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  • 11
    Digitale Medien
    Digitale Medien
    Migration behaviour of petroleum-associated short-chain organic acids
    Amsterdam : Elsevier
    Organic Geochemistry 20 (1993), S. 1019-1025 
    Details
    ISSN: 0146-6380
    Schlagwort(e): core flooding ; hydrous pyrolysis ; migration ; short-chain organic acids ; water solubility
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Chemie und Pharmazie , Geologie und Paläontologie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1016/0146-6380(93)90110-W
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  • 12
    Digitale Medien
    Digitale Medien
    Ion-exchange high-performance liquid chromatographic analysis of the products of the enzymatic degradation of oxytocin
    Amsterdam : Elsevier
    Journal of Chromatography A 519 (1990), S. 244-249 
    Details
    ISSN: 0021-9673
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0021-9673(90)85153-M
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  • 13
    Digitale Medien
    Digitale Medien
    Primary gastric apoptosis-rich T-cell lymphoma co-expressing CD4, CD8, and cytotoxic molecules (2000)
    Springer
    Virchows Archiv 436 (2000), S. 357-364 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Key words Clinical course ; Immunohistochemistry ; Morphology ; Primary gastric T-cell lymphoma
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  In contrast to primary gastric lymphomas of B-cell type, little is known about primary gastric T-cell lymphomas. We describe three cases with remarkably similar features: diffuse growth, epitheliotropism, medium too large cell size, high apoptotic rates, and a CD3+, CD4+, CD8+, CD45RO+ immunophenotype. Clonal TCRγ gene rearrangement was shown in two cases. Epstein-Barr virus infection was excluded in two cases. Taking advantage of fresh-frozen material, we analyzed two cases further, revealing CD5–, CD16+, CD56–, CD57–, CD25+, CD30+, CD103 (αEβ7)+, bcl-2 protein+, CD95+, CD95 ligand(L)–. CD95L, however, was detected in histiocytic and fibroblastoid by stander cells. The lymphomas expressed granzyme B, perforin, and the TIA-1 antigen in various combinations. All three cases had a very unfavorable clinical course characterized by local recurrence and/or dissemination to other epithelial sites, leading to death within 6–12 months after the initial diagnosis despite surgery and aggressive antineoplastic treatment. These data suggest a novel variant of peripheral T-cell lymphoma operationally characterized as primary gastric, apoptosis-rich, CD103+, EBV-, T-cell lymphoma co-expressing CD4, CD8, CD16 and cytotoxic molecules.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004280050459
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  • 14
    Digitale Medien
    Digitale Medien
    PMA-activation of peripheral blood and tonsillar B lymphocytes induces large adhesive cells reminiscent of large extrafollicular (monocytoid) B cells (1994)
    Springer
    Virchows Archiv 424 (1994), S. 195-204 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Extrafollicular B lymphocytes ; Monocytoid B cell ; Phorbol 12-myristate 13-acetate ; CD11c ; CD62L (L-selectin)
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Extrafollicular (EF) B lymphocytes differ in size and morphology depending on the lymphatic organ involved and the kind of inflammatory reaction. On reevaluating EF B cells in various sites and conditions we discriminated three forms: a small (lymphoid) and intermediate (centrocytoid), and a large (monocytoid) variant. Immunohistochemically, these variants could be discriminated by their differential expression of adhesion molecules CD62L (L-selectin) and CD11c: small EF B cells were strongly L-selectin+ and CD11c−; intermediate cells were moderately CD62L+ and CD11c−; large cells were faintly CD62L+ or − but expressed CD11c. In 72 h cultures of normal peripheral and tonsillar B cells, cross-linking surface immunoglobulin in the presence of interleukin-2 or interleukin-4 led to formation of clusters in vitro together with an increase in cell size and a slight up-regulation of CD11c, as determined by flow cytometry. Stimulation with phorbol 12-myristate 13-acetate (PMA), however, gave rise to large, plastic adherent cells which also showed strong homotypic adhesion, expressed CD62L at minimal levels and CD11c at comparably highest levels and altogether mimicked the large cell variant of EF B cells. We conclude that EF B cells are subjected to cytokine-induced metamorphosis and that differences in cell size and morphology reflect their state of activation and activation-associated adhesion properties. Our data suggest that EF B cells in all anatomical sites are functionally closely related cells which — possibly mediated by CD11c/CD18 — may become sessile and proliferate locally once activated by appropriate signals.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00193500
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  • 15
