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  • 11
    Electronic Resource
    Electronic Resource
    PI 3-kinase p110β: a new target for antithrombotic therapy (2005)
    [s.l.] : Nature Publishing Group
    Nature medicine 11 (2005), S. 507-514 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Platelet activation at sites of vascular injury is essential for the arrest of bleeding; however, excessive platelet accumulation at regions of atherosclerotic plaque rupture can result in the development of arterial thrombi, precipitating diseases such as acute myocardial infarction and ischemic ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm1232
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  • 12
    Electronic Resource
    Electronic Resource
    Essential role for collectrin in renal amino acid transport (2006)
    [s.l.] : Nature Publishing Group
    Nature 444 (2006), S. 1088-1091 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Angiotensin -converting enzyme 2 (ACE2) is a regulator of the renin angiotensin system involved in acute lung failure, cardiovascular functions and severe acute respiratory syndrome (SARS) infections in mammals. A gene encoding a homologue to ACE2, termed collectrin (Tmem27), has been ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature05475
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  • 13
    Electronic Resource
    Electronic Resource
    Ultrasonographic evaluation of the cervical lymph nodes in preoperative staging of esophageal neoplasms (1998)
    Springer
    Abdominal imaging 23 (1998), S. 275-277 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Ultrasound—Esophageal cancer—Cervical lymph node metastasis.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Background: The detection of cervical lymph node metastases plays an important role in staging of patients affected by esophageal cancer to perform the best therapeutic approach. Methods: We report our experience concerning the ultrasound evaluation of the cervical area in 174 patients with esophageal cancer. Ultrasonographic evaluation of the neck can be done with a 7.5- or 10 MHz transducer in all cases, with selective scanning of the lymph node chains of the internal jugular veins and supraclavicular regions. The short-to-long axis ratio (S/L) was a useful way to detect lymph node metastasis. Histopathologic diagnoses were obtained by sonographically guided fine-needle aspiration biopsy. Results: At ultrasound examination, we found 18 (10.3%) patients with metastatic cervical nodes. Of these, 17 (94.4%) had metastatic cervical lymph nodes confirmed by cytology from fine-needle biopsy. Lymph node exceeding 5 mm in long axis and with an S/L over 0.5 showed a higher incidence of metastasis than those with an S/L under 0.5. Our experience shows a high incidence of lymph node metastases in patients with esophageal cancer localized to the thoracic supracarinal tract and in patients with cervical and lower esophageal cancer. Conclusion: In the ultrasound evaluation of nodes, the most useful parameters are size of nodes, heterogeneity of internal echoes, morphology of the margins, and the deformation caused by compressive instrumental manipulation. These criteria, indicated by the Japanese Society for Esophageal Diseases, yield a high sensitivity and diagnostic specificity when the ultrasonographic studies are performed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900338
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  • 14
    Electronic Resource
    Electronic Resource
    Minimally differentiated acute myeloid leukemia (AML-MO): a distinct clinico-biologic entity with poor prognosis (1996)
    Springer
    Annals of hematology 72 (1996), S. 208-215 
    Details
    ISSN: 1432-0584
    Keywords: Key words AML-M0 ; Anti-MPO ; Complex karyotypes ; MDR phenotype
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  FAB proposals for the diagnosis of AML-M0 represent the formal recognition of a distinct entity which has been described over the past few years by several authors and called minimally differentiated acute myeloid leukemia. By definition, AML-M0 includes acute leukemias which do not fit morphological and cytochemical criteria for the diagnosis of AML, and for which myeloid lineage assignment can be made by immunological assay showing positivity for MPO, CD13, and CD33 and negativity for lymphoid markers. Involvement of an early myeloid progenitor in the leukemic process is a possible theory hypothesized to explain the existence of such a form. Validity of this assumption has been based on the observation that AML-M0 frequently bears "stem cell" markers such as CD34, HLA-DR, Tdt, CD7, and promiscuous IgH/TCR gene rearrangements, which are thought to occur in uncommitted cells. Finally, AML-M0 very frequently carries cytogenetic abnormalities common to MDS or secondary AML, such as -5/5q- or -7/7q- deletions and or complex karyotype. In our experience, AML-M0 is also very often associated with the MDR phenotype, which in turn has been found strictly linked to "stem cell" features, especially in MDS. These biological aspects, altogether, translate into a very unfavorable prognosis, confirming even from a clinical point of view that AML-M0 is a distinct entity. In conclusion, "stem cell" markers, MDR phenotype, complex chromosome lesions, frequent occurrence in elderly patients, and intrinsic chemoresistance characterize AML-M0 and indicate the need for tailored treatments, possibly involving the use of MDR modulators and/or differentiating agents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050162
