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  • 11
    Electronic Resource
    Electronic Resource
    Evidence for the in vivo coating of a polyoma virus-induced tumor with antibodies specifically bound to their target-antigen (1978)
    Springer
    Cancer immunology immunotherapy 4 (1978), S. 171-177 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We made a comparative study of the in vivo binding of immunoglobulins (Ig) to a polyoma virus-induced ascitic tumor propagated in syngeneic or allogeneic mice. The Ig coat was found to appear more rapidly and to be denser in H 2-incompatible than in H 2-compatible mice. This suggests that antibodies were fixed specifically on strong normal transplantation antigens (H-2) recognized as non-self by allogeneic mice. Experiments with mice in which immunosuppression had been achieved by means of X-irradiation confirmed that the Ig fixed on SEWA cells are actively bound antibodies. The only mice that could fix Ig on tumor cells were those that had been specifically immunized against cell surface antigens shared by SEWA cells before irradiation, while mice hyperimmunized against nonrelated antigens could not.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00204736
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    Paper (German National Licenses)
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  • 12
    Electronic Resource
    Electronic Resource
    Effect of serum from tumor-bearing mice on the in vitro migration of thymocytes (1972)
    Springer
    Cellular and molecular life sciences 28 (1972), S. 1354-1356 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé La migration in vitro, hors de tubes capillaires, des thymocytes de souris est plus importante en présence du sérum de souris porteuses d'une tumeur syngénique transplantée chimio-induite qu'en présence de sérum normal. Ce phénomène, qui est fonction du poids de la tumeur, pourrait être en rapport avec l'involution thymique accompagnant la croissance tumorale.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01965342
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    Paper (German National Licenses)
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  • 13
    Electronic Resource
    Electronic Resource
    Synthetic peptides corresponding to the F protein of RSV stimulate murine B and T cells but fail to confer protection (1991)
    Springer
    Archives of virology 117 (1991), S. 59-71 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have previously located a major neutralization site of the fusion protein of respiratory syncytial virus (RSV) in the polypeptide region extending from amino acids Ile221 to Glu232. In this report, 8 peptides corresponding to the six major hydrophilic regions of the F1 subunit were selected to analyse their immunogenic and protective capacities as well as their ability to block the high neutralization activities of 4 monoclonal antibodies (MAbs). Only 5 of the 8 peptides tested induced specific antibodies while all induced an in vitro interleukin-2 response of splenocytes from immunized mice. Peptide 3 (Ile221-Phe237) was able to elicit neutralizing antibodies, confirming our previous hypothesis concerning the location of a neutralization site. However, immunization with the latter did not induce significant reduction of virus in lungs of BALB/c mice upon challenge, probably due to an inadequate level of circulating neutralizing antibodies. Interestingly, peptides 2 (Asn216-Glu232), 3 (Ile221-Phe237), and 5 (Ser275-Ile288) blocked in vitro neutralization by four different F1 specific MAbs. A hypothesis is proposed to explain these results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01310492
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    Paper (German National Licenses)
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  • 14
    Electronic Resource
    Electronic Resource
    Protection from mouse hepatitis virus type 3-induced acute disease by an anti-nucleoprotein monoclonal antibody (1987)
    Springer
    Archives of virology 97 (1987), S. 123-130 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fusion of MHV-3-immune splenocytes from MHV-3-resistant A/J murine strain, with NS myeloma cells produced several hybridomas. Among eight hybridoma clones, the 1E7A4H1 clone secreted kappa IgG2a apparently directed against the nucleoprotein of the MHV-3 virion. The monoclonal antibody was able to neutralize the in vitro cytopathic effect of MHV-3 on cultured L2 cells, and was detected by indirect immuno-fluorescence on MHV-3-infected cultured YAC cells. In addition, it conferred a significant protection against MHV-3-induced acute disease, if injected intraperitoneally to C57BL/6 mice before inoculation with MHV-3.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01310740
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    Paper (German National Licenses)
    Fulltext
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