    Digitale Medien
    Digitale Medien
    Differential expression of β1, β3 and β4 integrins in sarcomas of the small, round, blue cell category (1995)
    Springer
    Virchows Archiv 426 (1995), S. 19-25 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Small round blue cell sarcomas ; Integrins ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Integrins are a large and complex family of membrane spanning αβ heterodimeric cell surface glycoproteins mediating cell/cell and cell/matrix interactions. Small, round, blue cell sarcomas (SRBCS) are a group of poorly differentiated tumours of various and in part uncertain histogenesis displaying similar cytomorphology. Among them are rhabdomyosarcomas (RMS), ganglioneuroblastomas [(G)NB], primitive peripheral neuroectodermal tumours (pPNET) and Ewing's sarcomas (ES). Thirty-two SRBCS were studied immunohistochemically for the distribution of β1, β3 and β4 integrins in situ. We found complex and to some extent differential patterns of β1, β3 and β4 integrin subunit expression in different types of SRBCS: all of the sarcomas studied were consistently β1+, β4−, α2−. Four of nine RMS were completely negative for all other integrin subunits studied while one RMS was α5+ throughout and three RMS were focally α5+. Three RMS expressed the α6 and αv chains. In contrast to RMS, pPNET and ES, all of which were α1−, α3−, (G)NB were α3+ and frequently co-expressed α1. The eight pPNET and seven ES studied showed a similarily restricted integrin profile that was limited to the expression of β1 and α5 in nearly all cases. In summary, RMS were β1+, α1−, α3− and heterogeneously expressed α5 and α6. (G)NB were generally β1+, α1+, α3+, α5−, α6−. pPNET and ES were β1+, α1−, α3−, α5+, α6−. The data illustrate a complex expression pattern of various integrins in SRBCS, a differential expression pattern of some of the integrin subunits among different types of SRBCS and almost identical integrin profiles in pPNET and ES.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00194694
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  • 16
    Digitale Medien
    Digitale Medien
    In situ expression of β1, β3 and β4 integrin subunits in non-neoplastic endothelium and vascular tumours (1994)
    Springer
    Virchows Archiv 425 (1994), S. 375-384 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Endothelium ; Vascular tumours ; Integrins Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Endothelial cells play an important role in adhesive interactions between circulating cells and extracellular matrix proteins. In vitro studies have shown that many of these processes are mediated by a superfamily of αβ heterodimeric transmembrane glycoproteins called integrins. The distribution patterns of β1, β3 and β4 integrin subunits in endothelial cells (EC) in situ were examined immunohistochemically on serial forzen sections of a wide range of non-neoplastic tissues and of vascular tumours, both benign and malignant. Expression of the β1 subunit was a constitutive feature of EC. Among the β1-associated α subunits, α5 and α6 were broadly distributed in EC, irrespective of vessel size and microenvironment. The α3 subunit displayed intermediate levels of expression with a slight preference for small vessel EC. Presence of α1 was confined to EC of capillaries and venules/small veins. Expression of α2 in EC was inconsistent. With rare exceptions, the α4 chain was absent in EC. The β3 and αv subunits were expressed in most EC, though not always concomitantly. In contrast to the β1 chain, however, these integrin subunits were absent in EC of glomerular capillaries and were expressed variably in sinusoidal EC. The β4 chain was evenly present in the great majority of EC, except for those of large vessels. In vascular tumours, the patterns of β1 and α1 to α6 subunit expression generally corresponded to those found in their non-neoplastic counterparts. Expression of β3, αv and β4 chains, however, decreased in neoplasia, especially in angiosarcomas. These data show that EC dispose of broad and at the same time differential repertoires of integrin subunits that presumably reflect vessel-type associated functional differences among these cells. In vascular tumours, the orthologous distribution patterns of β1 and α1 to α6 chains are conserved in most instances while the amounts of β3, αv and β4 subunits expressed in EC tend to decrease in the course of malignant transformation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00189575
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  • 17
    Digitale Medien
    Digitale Medien
    Synoviocytes in chronic synovitis in situ and cytokine stimulated synovial cells in vitro neo-express α1, α3 and α5 chains of β1 integrins (1994)
    Springer