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  • 15
    Electronic Resource
    Electronic Resource
    Contribution of immunophenotypic and genotypic analyses to the diagnosis of acute leukemia (1995)
    Springer
    Annals of hematology 71 (1995), S. 13-27 
    Details
    ISSN: 1432-0584
    Keywords: Acute leukemia ; Diagnosis ; Immunophenotypic ; Cytogenetics ; Molecular genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Diagnostic accuracy in acute leukemia (AL) can be improved if traditional morphology and cytochemistry are supplemented with immunophenotypic and genotypic analyses. This multiparameter approach is of crucial importance for the management of patients, as it enables the identification of leukemic syndromes with distinct biological features and response to treatment. Immunophenotyping using monoclonal antibodies has been universally accepted as a useful adjunct to morphological criteria. This technique is particularly valuable in diagnosing and subclassifying acute lymphoblastic leukemia and is also essential in certain types of acute myeloid leukemia (AML), such as AML with minimal differentiation or acute megakaryoblastic leukemia. Cytogenetic findings can be quite helpful in establishing the correct diagnosis and can add information of prognostic significance. A number of specific chromosomal abnormalities have been recognized that are very closely, and sometimes uniquely, associated with morphologically and clinically distinct subsets of leukemia. An even more basic understanding of normal and malignant hematopoietic cells has begun to evolve as molecular biology begins to unravel gene misprogramming by Southern and Northern blot analysis, the polymerase chain reaction, and fluorescence in situ hybridization. With the extensive use of these techniques it has become apparent that a proportion of leukemias exhibit the biologically relevant molecular defect in the absence of a karyotypic equivalent. On the other hand, apparently uniform chromosomal abnormalities such as the t(1;19) (q23;p13), t(9;22) (q33;q11), t(8;14) (q24;q32), or t(15;17) (q21;q21) may differ at the molecular level. Data collected from these modern technologies have introduced a greater complexity, which needs to be taken into consideration to improve both the diagnostic precision and the reproducibility of current classifications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01696228
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  • 16
    Electronic Resource
    Electronic Resource
    Open sutureless tension-free repair for primary inguinal hernia (1999)
    Springer
    Hernia 3 (1999), S. 121-124 
    Details
    ISSN: 1248-9204
    Keywords: Hernioplasty ; Outpatient surgery ; Prosthetic materials
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Since the first hernioplasty performed by Edoardo Bassini in 1884, all surgical reconstruction techniques have suffered from a common defect: tension on the suture line. This represents the main etiologic factor for recurrent hernia. With the introduction of modern prosthetic materials (meshes and plugs) it is possible to perform all hernia repairs without altering the normal anatomy, as well as avoiding undesired suture line tensions. Between January 1992 and December 1998 1405 open sutureless tension-free repairs were performed for primary inguinal hernia in 1317 patients. The number of patients treated with local anesthesia was 1235 (93.8%), with 63 (4.8%) treated under general anesthesia, and 19 (1.4%) with epidural anesthesia. In this series only 4 (0.3%) cases of intra-operative complication occurred (vagal crisis without consequences for the patients). Nine (0.6%) cases of early postoperative complications were noted, of which 8 involved vagal crisis and 1 hemorrhage. Forty six (3.4%) late postoperative complications occurred: 32 seromas accompanied by 3 massive inguino-scrotal edemas, 4 hematomas, and 10 wound infections without the necessity to remove the mesh in all cases. Six recurrences (0.4%) were noted after primary surgical repair. Mean follow-up time was 4 years (range 1–7 years). The proposed technique is simple, safe, and characterized by a rapid performing procedure giving an excellent outcome. The data presented confirms the experience of others reported in the world literature, with a low complication rate and lower cost for the community.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01195309
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  • 17
    Electronic Resource
    Electronic Resource
    The effect of Spartina alterniflora Loisel on trace metals accumulation in inter-tidal sediments (1997)
    Springer
    Mangroves and salt marshes 1 (1997), S. 201-209 
    Details
    ISSN: 1572-977X
