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  • 11
    Electronic Resource
    Electronic Resource
    Blood markers of early and late airway responses to allergen in asthmatic subjects. Relationship with functional findings (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 52 (1997), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We evaluated the relationship between blood markers of mast-cell (plasma histamine and serum level of heat-stable neutrophil chemotactic activity [NCA]) and eosinophil (serum eosinophil cationic protein [ECP]) activation during early airway response (EAR) and late airway response (LAR) to allergen inhalation in 24 asthmatic subjects. After EAR, 14 subjects showed significant LAR (FEV1 fall: 〈inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:01054538:ALL32:ges" location="ges.gif"/〉25%), while 10 subjects showed equivocal LAR (FEV1 fall: 15–20%). A significant increase from baseline value was observed in plasma histamine and in serum NCA during both EAR and LAR, while serum ECP significantly increased only during LAR. The sensitivity of different markers to detect significant FEV1 fall during EAR and LAR was low, except for NCA. Changes in blood mediators were similar in both groups with significant and equivocal LAR. There was a significant relationship between the increase in NCA during EAR and the severity of LAR. Stepwise regression between changes in different blood markers showed a significant relationship between histamine increase during EAR and ECP increase during LAR. Thus, serum NCA is a more sensitive marker of EAR and LAR than plasma histamine and serum ECP, and its increase during EAR seems predictive of the severity of the subsequent LAR.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1997.tb02543.x
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  • 12
    Electronic Resource
    Electronic Resource
    Specific inhalation challenge with wheat flour in workers with suspected baker's asthma (1999)
    Springer
    International archives of occupational and environmental health 72 (1999), S. 335-337 
    Details
    ISSN: 1432-1246
    Keywords: Key words Baker's asthma ; Specific inhalation challenge test ; Airborne wheat flour dust
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: The aim of this study was to evaluate the outcome of the specific inhalation challenge test (SIC) in 160 subjects with suspected baker's asthma and to assess its relation to total flour dust levels and to personal characteristics such as specific skin sensitisation, non-specific bronchial hyper-responsiveness (NSBH) and atopy. Methods: We investigated the outcome of SIC tests performed with wheat flour in six Italian laboratories. For each subject, data was available regarding skin sensitisation to wheat flour, NSBH, atopy, forced expiratory volume at 1 s (FEV1) monitoring and airborne flour dust in the challenge chamber measured by the gravimetric method (total dust in mg/m3). Results: The SIC test was positive for early asthma in 42 subjects (26%) and for late/dual asthma in 18 (11%). Positive outcome to SIC was significantly associated with NBSH (odds ratio, OR: 3.5, 95% CI: 1.6–7.7) and skin sensitisation to wheat flour (OR: 3.1, 95% CI: 1.3–7.0). Exposure level to wheat flour was less than or equal to 10 mg/m3 in 12% of individuals, ranged between 11 and 30 mg/m3 in 43% and exceeded 30 mg/m3 in 45%. The outcome of SIC was always negative among workers not skin sensitised to wheat flour and without NSBH and atopy. An increasing prevalence of positive SIC was observed among workers with one or more of the above-mentioned personal characteristics whose challenge exposure was greater than 10 mg/m3 (P 〈 0.001). Conclusion: Procedures currently adopted for wheat flour dust exposure during SIC need to be better standardised in order to avoid excessive airborne dust exposure. Over-exposure seems to be of no use for the diagnosis and risks making the asthmatic reaction worse, particularly in patients who are both sensitised to wheat allergens and have NSBH and/or atopy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004200050384
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  • 13
    Electronic Resource
    Electronic Resource
    The free erythrocyte protoporphyrin assay in monitoring lead-exposed workers (1980)
    Springer
    International archives of occupational and environmental health 45 (1980), S. 35-48 
    Details
    ISSN: 1432-1246
