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  • 11
    Electronic Resource
    Electronic Resource
    Identification of IgE and IgG binding epitopes on β- and κ-casein in cow's milk allergic patients (2001)
    Oxford, UK : Blackwell Science, Ltd
    Clinical & experimental allergy 31 (2001), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Cow's milk allergy (CMA) affects 2.5% of children aged less than 2 years of age. Although β- and κ-casein are considered among the major allergens responsible for CMA, no data are available on their allergenic epitopes in humans.Objective The aim of the study was to identify IgE- and IgG-binding epitopes on β- and κ-casein and to determine whether the pattern of epitope recognition is associated with the natural history of CMA.Methods Overlapping decapeptides representing the entire length of β- and κ-casein, respectively, were synthesized on a cellulose-derivatized membrane. Sera from 15 milk-allergic children, 4–18 years of age, with high levels of specific IgE antibodies to cow's milk were used to identify IgE- and IgG-binding epitopes. In addition, IgE epitopes were screened with pooled or individual sera from younger patients aged less than 3 years and who had low levels of specific serum IgE, who are likely to outgrow CMA.Results Six major and three minor IgE-binding epitopes, as well as eight major and one minor IgG binding regions, were identified on β-casein. Eight major IgE-binding epitopes, as well as two major and two minor IgG-binding epitopes, were detected on κ-casein. Three of the IgE binding regions on β-casein and six on κ-casein were recognized by the majority of patients in the older age group, but not by the younger patients.Conclusion Information regarding the immunodominant epitopes in β- and κ-casein may be important for understanding the pathophysiology and natural history of CMA. Differences in epitope recognition may be useful in identifying children who will have persistent milk hypersensitivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2222.2001.01167.x
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  • 12
    Electronic Resource
    Electronic Resource
    Ontogenetic induced shifts in the ecology of sunbleak Leucaspius delineatus during early development (2005)
    Oxford, UK; Malden, USA : Blackwell Science Ltd
    Journal of fish biology 67 (2005), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Using the non-native sunbleak Leucaspius delineatus as a model, the relationship between ontogeny and ecology was studied with a view to identifying specific morphological and physiological processes involved in influencing ecological niche shifts. Following a predefined saltatory model for the early ontogeny of sunbleak, field studies examined the temporal use of microhabitat, diet and morphological changes throughout early development. Following a dramatic shift in both morphology and ecology between the free embryo phase and the larval period, habitat use and diet showed little change during the larval period, with habitat use confined to marginal, vegetated areas and prey items associated with these habitats well represented in the diet. During the final larval step (L5), transition to the juvenile period resulted in the stabilization of relative growth, acquisition of the adult morphotype and was associated with a clear shift in diet and habitat use. During this period, sunbleak moved for the first time into open, deeper water, away from the banks, and utilized a similar range of food items to the adults. Specific relationships between form and function are further discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0022-1112.2005.00917.x
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  • 13
    Electronic Resource
    Electronic Resource
    A potential role for invasive sunbleak in the further dissemination of a non-native parasite (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Journal of fish biology 67 (2005), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Since its first introduction to English waters in the mid 1980s, sunbleak Leucaspius delineatus has spread widely and it is shown in the present study that this non-native cyprinid is a new host for Neoergasilus japonicus. This copepod parasite from South East Asia has a limited host range and distribution in the U.K. Rapid dispersal of sunbleak in the U.K. raises concerns for further dispersal of this introduced parasite.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.2005.00859.x
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  • 14
    Electronic Resource
    Electronic Resource
    Escapees of potentially invasive fishes from an ornamental aquaculture facility: the case of topmouth gudgeon Pseudorasbora parva (2004)
    Oxford, UK; Malden, USA : Blackwell Science Ltd
