ISSN:
0268-2605
Schlagwort(e):
dimethylarsinic acid
;
chronic exposure
;
demethylation
;
arsenite
;
rat
;
urine
;
feces
;
methylation
;
inductively coupled plasma mass spectrometry (ICP-MS)
;
ion chromatography (IC)
;
Chemistry
;
Industrial Chemistry and Chemical Engineering
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
Metabolites of dimethylarsinic acid (DMA) were studied in rats chronically exposed to DMA in drinking water. The urine was collected by forced urination at the end of 8, 20 and 30 weeks and the feces at the end of 30 weeks. The samples were analyzed for arsenic species by a combined system of ion chromatography and inductively coupled plasma mass spectrometry (IC-ICP-MS). Increases in arsenite, DMA, trimethylarsine oxide and a still-to-be-identified arsenic compound (which was eluted immediately after monomethylarsonic acid on the chromatogram) were detected in both urine and feces. At the 100 mg l-1 dose, DMA was the main component in the urine; arsenite was a main component in the feces. The results indicate that, besides undergoing methylation, DMA can be demethylated to inorganic arsenic, and demethylation of DMA may be associated with intestinal bacteria
Zusätzliches Material:
3 Ill.
Materialart:
Digitale Medien
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