ISSN:
1432-2013
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary 1. In human subjects metabolic alcalosis was induced by 0,5 g/kg NaHCO3. Gas mixtures of about 0, 2, 4, and 6% CO2, 35% O2 in N2 were inhaled, and the response of respiratory minute volume to variation of alveolar (arterial)pco 2 was determined. Alveolarpco 2 was read as endtidalpco 2 from an infrared analyzer record. During inhalation of each gas mixture samples of arterial blood were taken from an indwelling needle in the femoral artery. CO2 content, O2 content, O2 capacity andph were determined with routine methods.pco 2 and whole blood buffer base were calculated. 2. In alcalosis the curve describing the dependance of respiratory minute volume upon alveolarpco 2 was shifted to higherpco 2 in comparison to the control experiments in an approximately parallel way. The shift perph unit, however, was smaller than was found in earlier experiments on acidosis with similar methods. This indicates that the partialph sensitivity of respiration is diminishing in the alcaline range. 3. The data were used together with already published data on metabolic acidosis to draw isoventilatory lines in apco 2-ph diagramm which allows to isolate the partialpco 2 andph effects and gives a more general information on the dependance of lung ventilation upon the parameters of acid base equilibrium.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00362379
Permalink
