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  • 11
    Electronic Resource
    Electronic Resource
    Crack formation in epitaxial [110] thin films of YBa2Cu3O7−δ and PrBa2Cu3O7−x on [110]SrTiO3 substrates (1991)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 58 (1991), S. 1682-1684 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A characteristic feature of epitaxial [110] thin films of YBa2Cu3O7−δ and PrBa2Cu3O7−x on [110]SrTiO3 substrates is that the films have a tendency to crack along the (001) planes. We have studied the crack spacing as a function of deposition temperature and film thickness. The experimental data have been found to be in excellent agreement with a theoretical analysis of the crack spacings in brittle films. The study has allowed us to determine the critical thickness below which no cracks are expected to form as a function of temperature for [110] films of YBa2Cu3O7−δ, PrBa2Cu3O7−x, and YBa2Cu3O7−δ/ PrBa2Cu3O7−x bilayers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.105110
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  • 12
    Electronic Resource
    Electronic Resource
    Anomalous superperiodicity in scanning tunneling microscope images of graphite (1990)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 56 (1990), S. 2396-2398 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: An anomalously large periodicity has been observed in scanning tunneling microscope images of a (00.1) graphite sample. The unusual contrast has hexagonal symmetry, a periodicity of 7.7±0.2 nm and is superimposed on the usual a=0.246 nm atomic spacing of graphite. Current-voltage curves recorded in the scanning tunneling spectroscopy mode from the region showing the superperiodicity exhibit slightly more metallic behavior than those from neighboring normal regions. One possible explanation for the observed periodicity is that it is a rotational moiré pattern resulting from the overlap between a misoriented layer of graphite and the underlying graphite single crystal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.102906
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  • 13
    Electronic Resource
    Electronic Resource
    The immunoperoxidase localization of tumour markers in ovarian cancer: the value of CEA, EMA, cytokeratin and DD9 (1991)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 98 (1991), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Primary tumours from 40 patients with epithelial ovarian cancer, treated at St Thomas's Hospital over a 10-year period, were studied for the immunocytochemical expression of the following tumour markers in formalin-fixed paraffin embedded material: carcinoembryonic antigen (CEA), epithelial membrane antigen (EMA), cytokeratin (CAM 5.2), and DD9. An indirect immunoperoxidase staining technique was used. All of the tumours were positive for EMA and CAM 5.2, and 30% of them were positive for both CEA and DD9. The absence of CEA and DD9 may be of value in differentiating between metastatic abdominal adenocarcinomas of ovarian origin and those of gastrointestinal origin, but no indication of prognosis was obtained using these epithelial markers. The strong and widespread staining of all of the tumours for EMA suggests that this may be a useful marker for detecting metastatic or recurrent disease by immunoscintigraphy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1991.tb10315.x
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  • 14
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    W. D. Howarth, "Corneille: 'Le Cid'" (Book Review) (1991)
    Cambridge : Periodicals Archive Online (PAO)
    The Modern language review. 86:1 (1991:Jan.) 208 
    Details
    ISSN: 0026-7937
    Topics: Linguistics and Literary Studies
    Notes: REVIEWS
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:0094-1991-086-01-000084
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  • 15
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    P. Corneille, "Le Cid", ed. by Georges Forestier (Book Review) (1991)
    Cambridge : Periodicals Archive Online (PAO)
    The Modern language review. 86:1 (1991:Jan.) 208 
    Details
    ISSN: 0026-7937
    Topics: Linguistics and Literary Studies
    Notes: REVIEWS
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:0094-1991-086-01-000085
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  • 16
    Electronic Resource
    Electronic Resource
    The properties of cultured fetal human and rat brain tissue and its use as grafts for the relief of the Parkinsonian syndrome (1992)
    Springer
    Neurochemical research 17 (1992), S. 893-900 
    Details
    ISSN: 1573-6903