    Keywords: Lead intoxication ; Free erythrocyte protoporphyrin ; Fluorometric analysis ; Hematofluorometer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have performed a comparative analysis of two different fluorometric methods used to determine free erythrocyte protoporphyrin (FEP) blood concentration. The first method is based on an extractive procedure, whereas the second one involves the direct fluorometric analysis of whole blood. Our results show that the extractive procedure is probably the most reliable technique available for FEP determination, but it is not so suitable for mass screening, whereas the direct fluorometric determination of FEP blood concentration is probably less reliable, but sufficiently enough to be used for mass screening. We have furthermore investigated whether the FEP test could be used as a unique monitoring method for subclinical lead poisoning. Our findings indicate that FEP test can detect very early metabolic alterations, but it is not so suitable for determining lead absorption and should therefore be used in mass screening together with a dose indicator, such as blood lead concentration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00378094
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  • 14
    Electronic Resource
    Electronic Resource
    High-performance liquid chromatography for the quantitative determination of the urinary metabolites of toluene, xylene, and styrene (1982)
    Springer
    International archives of occupational and environmental health 50 (1982), S. 25-31 
    Details
    ISSN: 1432-1246
    Keywords: Toluene ; Xylene ; Styrene ; Hippuric acid ; m-Methylhippuric acid ; Phenylglyoxylic acid ; Mandelic acid ; Urinary metabolites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A new high-pressure liquid chromatography (HPLC) method for simultaneous quantitative determination of the urinary metabolites of toluene, m-xylene, and styrene (hippuric acid, m-methylhippuric acid, phenylglyoxylic acid, mandelic acid) is described. The extraction procedure was performed on acidified urines, after addition of 4-hydroxybenzoic acid as internal standard, using a butylchloride/isopropanol mixture and drying 0.5 ml of the organic layer under nitrogen flow. The residue obtained was dissolved in 0.1 ml water/acetonitrile and 5 μl were injected into an HPLC apparatus equipped with a 0.26 × 25 cm HC ODS SIL X column. Absorbance measures were performed at 225 nm throughout the investigation. All metabolites were clearly separated in a short time (12 min) and the amounts of other urinary compounds affecting the analysis were so small that the measurement of low concentrations of the urinary metabolites could be easily performed. Linear calibration curves were obtained from 0.1 to 3 mg/ml and a correlation coefficient greater than 0.99 was found between concentrations of the standards and areas of the peaks. Statistical analysis confirms that this method, which has a high reproducibility, is simple, reliable, and useful for the biologic monitoring of industrial exposure to aromatic compounds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432491
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  • 15
    Electronic Resource
    Electronic Resource
    Toxic myopathy induced by industrial minerals oils: Clinical and histopathological features (1986)
    Springer
    Neurological sciences 7 (1986), S. 599-604 
    Details
    ISSN: 1590-3478
    Keywords: Myopathy ; toxic agents ; mineral oils
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Viene descritto un caso di miopatia subacuta insorta in un uomo di 47 anni addetto alla manutenzione e pulizia delle caldaie di combustione di una centrale termoelettrica. L'anamnesi lavorativa mette in risalto la rilevanza dell'esposizione all'inalazione delle ceneri, derivate dalla combustione di oli minerali e contenenti vari elementi, metalli e metalloidi, tra cui in particolare vanadio e nichel. La sintomatologia d'esordio, il decorso clinico ed i dati istopatologici muscolari suggeriscono come l'esposizione al tossico abbia una verosimile importanza nella determinazione del quadro.
    Notes: Abstract We report a case of subacute myopathy in a 47 years old man engaged on boiler maintenance at an oil-fired thermoelectric power station. The occupational history highlighted heavy exposure to inhalation of ash derived from mineral oil combustion and containing several elements, metals and metalloids, including vanadium and nickel. The presenting symptoms, clinical course and muscle histopathology suggest that exposure to toxic agents probably played an important part in the causation of the myopathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02341474
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