    Virchows Archiv 425 (1994), S. 171-180 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Interferon-γ ; Tumour necrosis factor-α ; Transforming growth factor-β ; Interleukin-1β ; Inflammation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The expression of the β1 integrins was examined immunohistochemically in synoviocytes from normal synovial membrane and from chronic synovitis of different aetiology and intensity. Normal synoviocytes were α6β1-positive but lacked α1 through α5. In mild inflammation type A synoviocytes neo-expressed α1, α3, and α5 chains. In severe inflammation both type A and B synoviocytes expressed α3, α4, α5, and α6 chains. The effects of inflammatory cytokines, as single agents or in combination, on the β1 integrin expression in cultured normal synoviocytes was determined by immunocytochemistry and flow cytometry. The α1 chain, while absent in unstimulated synoviocytes, was induced by interleukin-1β (IL-1β), tumour necrosis factor-α (TNF-α), and interferon-γ (INF-γ). This effect was enhanced by combining IL-1β and TNF-α. Expression of the α3 chain was up-regulated by IL-1β and, more intensely, by IFN-γ. Transforming growth factor β (TGF-β) inhibited the up-regulating effect of IL-1β and antagonized the effect of IFN-γ on α3 chain expression. Expression of the α5 chain was up-regulated significantly by co-stimulation through IL-1β together with TGF-β or TNF-α. Thus, the β1 integrin profile of cytokine activated synoviocytes in vitro resembled that of synoviocytes in synovitis in situ. These data suggest that IL-1β, TNF-α, IFN-γ, and TGF-β are likely to be among the effectors regulating β1 integrin expression in synoviocytes in vivo.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00230354
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  • 18
    Digitale Medien
    Digitale Medien
    Application of capillary and free-flow zone electrophoresis and isotachophoresis to the analysis and preparation of the synthetic tetrapeptide fragment of growth hormone-releasing peptide
    Amsterdam : Elsevier
    Journal of Chromatography B: Biomedical Sciences and Applications 656 (1994), S. 99-106 
    Details
    ISSN: 0378-4347
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0378-4347(94)00042-5
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  • 19
    Digitale Medien
    Digitale Medien
    Effect of human serum oxytocinase on the antidiuretic action of lysine vasopressin and oxytocin in the rat (1967)
    Springer
    Cellular and molecular life sciences 23 (1967), S. 196-197 
    Details
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Zusammenfassung Nach i.v. Dauerinfusion von Lysin-Vasopressin oder Oxytocin wird bei der experimentellen Analyse der Wirkung menschlicher Oxytocinase eine Erniedrigung des antidiuretischen Effekts gefunden; diese rührt vom Absinken der Peptidkonzentration sowohl im Blutplasma als auch am Wirkort her.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02136282
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  • 20
    Digitale Medien
    Digitale Medien
    Seltene Manifestation einer Großgefäßvaskulitis bei systemischem Lupus erythematodes (2000)
    Springer
    Zeitschrift für Rheumatologie 59 (2000), S. 330-333 
    Details
    ISSN: 0340-1855
    Schlagwort(e): Schlüsselwörter Lupus erythematodes –¶Großgefäßvaskulitis – Histologie ; Key words Lupus erythematosus – large-vessel vasculitis – histology
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Summary Case-reports from two female patients with an occlusion of the right external iliac artery and femoral artery are presented due to a large-vessel vasculitis. Both patients suffered from systemic lupus erythematosus This rare manifestation occured within the first few years of the disease and was important for prognosis and further treatment. Other manifestations of the disease were general symptoms and polyarthritis. In one case the vascultitis was confirmed by histology.¶   A fibrous thickening of the intima and a vasculitis of small vessels within the adventitia were the prominent feature. This observation supports the idea of small vessel vasculitis as the characteristic manifestation in lupus erythematosus.
    Notizen: Zusammenfassung Zwei Fallberichte dokumentieren den Verschluss der Arteria iliaca externa bzw. der Arteria femoralis superficialis rechts bei Patientinnen mit einem systemischen Lupus erythematodes im Rahmen einer Großgefäßvaskulitis. Diese sehr selten beschriebene Manifestation trat innerhalb der ersten Jahre der Autoimmunerkrankung auf und war für Prognose und Therapie bestimmend. Ansonsten waren bei beiden Patienten Allgemeinsymptome und eine Gelenkbeteiligung als weitere Manifestation der Grunderkrankung anzusehen. In einem Fall konnte eine histologische Sicherung der Vaskulitis erfolgen. Dabei war eine fibrinöse Verdickung der Intima und eine Vaskulitis der kleinen Arterien in der Adventitia auffällig. Diese Beobachtung unterstützt die Annahme, dass die sekundäre Vaskulitis im Rahmen eines Lupus erythematodes eigentlich als Kleingefäßvaskulitis aufzufassen ist.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s003930070055
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