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  • 11
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Decision sciences 27 (1996), S. 0 
    ISSN: 1540-5915
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: This paper develops a general integer programming model for strategic, area-wide contingency planning of oil spill cleanup operations. Model inputs include the set of risk points and the likely spill scenarios and response requirements for each, the sites of existing storage locations and the inventory of components at each, and potential sites for new storage locations. The model prescribes a minimum total cost plan to either build new storage locations, expand existing ones, or both, to purchase new components and pre-position them, and a contingency plan that determines which response systems should be composed to enable an effective time-phased response for each likely spill scenario. A family of heuristics based on linear programming (LP) is devised to resolve this strategic problem, providing an area-wide contingency plan. The heuristics are evaluated on a set of 10 test problems that involve 1869 general integer variables and 3264 constraints. Computational tests indicate that four heuristics are quite effective, prescribing solutions for each of 10 test cases within 1.41% of optimum and within a few minutes runtime. This study focused on modeling the Galveston Bay Area, and the test problems represent application in that area. A sensitivity analysis is demonstrated by assessing the impacts of component availability and the degradation of cleanup capability over time. Use of the model as a decision support aid by responsible parties, contractors, governmental organizations and others is described.
    Type of Medium: Electronic Resource
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  • 12
    ISSN: 1460-9592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The efficacy, safety and resource implications of a single intravenous dose of ondansetron (0.1 mg·kg−1, maximum 4 mg) were assessed in a multinational, multicentre, randomized, double-blind, placebo-controlled trial of 427 children aged 1–12 years, undergoing tonsillectomy with/without adenoidectomy. Emesis (retching and/or vomiting) and nausea were analysed separately. Significantly more ondansetron-treated children had no episodes of emesis (127/212 (60%) vs 100/215 (47%); P=0.004) and experienced no postoperative nausea (135/211 (64%) vs 108/213 (51%); P=0.004) in the first 24 h. Ondansetron also reduced the number of emetic episodes (P〈0.001), the time to the first emetic episode (P〈0.001) and overall nausea severity (P=0.003). Significantly fewer ondansetron-treated children were rescued or withdrawn from the study (5%vs 10%; P=0.042). Fewer ondansetron-treated patients required nursing intervention (34%vs 45%; P=0.007) and the average intervention time was significantly shorter (4.6 vs 8.1 minutes; P=0.001). Resources used to manage PONV were significantly reduced by ondansetron (43%vs 57%; P=0.014).
    Type of Medium: Electronic Resource
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  • 13
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 804 (1996), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 14
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 804 (1996), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 15
    ISSN: 1432-0711
    Keywords: Key words IVF ; Sedation ; General anaesthesia ; Remifentanil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Anaesthetic management for oocyte retrieval may interfere with the results and success rate of an in vitro fertilization (IVF) program. This study was conducted to compare the effects of two different anaesthetic techniques (general anaesthesia versus sedation) used for oocyte retrieval on IVF outcome. For general anaesthesia we used a combination of remifentanil (UltivaTM) with either propofol or isoflurane in hypnotic concentrations. For sedation the protocol included midazolam, diazepam or propofol according to clinical needs. In total, 202 women were enrolled in the study. 96 women opted for sedation and 106 for general anaesthesia. The number of collected oocytes was significantly higher with general anaesthesia (10.54±5.43 [mean±SD]) than with sedation (6.25±3.65, p〈0.0001), whereas the number of fertilized oocytes was not different (4.70±3.57 vs. 4.23±2.90). There were no significant differences in cleavage and pregnancy rates. We therefore believe that remifentanil-based general anaesthesia without nitrous oxide is a suitable alternative to sedation and may be recommended for IVF oocyte retrieval if general anaesthesia is requested.
    Type of Medium: Electronic Resource
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