    Journal of fish biology 65 (2004), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Accidental escapees from aquacultural facilities are an ongoing problem facing scientists, conservationists, policy makers and naturalists throughout the world. The topmouth gudgeon Pseudorasbora parva, a small cyprinid native to Southeast Asia, was introduced to Romanian waters in 1960 via the aquaculture trade and has since spread throughout Europe. It first appeared in England in an ornamental fish farm near Romsey in Hampshire. The aim of the present study was to quantify the dispersal of this potentially highly invasive species from an ornamental fish farm into the wild. In order to measure the dispersal of escapees, intensive electrofishing surveys were carried out between June and September 2003 in the catchment downstream of the fish farm. The distribution of topmouth gudgeon in the catchment was found to be limited and patchy. The presence of small individuals suggests that the species has successfully established itself in the wild, but this remains to be confirmed. The results were examined in light of invasion theory principles of biological resistance and ecological fitness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0022-1112.2004.00559ac.x
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  • 15
    Electronic Resource
    Electronic Resource
    Utility of the ratio of food-specific IgE/total IgE in predicting symptomatic food allergy in children (2005)
    Oxford, UK : Munksgaard International Publishers
    Allergy 60 (2005), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Double-blind, placebo-controlled food challenges are time-consuming, expensive and not without risk to patients. Therefore, an in vitro test that could accurately diagnose food allergy would be of great value.Objective:  To evaluate the utility of the ratio of specific immunoglobulin E (IgE)/total IgE compared with specific IgE (sIgE) alone in predicting symptomatic food allergy.Methods:  We retrospectively analysed 992 controlled oral food challenges performed in 501 children (median age 13 months). The ratio of sIgE/total IgE was calculated and tested for correlation with the outcome of food challenges. Receiver operator characteristics (ROC)-curves were performed; predicted probabilities and predictive decision points were calculated.Results:  A significant correlation was found between the ratio and the outcome of food challenges for cow's milk (CM), hen's egg (HE), and wheat, but not for soy. The ROC and predicted probability curves as well as sensitivity and specificity of the decision points of the ratio were similar to those of sIgE levels for CM, HE and wheat.Conclusion:  In view of the greater effort needed to determine the ratio, without benefit compared with the sIgE alone, the calculation of the ratio of sIgE/total IgE for diagnosing symptomatic food allergy offers no advantage for CM, HE, wheat or soy. For the majority of cases controlled oral food challenges still remain the method of choice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.2005.00806.x
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  • 16
    Electronic Resource
    Electronic Resource
    Humoral and cellular responses to cow milk proteins in patients with milk-induced IgE-mediated and non-IgE-mediated disorders (2005)
    Oxford, UK : Munksgaard International Publishers
    Allergy 60 (2005), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Cow milk allergy (CMA) is one of the most common food allergies in childhood. Patients with CMA present with a wide range of immunoglobulin (Ig)E- and non-IgE-mediated clinical syndromes. Limited information is known about the specific humoral and cellular responses to cow milk proteins in these various forms of CMA.Objective:  The aim of the study was to determine IgE, IgA, IgG1 and IgG4 antibody levels and lymphocyte proliferative responses to the major cow milk allergens in patients with IgE- and non-IgE-mediated CMA.Methods:  One hundred and forty cow milk allergic patients, 6 months to 22 years of age, were included in the study. One hundred and thirteen patients had IgE-mediated CMA, 11 had milk protein-induced enterocolitis syndrome and 16 had allergic eosinophilic gastroenteritis. Twenty-one patients without food allergy, 8 months to 18 years of age, served as controls. Serum IgE, IgA, IgG1 and IgG4 antibodies to α-, β-, and κ-casein, α-lactalbumin and β-lactoglobulin were measured using enzyme-linked immunosorbent assays. For a subset of these patients, we performed lymphocyte proliferation assays to the various milk allergens.Results:  Patients with IgE-mediated CMA had higher specific IgE concentrations to casein compared with whey proteins (P 〈 0.001). In this group of patients, there was a positive correlation between IgE levels and levels of the other isotypes for all four milk proteins (P 〈 0.001). In general, the caseins were the more allergenic and antigenic proteins in all groups of patients. Patients with enterocolitis syndrome produced less milk protein-specific IgG4 (P 〈 0.05) and had a trend for higher IgA antibody levels when compared to the control group. Lymphocyte proliferative responses in all groups with CMA were significantly higher than controls (P 〈 0.05), although this response was similar in patients with IgE- and non-IgE-mediated CMA.Conclusion:  There is a distinct pattern of humoral antibody response in the different forms of CMA. Patients with IgE-mediated CMA have an elevated polyisotypic response to cow milk protein. The relative lack of specific IgG4 production in patients with enterocolitis syndrome may be involved in the pathogenesis of the disease. In general, caseins appear to be the predominant allergen in patients with CMA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.2005.00705.x
