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  • Electronic Resource  (12)
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  • Electronic Resource  (12)
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  • 11
    Electronic Resource
    Electronic Resource
    Role of interferons in cell differentiation and development (1991)
    Springer
    Cytotechnology 5 (1991), S. 152-157 
    Details
    ISSN: 1573-0778
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Interferons (IFNs), besides inducing an antiviral state in uninfected cells, are also natural regulatory molecules. They play a key role in the regulation both of cell growth and differentiation, and of development. Up-or down-regulation of oncogenes by IFNs may be one of the mechanisms by which these molecules affect cell physiology. The list of IFN-inducible proteins continues to grow rapidly and future research should identify among these the mediators of the biological effects of IFNs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00736836
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    Paper (German National Licenses)
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  • 12
    Electronic Resource
    Electronic Resource
    Reduced maturation of friend virus in adhesive mutants of friend leukemia cells (1987)
    Springer
    Archives of virology 92 (1987), S. 151-164 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The replication of Friend Leukemia virus (FLV) has been investigated in adhesive clones (FF) of Friend Leukemia cells which were selected via cultivation on top of human fibroblast monolayers. In these adhesive clones a shut-down of FLV production is observed under conditions of culture confluency; this finding is not due either to a reduced number of cell divisions nor to a defective expression of FLV genome as assessed by Northern blot and immunofluorescence studies. Ultrastructural studies showed that virus budding and release into the medium is not detectable under these conditions. Conversely, in confluent FF cell monolayers abundant imperfect type-A enveloped particles were visible, possibly originating from stacks of granular endoplasmic reticulum with thickened membranes. It is postulated that the reduced virus production in adhesive FF monolayers is due to as yet undetermined events taking place during virus maturation at a time coincident with that of cell-cell adhesion under conditions of culture confluency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01310069
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    Paper (German National Licenses)
    Fulltext
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