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  • 11
    Electronic Resource
    Electronic Resource
    Raman and luminescence processes under the resonant two-photon excitation of an excitonic molecule in CuCl
    Amsterdam : Elsevier
    Solid State Communications 27 (1978), S. 785-788 
    Details
    ISSN: 0038-1098
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0038-1098(78)90697-X
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  • 12
    Electronic Resource
    Electronic Resource
    Characterization of the 5′-flanking region and chromosomal assignment of the human brain natriuretic peptide gene (1995)
    Springer
    Journal of molecular medicine 73 (1995), S. 457-463 
    Details
    ISSN: 1432-1440
    Keywords: Atrial natriuretic peptide ; Brain natriuretic peptide ; Cardiac hormone ; Chromosomal assignment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Brain natriuretic peptide (BNP) is a cardiac hormone that occurs predominantly in the ventricle, and synthesis and secretion of BNP are greatly augmented in patients with congestive heart failure and in animal models of ventricular hypertrophy. In order to elucidate the molecular mechanisms underlying the human BNP gene expression in the heart, the human BNP gene was isolated from a size-selected genomic minilibrary. The 1.9-kb human BNP 5′-flanking region (−1813 to +110) contained an array of putative cis-acting regulatory elements. Various lengths of the cloned 5′-flanking sequences were linked upstream to the bacterial chloramphenicol acetyltransferase (CAT) gene, and their promoter activities were assayed. The 1.9-kb promoter region showed a high-level CAT activity in cultured neonatal rat ventricular cardiocytes. When the CT-rich sequences (−1288 to −1095) were deleted, the high-level activity was reduced to approximately 30%. The 399-bp BNP 5′ flanking region (−289 to +110) showed approximately 10% activity of the 1.9-kb region. Furthermore, using human-rodent somatic hybrid cell lines, the BNP gene was assigned to human chromosome 1, on which the atrial natriuretic peptide gene is localized. The present study leads to a better understanding of the molecular mechanisms for the human BNP gene expression in the heart.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00202264
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    Paper (German National Licenses)
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  • 13
    Electronic Resource
    Electronic Resource
    Gene expression of the human prostaglandin E receptor EP4 subtype: differential regulation in monocytoid and lymphoid lineage cells by phorbol ester (1996)
    Springer
    Journal of molecular medicine 74 (1996), S. 333-336 
    Details
    ISSN: 1432-1440
    Keywords: Key words Prostaglandin E receptor ; EP4 subtype ; THP-1 ; Cyclic AMP ; Phorbol myristate acetate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We isolated a cDNA clone encoding the human prostaglandin (PG) E receptor EP4 subtype and examined the gene expression in human blood cells. Northern blot analysis revealed that the EP4 gene is expressed at a high level in peripheral blood mononuclear cells, and at lower levels in cultured human blood cell lines, THP-1 and U937 (monocytoid cell lines), MOLT-4 and Jurkat (T-cell lines), and Raji (B-cell line). To examine regulation of the EP4 gene expression in the immune system, we studied the effects of phorbol 12-myristate 13-acetate (PMA) on these cell lines. Gene expression was upregulated in THP-1, U937, and Raji cells by PMA, and was downregulated in MOLT-4 and Jurkat cells. In THP-1 cells the effects of PMA were further analyzed, and the upregulation of the EP4 gene was shown to be followed by an increase in PGE2 binding sites and in PGE2-induced cAMP accumulation. In the striking contrast, other PGE receptor subtypes (EP1, EP2 and EP3) and other prostanoid receptors (IP and DP) were shown not to be upregulated by PMA. Therefore, this is the first demonstration of a highly specific upregulation of the EP4 subtype in THP-1 cells treated with PMA, suggesting the importance of the EP4 subtype in the immune system. In the present study we also clarified that EP4 gene expression is regulated differently among human monocytoid and lymphoid lineage cells, thus leading to the better understanding of the regulatory mechanisms for the human EP4 gene expression in the immune system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001090050034
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  • 14
    Electronic Resource
    Electronic Resource
    A simplified set-up for clinical electroretinography. The ERG recorded at high stimulus and adaptation levels (1964)
    Springer
    Documenta ophthalmologica 18 (1964), S. 462-472 
    Details
    ISSN: 1573-2622
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les auteurs se sont servis d'un électrocardiographe portable, d'un photoflash et d'un appareil pour photographier le fond de l'oeil comme photostimulateur pour l'enregistrement de l'ERG dans la clinique. Les altérations dans l'ERG sont décrites, suivant les changements dans le stimulus et le niveau d'adaptation à la lumière concernant la dimension, l'intensité et la couleur des stimuli.
    Abstract: Zusammenfassung Die Autoren beschreiben eine einfache klinische Aufstellung, welche aus einem EKG Apparat und einem Photoblitz besteht. Eine Funduskamera hat sich als Reizapparatur für klinische Elektroretinographie sehr geeignet erwiesen. Das ERG wird diskutiert bezüglich der Änderungen in der Grösse, Intensität und Farbe der Lichtreize und des retinales Adaptationszustandes.
    Notes: Summary A simplified set-up for clinical electroretinography is described consisting of a portable ECG apparatus and a xenon flash unit. Special attention is paid to the electroretinographic responses found under very strong light conditions obtained with the fundus camera. The ERGs recorded at different levels of light adaptation, strength and wavelength of stimuli and background are discussed as well as the ERG changes recorded in the initial stage of dark adaptation after different levels of preadaptation. Finally, the ERG recorded under local retinal stimulation is discussed. The results obtained indicate the ample possibilities for clinical application of these techniques. By letting the retina shout, rather than murmur, the signal-to-noise ratio can be increased at least in a number of cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00160598
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    Paper (German National Licenses)
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