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  • 17
    Electronic Resource
    Electronic Resource
    Controlled oral food challenges in children – when indicated, when superfluous? (2005)
    Oxford, UK : Munksgaard International Publishers
    Allergy 60 (2005), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The diagnostic work-up of suspected food allergy includes the skin prick test (SPT), the measurement of food specific immunoglobulin E (IgE) antibodies using serologic assays, and more recently the atopy patch test (APT). For specific serum IgE and the SPT, decision points have been established for some foods allowing prediction of clinical relevance in selected cases. The APT may be helpful, especially when considered in combination with defined levels of specific IgE. Controlled oral food challenges still remain the gold standard in the diagnostic work-up of children with suspected food allergy. Most food allergic children will lose their allergy over time. As there is no laboratory parameter, which can accurately predict when clinical tolerance has been developed, controlled oral food challenges are the measure of choice. In this article, the current knowledge of predictors for the outcome of oral food challenges is reviewed and proposals for the daily practical work-up in the case of suspected food related clinical symptoms are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.2005.00828.x
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  • 18
    Electronic Resource
    Electronic Resource
    Specific oral tolerance induction with food in children: transient or persistent effect on food allergy? (2005)
    Oxford, UK : Munksgaard International Publishers
    Allergy 60 (2005), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  The standard treatment of food allergy is elimination of the incriminated food from the diet. Specific oral tolerance induction (SOTI) seems to be a promising approach for a causal treatment; however, it is unclear whether the tolerance achieved is transient or persistent. We report on a subset of three patients of a larger ongoing study who were treated successfully with SOTI treatment, but experienced a secondary loss of tolerance after a period of allergen avoidance.Methods:  The patients suffered from IgE-mediated allergy either to cow's milk (CM) (patient A) or hen's egg (HE) (patients B and C), confirmed by double-blind, placebo-controlled food challenge (DBPCFC). SOTI treatment was performed at home on a daily basis until tolerance to a maximum of 250 ml CM or 4.5 g lyophilized HE protein was achieved. The daily maintenance dose was 100 ml CM or 2.5 g HE protein.Results:  Patients A, B and C reached tolerance to the maximum dose after 37, 41 and 52 weeks, respectively. According to the protocol, patients A and B performed a strict secondary elimination diet for 2 months prior to a follow-up DBPCFC after a maintenance phase of 27 and 39 weeks, respectively. Patient C discontinued treatment for 2 days after 4 weeks on the maintenance dose. Despite previous tolerance, on re-exposure to the allergen all patients experienced moderate systemic allergic reactions.Conclusions:  We conclude that SOTI can induce transient tolerance in food allergy, but does not necessarily lead to its permanent abrogation. Regular allergen intake seems necessary to maintain the established tolerance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.2005.00882.x
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  • 19
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    Unknown
    Martin, R. A.: Syntactical Evidence of Semitie Sources in Greek Documents (Book Review) (1979)
    Berlin : Periodicals Archive Online (PAO)
    Orientalistische Literaturzeitung. 74:2 (1979:März/Apr.) 144 
    Details
    ISSN: 0030-5383
    Topics: Linguistics and Literary Studies , Ethnic Sciences , History
    Notes: Besprechungen
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:4148-1979-074-02-000029
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  • 20
    Electronic Resource
    Electronic Resource
    A ^3^1P- and ^2H-NMR study on the structural perturbations induced by charged detergents in the headgroup region of phosphatidylcholine bilayers
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 855 (1986), S. 365-374 
    Details
    ISSN: 0005-2736
    Keywords: Alkyltrimethylammonium bromide ; Headgroup structure ; Membrane-detergent interaction ; NMR ; Phosphatidylcholine ; Phospholipid bilayer
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2736(86)90082-9
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