    Keywords: Human fetal brain cultures ; neural grafting ; dopamine ; Parkinson's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Primary cultures were derived from human fetal ventral mesencephalon and cerebral cortex at 7–11 weeks gestation, and from fetal rat mesencephalon and cortex at embryonic day 14–15. Immunohistochemical analysis of the mesencephalic cultures using antibodies to tyrosine hydroxylase (TH) showed between 0.1–0.5% of human cells to be TH positive and 0.1–1% of rat cells to be TH positive. HPLC analysis of extracts from the cultures showed that they had the ability to synthesise and store dopamine. Implantation of the cultured human and rat mesencephalic tissue into a 6-hydroxydopamine rat model of Parkinson's disease produced marked recovery from amphetamine induced rotational asymmetry in the recipient rats, but no such recovery was observed following implantation of cortical cultures. Histological examination demonstrated the presence of surviving human mesencephalic and cortical grafts at least 6 months after implantation. Implants of cultured fetal rat tissue were less obviously but still significantly effective in these experiments. These rat tissue grafts were detectable for periods of at least 6–8 weeks by histological staining.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00993265
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  • 17
    Electronic Resource
    Electronic Resource
    Chemical and isotopic composition of the lower crust beneath the Meguma Lithotectonic Zone, Nova Scotia: evidence from granulite facies xenoliths (1991)
    Springer
    Contributions to mineralogy and petrology 109 (1991), S. 69-88 
    Details
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Granulite-facies xenoliths from an Upper Devonian lamprophyre dyke near Tangier, Nova Scotia, provide new information about the lower crust in the Meguma Zone. Two mineralogically and chemically distinet groups of xenoliths occur. Both groups contain quartz+feldspar+biotite+Fe−Ti oxides+sulfides. In addition, group A contains garnet+graphite±[aluminosilicates+spinel±sapphirine (hight Al2O3 subgroups A1 and A2)] or [clinopyroxene+sphene+apatite (high CaO sub-group A3)]. Group B has highly variable proportions of orthopyroxene (B1), clinopyroxene (B2), and amphibole (B3). Trace-element contents of the highly aluminous xenoliths compare closely with average to upper crustal model compositions and are similar in many aspects to other “undepleted” granulite-facies rocks. LowP-T sedimentary assemblages of quartz-chlorite-clay minerals-calcite-albite or paragonite can account for the compositions of group A xenoliths. Within group B, a high-MgO (MgO〉13 wt%) subgroup with high transition-metal contents, and low-MgO (MgO〈9 wt%) sub-groups with higher LIL (large-ion-lithophile) element contents exist. Although the rare-earth and high-field-strength elements indicate a tholeiitic or low-K calc-alkaline chemistry, the LIL elements are as high as those from high-K calc-alkaline volcanic are rocks. Isotopically, group A ranges from εNdt=-2.56 to-0.80 and87Sr/86Sr t =0.7046 to 0.7182 fort=370 Ma. For group B these values are +1.45 to +5.33 and 0.7028 to 0.7048, respectively. Model ages (TCHUR) are correspondingly low and are tightly constrained (544±52 Ma). These “young” ages contrast with the middle Proterozoic Nd model ages of the overlying Meguma Zone low-grade flysch. This time-inverted stratigraphy appears to be the product of a tectonic break between a younger autochthonous Tangier lower crust (≡Avalon), and an older allochthonous Meguma Group upper crust.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687201
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  • 18
    Electronic Resource
    Electronic Resource
    5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum (1990)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 342 (1990), S. 9-16 
    Details
    ISSN: 1432-1912
    Keywords: 5-HT4 ; 5-HT3 ; Desensitization ; 5-Methoxytryptamine ; 2-Methyl-5-HT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Agonist-induced desensitization has been utilized to discriminate and independently “isolate” the neuronal excitatory receptors to 5-hydroxytryptamine (5-HT) in the guinea pig ileum (5-HT3 and putative 5-HT4 receptors). Electrically stimulated longitudinal muscle myenteric plexus preparations, and non-stimulated segments of whole ileum were used. Exposure to 5-methoxytryptamine (10 μmol/l) inhibited completely responses to 5-HT at the putative 5-HT4 receptor without affecting 5-HT3-mediated responses. Conversely, exposure to 2-methyl-5-HT (10 μmol/l) inhibited completely responses to 5-HT at the 5-HT3 receptor without affecting putative 5-HT4-mediated responses. The inhibition with 5-methoxytryptamine and 2-methyl-5-HT, either alone or in combination, appeared selective as responses to KCI, DMPP, carbachol, histamine, and substance P were unaffected or only very slightly modified. Furthermore, the pA2 values for ICS 205–930 at the putative 5-HT4 (pA2 = 6.2 to 6.5) and 5-HT3 (pA2 = 7.6 to 8.1) receptors (estimated in the presence of 2-methyl-5HT and 5-methoxytryptamine, respectively) were consistent with those estimated in the absence of desensitization. 5-Methoxytryptamine, but not 2-methyl-5-HT, suppressed completely but reversibly the concentration-effect curve to renzapride, suggesting that responses to this agent are mediated exclusively via agonism at the putative 5-HT4 receptor. It is concluded that 5-methoxytryptamine and 2-methyl-5-HT can be utilized as selective probes to discriminate the putative 5-HT4 receptor from the 5-HT3 receptor in guinea pig ileum. This finding is of importance as no selective antagonist exists for the putative 5-HT4 receptor. Furthermore, the presently described method of agonist-induced desensitization and 5-HT receptor discrimination may be useful for the identification and characterization of the putative 5-HT4 receptor in other tissues and species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00178965
