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  • 11
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Theoretical Biology 135 (1988), S. 401-407 
    ISSN: 0022-5193
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 12
    ISSN: 1432-1084
    Keywords: MR ; Contrast enhancement ; Lymphatic system ; Neoplasms ; Contrast media ; Iron
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The inter- and intralymphonodal distribution of IV-administered superparamagnetic iron oxide (SPIO) particles as a lymphographic contrast agent for MRI was studied in various animal models in rats and rabbits. In all animals a dosage of 200 μmol Fe/kg was tested. Imaging was done at 1.5 Tesla using proton-density-weighted spin-echo (PD-SE) and T2*-weighted gradient-echo (T2*-GRE) sequences. The time course of signal loss in popliteal lymph nodes of 21 rats was studied before and up to 72 h after IV injection of SPIO. Another 6 rats were dissected 24 h after IV injection of SPIO, all lymph nodes were embedded in agar gel and imaged ex vivo. Time course and pattern of lymph node signal loss was studied in 6 rabbits with reactive lymph node hyperplasia. The visualization of lymph node metastases was studied in 4 VX2 tumor-bearing rabbits. Most pronounced signal loss in lymph nodes was found 24 h after IV injection of SPIO with a decrease of signal in popliteal lymph nodes to 37 ± 15% (9 ± 5%) for rats and 56 ± 10% (16 ± 9%) for rabbits with the PD-SE (T2*-GRE) sequence. Ex vivo examinations of rat lymph nodes and in vivo examinations in rabbits with lymph node hyperplasia demonstrated marked variations in contrast agent accumulation between different lymph node groups. In VX2 tumor-bearing rabbits lymph node metastases could be well delineated in postcontrast MRI if a sufficient amount of contrast agent reached the lymph nodes (2 rabbits). Inhomogeneous signal loss as well as supersaturation impeded correct lymph node assessment (2 rabbits). We conclude that IV MR lymphography using SPIO may be an approach for non invasive tumor staging, but this new technique could be limited by variations in contrast agent distribution between different lymph node groups.
    Type of Medium: Electronic Resource
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  • 13
    Electronic Resource
    Electronic Resource
    Springer
    European biophysics journal 7 (1981), S. 255-255 
    ISSN: 1432-1017
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Type of Medium: Electronic Resource
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  • 14
    ISSN: 1432-1459
    Keywords: Erythrocyte ghosts ; Huntington's disease ; Membrane permeability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zur Messung der Wasserpermeation durch Membranen menschlicher Erythrocyten-Ghosts wird eine kürzlich entwickelte Methode eingesetzt. Die Methode, die auf dem Unterschied der Brechungsindices von H2O und D2O beruht, wird kurz beschrieben. Vergleichende Messungen an Erythrocyten-Ghosts normaler Spender und Patienten, die an Chorea Huntington erkrankt sind, wurden durchgeführt. Die berechneten Permeabilitätskoeffizienten sind für die beiden Gruppen nahezu identisch und erlauben keine Differenzierung zwischen Kontrollpersonen und Chorea-Huntington-Patienten.
    Notes: Summary A recently developed technique is used to study the permeation of water through membranes of human erythrocyte ghosts. The method, based on the difference of the indices of refraction of H2O and D2O, is briefly described. Comparative measurements on erythrocyte ghosts from normal donors and from patients with Huntington's disease were performed. The calculated permeability coefficients for the two groups were almost identical and did not allow differentiation between the controls and patients with Huntington's disease.
    Type of Medium: Electronic Resource
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