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  • 11
    ISSN: 1432-2072
    Keywords: YM-14673 ; TRH ; Anti-reserpine action ; PGO wave
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Effects of YM-14673 (Nα-[{(S)-4-oxo-2-azetidinyl}-carbonyl]-l-histidyl-l-prolinamide dihydrate), a new TRH derivative, on reserpine-induced behavioural and electroencephalographic changes were observed in comparison with those of TRH. YM-14673 antagonized reserpine-induced hypothermia and decrease in convulsion threshold in mice. The number of PGO waves recorded from the lateral geniculate body was decreased by administration of YM-14673 in reserpinized cats. The anti-reserpine activity of intravenous YM-14673 was about 8–20 times more potent than that of TRH. In inhibiting reserpine-induced hypothermia, the oral ED2°C relative to IV ED2°C as an indirect indication of absorption rate of the drugs was 15 for both YM-14673 and TRH. These results suggest that YM-14673 possesses more potent facilitatory effects on the central monoamine systems than TRH.
    Type of Medium: Electronic Resource
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  • 12
    Electronic Resource
    Electronic Resource
    Springer
    Archives of virology 104 (1989), S. 169-174 
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Seven monoclonal antibodies with neutralizing activity to equine herpesvirus-1 were produced. These recognized either an 81kD or an 88kD viral glycoprotein. Some of the antibodies were shown to protect hamsters in a passive immunization experiment.
    Type of Medium: Electronic Resource
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  • 13
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 54 (1987), S. 51-55 
    ISSN: 1432-0584
    Keywords: Bromelin ; Antibody screening ; α2-Macroglobulin ; Thiol proteinase inhibitor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Human sera contain bromelin inhibitors in irregular antibody screening techniques. In order to identify and purify these inhibitors, pooled human sera were precipitated with ammonium sulfate, followed by DEAE-cellulose and Sephadex G-150 column chromatography. Proteinase activity and inhibitory activity to bromelin were observed in two protein fractions, these were identified as α2-macroglobulin and the S-2 thiol proteinase inhibitor.
    Type of Medium: Electronic Resource
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  • 14
    Electronic Resource
    Electronic Resource
    Springer
    Journal of radioanalytical and nuclear chemistry 90 (1985), S. 217-223 
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Mercury contents in head hair of 58 dentists employed at the NUSD hospital and 50 dentists employed at the private hospitals or clinics were determined using neutron activation analysis. The arithmetic means were 5.8 ppm and 5.2 ppm, and geometric means were 5.4 ppm and 4.8 ppm, respectively. They were much lower than the values reported in the past year, and agreed well with those of normal Japanese men of the same age. Therefore, it was concluded that the mercury pollution in the working environment of dentists might be practically non-existent in Japan today.
    Type of Medium: Electronic Resource
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