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  • 11
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 233-236 (Jan. 2003), p. 365-370 
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 12
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 233-236 (Jan. 2003), p. 119-126 
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 13
    ISSN: 1432-2307
    Keywords: Key words p53 Mutation ; Overexpression ; Dysplastic nodule ; Hepatocellular carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  In hepatocarcinogenesis, both de novo and multistep pathways have been suggested and in the latter a dysplastic nodule is the proposed precancerous lesion. In this study, we tried to ascertain whether or not the p53 gene is altered in low-grade/high-grade dysplastic nodules (LDN/HDN) and to determine the role of p53 alteration in multistep hepatocarcinogenesis. Eight hepatocellular carcinomas (HCCs), 9 HDNs, 17 LDNs and 25 cirrhotic nodules (LCs) were examined by polymerase chain reaction-single strand conformation polymorphism/direct sequencing and immunohistochemical staining for p53. Four of the 8 HCCs (50%) revealed p53 overexpression and 2 (25%) had missense mutations. Four of the 9 HDNs (44%) showed weak and/or focal p53 overexpression but none had mutation in the exons examined. Neither p53 overexpression nor mutation was found in 17 LDNs and 25 LCs. These results suggest that p53 mutation might be an unusual event in precancerous lesions of multistep hepatocarcinogenesis (DN-HCC sequence) and may play a less crucial part than in colorectal carcinogenesis.
    Type of Medium: Electronic Resource
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  • 14
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 432 (1998), S. 85-87 
    ISSN: 1432-2307
    Keywords: Key words Hepatoid adenocarcinoma ; AFP-producing gastric carcinoma ; Stomach ; Alpha-fetoprotein ; Metastasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Hepatoid adenocarcinoma (HA) is a rare variant of adenocarcinoma of the stomach, which is clinically characterized by increased level of serum α-fetoprotein(AFP) and poor prognosis. Microscopic findings include both adenocarcinomatous and hepatoid elements. A case of gastric adenocarcinoma with focal hepatoid differentiation confined within the metastatic lymph nodes occurred in a 55-year-old woman, who developed an advanced gastric carcinoma composed entirely of a typical papillo-tubular adenocarcinoma. Metastatic tumors were present in 8 of 13 perigastric lymph nodes, and 3 of these showed medullary and trabecular tumour growth reminiscent of hepatocellular carcinoma with immunohistochemical positivity for AFP. Preoperative serum AFP was 630 ng/ml and dropped to 76 ng/ml 2 weeks after the operation. Microscopic and immunohistochemical studies on the entire primary tumour tissue failed to demonstrate a focus of hepatoid or an AFP-positive area. This suggests that elevation of serum AFP may be reflected by focal hepatoid differentiation only in the metastatic lymph nodes, requiring extensive evaluation of the metastatic tumour in regional lymph nodes in the case of AFP-producing gastric carcinoma.
    Type of Medium: Electronic Resource
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  • 15
    Electronic Resource
    Electronic Resource
    Springer
    Journal of materials science 19 (2000), S. 1759-1761 
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 16
    Electronic Resource
    Electronic Resource
    Springer
    Journal of materials science 18 (1999), S. 1175-1176 
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 17
    Electronic Resource
    Electronic Resource
    Springer
    Medical & biological engineering & computing 22 (1984), S. 564-568 
    ISSN: 1741-0444
    Keywords: Action potential ; Computer simulations ; Electrical characteristics ; Low pass filters ; Radial decline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract A modified line source model presented earlier has been used to study the decline of the extracellular single muscle fibre action potential. The muscle tissue is modelled as a low-pass filter. The transfer function of the filter declines more slowly than a first order low-pass filter at low frequencies, but much faster at high frequencies. The cutoff frequency of the filter increases when the anisotropy of the muscle decreases. It also increases proportionally with the propagation velocity of the action potential. The decline of different frequency components obtained from the modified line source volume conductor and a filter model derived from experimental measurements are compared and their differences explained. The modified line source model was found to be identical to the volume conductor model in terms of results and at the same time conceptually simple for applications.
    Type of Medium: Electronic Resource
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  • 18
    Electronic Resource
    Electronic Resource
    Springer
    Experimental mechanics 32 (1992), S. 240-251 
    ISSN: 1741-2765
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The problem of using measured modal parameters to detect and locate damage in structures made of fiberreinforced composites is investigated. Recent work in this area using modal sensitivity equations is used in conjunction with internal-state variable constitutive theory to derive a set of damage-detection equations which are used to predict, from changes in measured modal parameters, the current value of the internal-state variables in each finite element. The value of the internal-state variable determines the extent of damage at a given location. Numerical examples involving damaged composite beams are used to demonstrate the capability of the theory to predict the exact location and the severity of damage. To provide experimental evidence to support the theory, mechanical and modal tests are performed on a [0,903] s laminated composite beam in the undamaged state and in three additional states of progressive damage. At each stage of damage, edge replications are taken to determine the crack density along the length of the beam. The predicted values of the internal-state variables, obtained from the modalsensitivity equations using measured modal information, are compared with the values of the internal-state variables obtained from crack-density measurements along the length of the beam. Good agreement between the predicted and the measured values is found.
    Type of Medium: Electronic Resource
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