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  • 11
    Electronic Resource
    Electronic Resource
    The effects of isoprenaline and tyramine on the 45calcium uptake, the total calcium content and the contraction force of isolated guinea-pig atria in dependence on different extracellular hydrogen ion concentrations (1972)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 274 (1972), S. 125-137 
    Details
    ISSN: 1432-1912
    Keywords: Sympathomimetic Amines ; pH ; 45Calcium Uptake ; Contraction Force ; Guinea-Pig Atria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Isolated, electrically stimulated left guinea-pig atria were incubated at 30° C in a Tyrode solution, the hydrogen ion concentration of which was varied by altering the percentage of the aerating CO2/O2-mixture. The increase of the extracellular hydrogen ion concentration from pH 8.0 to pH 7.0 caused a reduction of the 45calcium uptake and of the contraction force. The positive inotropic effect and the concomitantly occuring increased 45calcium uptake induced by isoprenaline and tyramine were markedly diminished at the lower pH, the response to tyramine being more affected by increased hydrogen ion concentration than that of isoprenaline. This is possibly due to a decrease in noradrenaline available at pH 7.0 for release by tyramine. Isoprenaline and tyramine enhanced the relative specific 45calcium activity (RSA) without altering the total tissue calcium content. On the contrary, the increase of the extracellular calcium concentration caused an augmentation of the relative specific 45calcium activity and the total tissue calcium content.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00501847
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  • 12
    Electronic Resource
    Electronic Resource
    Effects of k-strophanthin and digitoxigenin on contractile force, calcium content and exchange in guinea-pig isolated atria (1972)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 275 (1972), S. 359-371 
    Details
    ISSN: 1432-1912
    Keywords: k-Strophanthin ; Digitoxigenin ; 45Calcium ; Contractile Force ; Cellular Calcium Content
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of positive inotropic and of toxic concentrations of k-strophanthin and digitoxigenin on contractile force, calcium content and 45calcium exchange was studied in isolated guinea-pig atria; at the same time the extracellular space of each preparation was determined. 1. In the concentration range used (0.8–13.4 μM) the two agents did not show any effect on the extracellular space. 2. Positive inotropic concentrations of k-strophanthin and digitoxigenin induced a significant decrease in the cellular calcium content as a result of a net increase in calcium efflux. At 3, 5, 10 or 15 min after the addition of the drug the relative specific 45calcium activity (RSA) was increased and was significantly greater than values obtained in control experiments. It is concluded that positive inotropic concentrations enlarge the exchangeable calcium fraction of the myocardial cell. 3a. During the initial positive inotropic phase of action of toxic concentrations of k-strophanthin (2.67 and 13.4 μM) and digitoxigenin (2.67 μM) there was also a significant decrease of the cellular calcium content, which occured more rapidly than that produced by positive inotropic concentrations. 3b. After the occurrence of toxic signs the calcium content of the myocardial cell was significantly increased while the unexchanged calcium fraction remained unchanged in absolute size. The RSA was always significantly increased compared with results from control experiments. It is concluded that the action of toxic concentrations of k-strophanthin and digitoxigenin on the calcium metabolism is due to a marked reduction in calcium efflux. 4. Digitoxigenin increased the contractile force considerably more than k-strophanthin, but had less effect on calcium metabolism. The difference might be due to the different lipophilic properties of the two agents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00501125
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  • 13
    Electronic Resource
    Electronic Resource
    Über die Zersetzung von Schwefelchlorür mit Wasser (1925)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 146 (1925), S. 239-262 
    Details
    ISSN: 0863-1786
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19251460118
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  • 14
    Electronic Resource
    Electronic Resource
    Ueber eine neue Darstellung von Kohlenoxyd (1883)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 16 (1883), S. 75-76 
    Details
    ISSN: 0365-9496
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.18830160126
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