceptibility to Natural Killer Cell Cytotoxicity (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 25 (1987), S. 0 
    Details
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Several sets of data indicate the possibility that carbohydrate moieties on the target cell are important structures in natural killer (NK) cell-mediated lysis. Strkining changes in the NK susceptibility of targets can be induced in several systems involving in vitro differentiation of tumour cell lines. The effect on target cells of the glycosylation inhibitor tunicamycin, which acts by blocking the dolichol-dependent asparagine-linked glvcosvlation pathway was investigated. Using several different tumour cell lines we can conclude that; (a) asparagine-linked carbohydrate chains do not contribute directly to NK susceptibility, (b) induced differentiation may or may not be linked with a change in NK susceptibility, and (c) secondary changes caused by tunicamycin treatment may lead to alterations in the gangliosides, a finding that is positvely correlated with decreased NK susceptibility.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-3083.1987.tb01058.x
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  • 7
    Digitale Medien
    Digitale Medien
    Selective Inhibition of IgE versus β2-Microglobulin in Human U-266 Myeloma Cell Line Treated with T-Cell-Derived Factors (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 22 (1985), S. 0 
    Details
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Concanavalin-A-activated T cells and their crude supernatant were assayed for suppressivc activity un an IgE-producing U-266 cell line. Delectable and comparable degrees of suppression were obtained with the co-culture and the supernatant protocols. Separation of the effector population into T4+ and TS+ subsets showed the most effective cells in the T8+ fraction. Control experiments demonstrated that the IgE down-regulation was selective, since parallel measurement of β2-microglobulin synthesis showed no effect of T cells or T-cell-derived supernatants. In addition, several human T-cell lymphoma-leukaemia virus I-transformed T-cell lines were explored for their capacity to produce factor(s) able to suppress IgE synthesis in the U-266 cell line, and four out of 25 cell lines could be shown to do this in a constitutive manner. Kinetic studies suggested that the inhibition occurred at a transcriptional level, The results indicate that the T-cell-mycloma system is an interesting model to define belter the regulation of IgE in the human.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-3083.1985.tb01857.x
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  • 8
    Digitale Medien
    Digitale Medien
    Functional Characterization of Hapten-Specific Suppressor Cells (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 22 (1985), S. 0 
    Details
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: T cells From animals suppressed against a given hapten, trinitrophenyl (TNP), were analysed for their capacity to inhibit the humoral B-cell response against the hapten and/or a complex antigen, horse erythrocytes (HRBC), coupled or not 10 the hapten. As expected, suppression of the response to HRBC in all experiments required coupling to TNP. However, the suppressing capacity of the T cells varied with the stage of the B cells, with no detectable suppression occurring if already primed carrier-specific B cells were used. Hapten-specific T helper cells could, however, be induced in hapten-suppressed mice, when hapten-carrier conjugates were used as immunogen. Under these conditions normal efficiency of induction of carrier-specific T helper cells was observed, and this probably also applied to hapten-specific T helper cells to the same extent. This assumption was strengthened by using the hapten-binding capacity of the suppressor T cells and Lyt-l/2-specific sera to subdivide physically helper and suppressor function.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-3083.1985.tb01861.x
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  • 9
    Digitale Medien
    Digitale Medien
    Specific IgM Enhances and IgG Inhibits the Induction of Immunological Memory in Mice (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 21 (1985), S. 0 
    Details
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The effect of priming mice with IgM anti-SRBC (sheep erythrocytes) together with SRBC or IgG anti-SRBC together with SRBC on the development and expression of memory cells was studied. Mice primed with specific IgM and SRBC showed a much more efficient secondary plaque-forming cell and serum antibody response after challenge with SRBC in an adoptive transfer system than did controls primed with SRBC only. The expression of this enhanced memory of IgM-primed spleen cells was counteracted by the high levels of internal IgG anti-SRBC (also the result of priming with IgM) when the mice, instead of being tested in adoptive transfers, were challenged directly. The antigen-specific feedback suppression of the primary antibody response by specific IgG antibodies was also seen to inhibit partially the development of memory cells. The suppressive effect on priming could be demonstrated both in adoptive transfer systems and after direct boost of the same mice thai received the primary immunization. Both the IgM enhancement and the IgG suppression of memory cell development were antigen-specific, since no effect on the antibody response to a non-cross-reacting antigen, horse erythrocytes, was seen. The effect of these up- or down-regulations of immunological memory could be demonstrated after secondary injections as long as 90–280 days alter priming.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-3083.1985.tb01428.x
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  • 10
    Digitale Medien
    Digitale Medien
    Relationships between HLA-DR-expressing Cells and T Lymphocytes of Different Subsets in Rheumatoid Synovial Tissue (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 15 (1982), S. 0 
    Details
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: An immunohistochemical double staining technique was used to study the relationships between HLA-DR-expressing, mostly macrophage-like cells, and different populations of T lymphocytes in frozen sections of synovial tissue from patients with Inflammatory joint disease, particularly rheumatoid arthritis. Substantial T-lymphocyte infiltration as measured by Leu I antibody binding was found, especially adjacent to HLA-DR-expressing cells near the synovial cavity and around small vessels. Most of the T cells reacted with Leu 3a ('helper/inducer'-cell-specific) antibodies, whereas relatively few cells were Leu 2a (cytotoxic/suppressor’ T-cell-specific)-positive.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-3083.1982.tb00676.x
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