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  • 11
    Electronic Resource
    Electronic Resource
    Directct Epicardial Mapping Can Differentiate Hibernating from Scarred Myocardium: A Validation Study with 18F-FDG-PET (2002)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of noninvasive electrocardiology 7 (2002), S. 0 
    Details
    ISSN: 1542-474X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim: This study investigated the value of epicardial mapping immediately before CABG in the differentiation of hibernating from scarred myocardium in correlation to the noninvasive gold standard 18F-FDG PET.Methods and Results: In 35 patients with CAD, myocardial perfusion (99mTc-Tetrofosmin-SPECT), viability (18F-FDG-PET), and function (LVangiography) were assessed before CABG. 102 bipolar epicardial electrograms per patient (n = 3570 electrograms) were recorded simultaneously with a ventricular jacket array. Based on the scintigraphic and LV angiographic data at the site of each electrode with good myocardial contact (n = 1963), segments (n = 492, 14.1 ± 5.6 per patient; mean ± SD) were classified into three groups: hibernating (n = 139), scarred (n = 104), and control (n = 249). Regional mean bipolar voltage values were calculated for Receiver Operating Characteristic (ROC) analysis. Mean bipolar voltage was significantly lower in scarred when compared to hibernating myocardium. ROC curve analysis (area under the curve of O.92 ± 0.47, mean ± SE) for mean bipolar voltage to discriminate between hibernating and scarred myocardium revealed a sensitivity of 94% with a specificity of 83% at a cut-off value of 8.75 mV.Conclusion: Hibernating myocardium can be differentiated correctly from scarred myocardium by direct epicardial mapping. In the future, hibernating myocardium may be detectable by body surface mapping techniques using inverse solutions. A.N.E. 2002;7(4):349–356
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1542-474X.2002.tb00184.x
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  • 12
    Electronic Resource
    Electronic Resource
    High-Temperature Proton Conductors for the Injection of Hydrogen into a Vacuum (2001)
    Westerville, Ohio : American Ceramics Society
    Journal of the American Ceramic Society 84 (2001), S. 0 
    Details
    ISSN: 1551-2916
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Tubes of ceramic high-temperature proton conductors (CaZr0.9In0.1O3−x,BaZr0.9Y0.1O3−x, and Ba3Ca1.18Nb1.82O9−x)were used to introduce hydrogen into a vacuum system. A prerequisite was a leak rate below 10−8mbar/s for an assembly consisting of the active tube and a 8YSZ support tube. Mass spectrometry showed that the partial pressure of hydrogen in the vacuum system, pH2, increased linearly with the electric current flowing through the proton conductor. All other important partial pressures remained unaffected by this operation. Calculation of throughput during operation of the hydrogen source essentially revealed that the total current, J, is used to transport protons from the anode to the cathode (tH∼ 1). The number of moles of H2 transported per second is given by J/2F. In essence, the present proton conductor tube constitutes a precise, current-controllable device, with a response time of a few seconds only, that delivers ultrahigh-purity hydrogen to a vacuum system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1151-2916.2001.tb00948.x
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  • 13
    Electronic Resource
    Electronic Resource
    Heavy-Water (D2O) Take-Up-Induced Lattice Expansion in the High-Temperature Proton Conductor Ba3Ca1.18Nb1.82O9−δ (1997)
    Westerville, Ohio : American Ceramics Society
    Journal of the American Ceramic Society 80 (1997), S. 0 
    Details
    ISSN: 1551-2916
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Dimensional changes of the high-temperature proton conductor Ba3Ca1.18Nb1.82O9−δ, when exposed to D2O vapor, were investigated using length-change and precision density measurements. Such information is essential for possible applications of proton conductors in solid oxide fuel cells and humidity and hydrogen sensors. A linear increase of the sample lengths with increases in the deuterium content was observed. Comparison of the present D2O data with those that were previously obtained for H2O showed that there was a small isotope effect in the lattice expansion. The fact that the length-change-versus-hydrogen-isotope-concentration curves were almost isotope independent supported the validity of the take-up reaction H2O(g) + VOö+ OxO is an ⇄ 2OHO. In regard to the latter equation, it was found that small islands of silver, palladium, nickel, and platinum act as catalytic promoters of the reaction and lead, for given heavy-water-steam exposure conditions, to an increase of water absorption of up to 100%, when compared with samples without the catalytic surface layers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1151-2916.1997.tb03268.x
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  • 14
    Electronic Resource
    Electronic Resource
    The High-Temperature Proton Conductor Strontium Zirconate: Thermogravimetry of Water Uptake (1997)
    Westerville, Ohio : American Ceramics Society
    Journal of the American Ceramic Society 80 (1997), S. 0 
    Details
    ISSN: 1551-2916
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The water uptake of nominally 5%-Yb-doped strontium zirconate (SrZr0.95Yb0.05O3−α) was studied in situ by thermogravimetry at different temperatures and water vapor pressures. The process could be described in terms of an ideal solution behavior, showing a lower effective vacancy concentration than that expected from the nominal dopant content. The solution reaction was found to have ΔS°=−127 J/(mol·K) and ΔH°=−106 kJ/mol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1151-2916.1997.tb02902.x
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  • 15
    Electronic Resource
    Electronic Resource
    Characterization of 3-[123I]iodo-L-α-methyl tyrosine transport in astrocytes of neonatal rats (2001)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 76 (2001), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 3-[123I]Iodo-L-α-methyl tyrosine (123I-IMT) is used for diagnosis and monitoring of brain tumours by means of single-photon emission tomography. As recently shown, 123I-IMT is predominantly mediated into rat C6 glioma cells by sodium-independent system L for large neutral amino acids. Until now, 123I-IMT transport in non-neoplastic glial cells has not been examined. Therefore, the aim of this study was to examine the cellular pathways and precise transport kinetics of 123I-IMT uptake into astrocytes of neonatal rats. In particular sodium-independent 123I-IMT transport into neonatal astrocytes was compared with sodium-independent 123I-IMT uptake into neoplastic rat C6 glioma cells.Competitive inhibition experiments showed that 123I-IMT is exclusively transported via sodium-independent system L into the neonatal astrocytes (92%). Kinetic analysis of sodium-independent 123I-IMT uptake into neonatal astrocytes and into C6 glioma cells revealed apparent Michaelis constants KM = 13.9 ± 0.5 µm and KM = 33.9 ± 4.1 µm, respectively, which are in the same range of KM values as those recently determined for amino acid transport into neoplastic and non-neoplastic glial cells. Indeed, the KM values in the micromolar range correspond to the expression of the LAT-1 subunit of system L both in the neonatal astrocytes and in C6 glioma cells. However, sodium-independent maximum transport velocities (Vmax) differed significantly between neonatal astrocytes and C6 glioma cells (11.1 ± 0.3 and 39.9 ± 3.3 nmol/mg protein/10 min, respectively).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2001.00048.x
