Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 11
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 66 (1985), S. 134-139 
    ISSN: 1432-0533
    Keywords: Indirect immunofluorescence ; Endothelial cells ; Multiple Sclerosis ; Polymyositis ; Myasthenia gravis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The blood-brain barrier (BBB) is disrupted in many of the lesions of multiple sclerosis (MS). Immunologically mediated injury to one of the major components of this barrier, the cerebral capillary, may play a role in the development of the lesion. We therefore examined the sera of 51 cases of MS for the presence of autoantibodies to endothelial and smooth muscle cells, using the indirect immunofluorescent technique. The results were compared to those in other groups of patients with neuroimmunological disorders. We found no anti-endothelial cell antibodies, but autoantibodies to vascular smooth muscle were detectable in 31% of the MS sera tested. They were also present, however, in 30% of sera from cases of myasthenia gravis and in the serum of one of 12 cases of polymyositis. It is considered to be unlikely that antibodies to vascular tissues play any pathogenetic role in multiple sclerosis.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 12
    ISSN: 1432-0533
    Keywords: Forssman carotid syndrome ; Experimental allergic encephalomyelitis (EAE) ; Vasculopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The Forssman carotid syndrome was induced in guinea pigs to study the mechanism of demyelination-like lesions in this animal model and to compare it with experimental allergic encephalomyelitis (EAE). Acute lesions were studied at 1–3 days after intracarotid injection of rabbit anti-Forssman antibody and chronic lesions at 7–21 days post injection, using routine histological, immunofluorescent, and electron-microscopic techniques. The results were compared to those in a group of guinea pigs with acute or chronic lesions of EAE. The picture was remarkably similar in the two conditions, in regard to localization in the central nervous system (CNS), composition of cellular infiltrates, diameter of lesions produced, myelin loss and axonal degeneration, together with gamma globulin deposition in small vessels in affected areas. The differences were that in the Forssman carotid syndrome, in contrast to EAE, there were no mononuclear cell infiltrates in the acute phase, and no evidence of macrophages invading myelin sheaths was detected. Perivascular lesions consisted of demyelination within infiltrates of mononuclear cell in chronic relapsing EAE, but not in the Forssman carotid syndrome. It is suggested that investigation of the distinction between the two models of the CNS may be of benefit in the pathogenetic study of demyelinating disease.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 13
    ISSN: 1432-0533
    Keywords: Multiple sclerosis ; Cerebral endothelial cells ; Experimental allergie encephalomyelitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Multiple sclerosis is considered to be an autoimmune demyelinating disease of the central nervous system. Damage to the blood-brain barrier, of which endothelial cells are the main constitutent, occurs in multiple sclerosis, probably due to immunological mechanisms. We report here the results of immune-mediated damage to these cells, produced by immunizing guinea pigs with an endothelial cell membrane fraction. The fraction was obtained from cerebral endothelial cells grown in vitro and was free from myelin basic protein. The immunized animals developed a chronic neurological illness with evidence of delayed hypersensitivity to the cell membrane fraction but not to myelin antigens. Histological examination of the brain in the acute stage showed mononuclear cell infiltrates aroud blood vessels, while in the chronic phase large areas of demyelination, especially in the periventricular region, were present. This bore a striking similarity to the brain in multiple sclerosis. This may prove to be a useful new animal model for the investigation of the human demyelinating disease.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 14
    Electronic Resource
    Electronic Resource
    Springer
    Neurological sciences 5 (1984), S. 23-31 
    ISSN: 1590-3478
    Keywords: Polymyositis ; dermatomyositis ; immunology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Della polimiosite, (PM) malattia infiammatoria dei muscoli, vengono tratteggiati gli aspetti clinici più tipici, i criteri diagnostici e le linee terapeutiche. Frequente è la compromissione di altri organi come la cute da cui la definizione di dermatomiosite. Le alterazioni cardiache si caratterizzano per un peculiare disturbo di conduzione atrio-ventricolare, correlato ad un autoanticorpo specifico anti-Ro presente nel 25% dei pazienti. L'eziologia della PM non è ancora nota anche se vi sono una serie di evidenze in favore di una patogenesi autoimmune. Frequente è l'associazione con altre malattie immunomediate quali la miastenia grave, il pemfigo, la vasculite da immunocomplessi e la sindrome di Sjogren. Le indagini di laboratorio rivelano una ipergammablobulinemia, una diminuzione dei fattori del complemento C3 e C4 e la presenza di immunocomplessi circolanti nel 70% dei pazienti. Molto frequente, specie nei casi di dermatomiosite è l'accumulo istologicamente rilevabile di IgG e complemento nelle pareti dei vasi venosi intramuscola-ri. L'ipersensibilità cell-mediated enfatizzata in passato come molto significativa nella PM non è stata confermata. È stata esclusa da una serie di indagini di laboratorio la presenza di linfocitossicità specifica antifibra muscolare che era considerata l'Hallmark patogenetico della degenerazione muscolare nella P.M. In una serie di pazienti con diverse forme cliniche di PM gli Autori hanno riscontrato una severa diminuzione nel numero di linfociti soppressori/citotossici nel sangue periferico e un relativo aumento del primo subset. Questi risultati supportano l'ipotesi che un severo disturbo del controllo immunitario è presente nella PM ed è causa di una moltitudine di anomalie immunologiche la cui caratterizzazione è ancora oggetto di studio.
    Notes: Abstract The most typical clinical features of polymyositis (PM), the criteria of diagnosis and principles of treatment are outlined. An inflammatory disease of muscle, PM also frequently affects other organs such as the skin and hence the name dermatomyositis. The principal cardiac symptom is a peculiar disturbance of atrioventricular conduction, correlated with a specific anti-Ro autoantibody, present in 25% of patients. The etiology of PM is as yet unknown, although there is evidence for an autoimmune pathogenesis. It is frequently found in association with other immune-mediated diseases such as myasthenia gravis, pemphigus, immune-complex vasculitis and Sjogren syndrome. Laboratory investigations show hypergammaglobulinemia, a decrease of complement factors C3 and C4 and the presence of circulating immune complexes in 70% of patients. Very frequent, especially in cases of dermatomyositis, is a histologically detectable accumulation of IgG and complement in the walls of the intramuscular venous vessels. Cell-mediated hypersensitivity, emphasised formerly as highly significant in PM, has not been confirmed. The presence of specific antimyoglobin lymphocyto-toxicity, once considered to be the hallmark of muscle degeneration in PM, has been excluded by a number of laboratories. In a personal series of patients with various clinical forms of PM a severe loss of suppressor/cytotoxic lymphocytes was found in the peripheral blood and a relative increase in the first subset. These results support the hypothesis that a serious disturbance of immunoregulation is present in PM and is the cause of a multitude of immunological anomalies, the characterisation of which is under study.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...