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  • 19
    Electronic Resource
    Electronic Resource
    5-Hydroxytryptamine4 receptors mediate relaxation of the rat oesophageal tunica muscularis mucosae (1991)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 343 (1991), S. 439-446 
    Details
    ISSN: 1432-1912
    Keywords: 5-HT4 ; Oesophagus ; Rat ; ICS 205–930 ; Benzamides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The present study was designed to characterize an “atypical” 5-hydroxytryptamine (5-HT) receptor mediating relaxation of the rat oesophageal tunica muscularis mucosae. All experiments were performed under equilibrium conditions, using pargyline to inhibit the oxidative deamination of indoleamines, and cocaine and corticosterone to inhibit neuronal and extraneuronal uptake. Under these conditions 5-HT (0.3–1000 nmol/l) produced a concentration-dependent relaxation of carbachol-induced tension. The concentration-effect curve to 5-HT was unaffected by potent antagonists for 5-HT1, 5-HT2, 5-HT3 and so called 5-HT1P receptors (metergoline, methysergide, ketanserin, ondansetron, N-acetyl-5-hydroxytryptophyl-5-hydroxytryptophan amide), but was antagonized competitively by ICS 205–930 (pA2 = 6.7). Responses to 5-HT were mimicked by other indoleamines and substituted benzamides with the following order of potency: 5-HT ≥ 5-methoxytryptamine 〉 cisapride = α-methyl-5-HT = (S)-zacopride = renzapride 〉 (RS)-zacopride 〉 5-carboxamido-tryptamine = metoclopramide = (R)-zacopride 〉 tryptamine 〉 2-methyl-5-HT. ICS 205–930 afforded similar pA2 values (6.0–6.7) against each agonist, indicating a common site of action. Concentration-effect curves to 5-HT were not affected by tetrodotoxin or indomethacin, sugesting that 5-HT-induced relaxation of the tunica muscularis mucosae was mediated via a postjunctional receptor, independent of endogenous prostanoids. The pharmacological profile of the 5-HT receptor in the rat oesophageal tunica muscularis mucosae correlates well with the 5-HT4 receptor characterized recently in both the CNS and gastro-intestinal tract.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169544
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  • 20
    Electronic Resource
    Electronic Resource
    Preparation and fungitoxicity of 3,6-dichloro-and 3,6-dibromo-8-quinolinols (1994)
    Springer
    Monatshefte für Chemie 125 (1994), S. 723-730 
    Details
    ISSN: 1434-4475
    Keywords: 3,6-dichloro-8-nitroquinoline ; 3,6-dibromo-8-nitroquinoline ; 8-amino-3,6-dichloroquinoline ; 8-amino-3,6-dibromoquinoline ; 3,6-dichloro-8-quinolinol ; 3,6-dibromo-8-quinolinol ; 1H NMR spectra
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung 3,6-Dichlor- und 3,6-Dibrom-8-chinoline wurden durch direkte Halogenierung von 8-Nitrochinolin mit N-Halogensuccinimid in Essigsäure oder durch Halogenierung der entsprechenden nachSkraup synthetisierten 6-Halogen-8-nitrochinoline hergestellt. Die Nitrogruppe wurde zum Amin reduziert und die Aminofunktion in 70% iger Schwefelsäure bei 220°C zum Phenol hydrolysiert. Die Fungitoxizität der 3,6-Dichlor- und 3,6-Dibrom-8-chinoline und jene der bei ihrer Herstellung auftretenden Zwischenstufen gegenAspergillus niger, Aspergillus oryzae, Myrothecium verrucaria, Trichoderma viride undMucor cirinelloides wurde bestimmt. 3,6-Dichlor-8-chinolin ist der derzeit stärkste bekannte fungitoxische Vertreter dieser Substanzklasse.
    Notes: Summary 3,6-Dichloro- and 3,6-dibromo-8-quinolinols were prepared by direct halogenation of 8-nitroquinoline by N-halosuccinimide in acetic acid or by halogenation of the corresponding 6-halo-8-nitroquinoline prepared via aSkraup reaction. The nitro group was reduced to amino and the amine was hydrolyzed to the phenol in 70% sulfuric acid at 220°C. The fungitoxicity of 3,6-dichloro- and 3,6-dibromo-8-quinolinols, as well as intermediates in their preparation, againstAspergillus niger, Aspergillus oryzae, Myrothecium verrucaria, Trichoderma viride, andMucor cirinelloides was determined. 3,6-dichloro-8-quinolinol is the most fungitoxic analogue of this class of compounds observed to date.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01277632
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