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  • 16
    Electronic Resource
    Electronic Resource
    Hydrogen blisters on β-NbD after laser pulse heating (1994)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 76 (1994), S. 2093-2096 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Plates of β-NbD0.7 were irradiated with single pulses of a KrF excimer laser having a wavelength of 248.4 nm. The power level was varied from roughly 0.1 to 1 GW/cm2. The pulse length was about 15 ns. The irradiated areas at low and medium power displayed individual hydrogen (deuterium) blisters which started overlapping at higher power levels. Calculation of the thermal diffusivity showed that a surface layer roughly 0.6 μm thick was heated during the pulse. Applying Bechtel's formula [J. Appl. Phys. 46, 1585 (1975)] for the temperature increase in the heated layer demonstrated that melting of the heated layer must have occurred during the pulse. The formation of hydrogen (deuterium) blisters is understandable in terms of the very high equilibrium vapor pressure of the hydrides near the melting temperature. A model for the formation of the blisters is presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.357619
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  • 17
    Electronic Resource
    Electronic Resource
    The aging of niobium and tantalum tritides: Evolution of hardness in comparison with other properties (1989)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 65 (1989), S. 117-121 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Vickers hardness measurements on niobium and tantalum tritides of initial composition NbT0.0225 and TaT0.097, respectively, performed over the first 20 months after T charging, are reported and interpreted. For both tritides, the hardness increases monotonically, but in a decelerating rate, with the 3 He concentration built up upon T transmutation. At given 3 He concentration, the increase per unit 3 He concentration is stronger for Nb than for Ta. To interpret the observed hardness evolution, existing hardening theories are adjusted to the present microstructural situations. It is concluded that the microstructure developing on 3 He precipitation is more disperse in the Nb tritide than in the Ta tritide. These findings are supported by conclusions drawn previously from swelling, acoustic emission, and x-ray diffraction measurements of these materials.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.342584
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  • 18
    Electronic Resource
    Electronic Resource
    Single photon emission computed tomography (SPECT) with 99mTc-HMPAO (hexamethyl propylenamino oxime) in chronic paroxysmal hemicrania-a case report (1990)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 10 (1990), S. 0 
    Details
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The case of a 69-year-old woman with chronic paroxysmal hemicrania (CPH) is presented in whom cerebral perfusion was investigated using the flow tracer 99mTc-hexamethyl propylenamino oxime (HMPAO) and single photon emission tomography (SPECT). There was a bilateral hypoperfusion in the fronto-parietal region between attacks-without medication as well as under effective treatment with verapamil. During an attack, however, SPECT investigation showed a normal cerebral perfusion. Further investigation is required to find out whether these SPECT findings are due to primary alterations of brain perfusion in CPH or are only of epiphenomenological nature. The observed effectiveness of verapamil in the prophylactic treatment of CPH should be verified in a greater number of patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-2982.1990.1006311.x
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  • 19
    Electronic Resource
    Electronic Resource
    High throughput screening by multichannel glass fiber fluorimetry (1997)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 68 (1997), S. 2187-2194 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: As a tool for screening large numbers of biological samples by means of amplification (e.g., Qβ or PCR) we have constructed a thermocycler that includes optionally a 96-channel or 960-channel glass fiber fluorimeter (combined with a cooled charge-coupled-device camera). We briefly describe the system integration of all components like liquid handling, thermostats, an x,y,z robot arm, and the glass fiber fluorimeter. The integrated glass fiber fluorimeter allows sensitive on-line measurements in 960 channels within 5 s. Two different screening procedures were carried out. In a first experiment PCR reactions were done in the presence of the known PCR inhibitor hematin and its suppressor transferrin. The system was used to titrate the suppressor with the inhibitor hematin in order to determine the maximum inhibitor concentration tolerated at a given suppressor concentration. We processed 96 PCR samples in parallel with 11 different concentration steps. In a second experiment the 960-channel glass fiber fluorimeter was used to monitor on line the amplification of the Qβ system in the presence or absence of an inhibitor (heparin). Since the doubling time of Qβ RNA variants is about 20 s, on-line detection is crucial for the experimental setup. The evolution of new RNA species adapted to high inhibitor concentrations could be proved by comparison of the fluorimetric signal and electrophoresis. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1148110
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  • 20
    Electronic Resource
    Electronic Resource
    Gas-handling system of a gas chromatograph for the purity control of tritium gas (1987)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 58 (1987), S. 1116-1117 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The gas-handling system of a simple, inexpensive gas chromatograph is described suitable for the safe and fast purity analysis of tritium gas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1139619
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