    Keywords: salt marsh ; trace metals ; sediments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We present the distribution of Cd and Zn in sediment cores taken under Spartina alterniflora Loisel. marsh and compare with adjacent mud flats without plant cover. Vertical distribution of Cd and Zn in the mud flat and S. alterniflora cores were different. From 0 to 5 cm of depth Zn and Cd concentrations did not change with depth in the two cores but were higher in the mud flat. From 5 to 15 cm, corresponding to maximum root biomass under S. alterniflora, Zn and Cd concentrations remained constant in the mud flat cores, but increased by a factor of nearly 4 under S. alterniflora. Below this depth concentrations dropped in both cores. Manganese distribution in S. alterniflora cores suggests that oxides are precipitated at the depth of maximum root biomass. More oxic environment under S. alterniflora (average Eh = +5 mV) with low sulfide concentration (0.58 mg l-1) relative to the mud flat cores (average Eh = –204 mV; sulfide 47.1 mg l-1), may favor Fe and Mn oxi-hydroxides precipitation, causing an accumulation of Cd and Zn at the root zone. In the mud flat cores, Zn and Cd highest concentrations were at the sediment water interface, where oxic waters favor their precipitation with Fe and Mn oxi-hydroxides. The results discourages the indiscriminate use of salt marsh sediments in environmental monitoring of trace metals, since the possibility of post-deposition mobilization of trace metals due to root metabolism, will make correlation with trace metal loading rates impossible.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009990604727
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  • 18
    Electronic Resource
    Electronic Resource
    A new missense mutation (Cys297→Phe) of the low density lipoprotein receptor in Italian patients with familial hypercholesterolemia (FHTrieste) (1994)
    Springer
    Human genetics 〈Berlin〉 93 (1994), S. 538-540 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract During a survey of the mutations of the low density lipoprotein receptor (LDL-R) gene in Italian patients with familial hypercholesterolemia (FH), we identified a novel point mutation, that creates a new EcoRI site at the 5′ end of exon 7, in a heterozygous FH subject (FH-100). The sequence of a cDNA fragment encompassing exon 7 showed the presence of a G→T transversion in codon 297; this created a new EcoRI site and produced a missense mutation, leading to a Cys297→Phe substitution in repeat A of the epidermal growth factor (EGF) precursor homology domain of LDL-R. Since the substitution of Cys297 disrupts the intracellular transport of the LDL-R protein, as previously demonstrated by site-directed mutagenesis, we suggest that this mutation is the cause of FH in the FH-100 proband. We screened the DNA of 303 Italian FH patients by amplification of exon 7 from genomic DNA followed by digestion with EcoRI or by Southern blotting. Two individuals (FH-64 and FH-127) were found to be carriers of the Cys297→Phe mutation. Restriction fragment length polymorphism analysis demonstrated that, in two kindreds (FH-64 and FH-100), the haplotype in linkage with the Cys297→Phe mutation was the same, suggesting the presence of a common ancestor. The Cys297→Phe mutation has been designated FHTrieste after the name of the city in Northern Italy from which probands FH-100 and FH-127 originate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00202819
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  • 19
    Electronic Resource
    Electronic Resource
    Immunohistochemical analysis of C-protein isoforms in cardiac and skeletal muscle of the axolotl, Ambystoma mexicanum (1995)
    Springer
    Cell & tissue research 282 (1995), S. 399-406 
    Details
    ISSN: 1432-0878
    Keywords: Key words: C-protein ; Isoforms ; Cardiac muscle ; Skeletal muscle ; Western blots ; Immunofluorescent microscopy ; Axolotl ; Ambystoma mexicanum (Urodela)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Of the several proteins located within sarco-meric A-bands, C-protein, a myosin binding protein (MyBP) is thought to regulate and stabilize thick filaments during assembly. This paper reports the characterization of C-protein isoforms in juvenile and adult axolotls, Ambystoma mexicanum, by means of immunofluorescent microscopy and Western blot analyses. C-protein and myosin are found specifically within the A-bands, whereas tropomyosin and α-actin are detected in the I-bands of axolotl myofibrils. The MF1 antibody prepared against the fast skeletal muscle isoform of chicken C-protein specifically recognizes a cardiac isoform (Axcard1) in juvenile and adult axolotls but does not label axolotl skeletal muscle. The ALD66 antibody, which reacts with the C-protein slow isoform in chicken, local- izes only in skeletal muscle of the axolotl. This slow axolotl isoform (Axslow) displays a heterogeneous distribution in fibers of dorsalis trunci skeletal muscle. The C315 antibody against the chicken C-protein cardiac isoform identifies a second axolotl cardiac isoform (Axcard2), which is present also in axolotl skeletal muscle. No C-protein was detected in smooth muscle of the juvenile and adult axolotl with these antibodies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004410050491
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  • 20
    Electronic Resource
    Electronic Resource
    Immunohistochemical analysis of C-protein isoforms in cardiac and skeletal muscle of the axolotl, Ambystoma mexicanum (1995)
    Springer
    Cell & tissue research 282 (1995), S. 399-406 
    Details
    ISSN: 1432-0878
    Keywords: C-protein ; Isoforms ; Cardiac muscle ; Skeletal muscle ; Western blots ; Immunofluorescent microscopy ; Axolotl, Ambystoma mexicanum (Urodela)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Of the several proteins located within sarcomeric A-bands, C-protein, a myosin binding protein (MyBP) is thought to regulate and stabilize thick filaments during assembly. This paper reports the characterization of C-protein isoforms in juvenile and adult axolotls, Ambystoma mexicanum, by means of immunofluorescent microscopy and Western blot analyses. C-protein and myosin are found specifically within the A-bands, whereas tropomyosin and α-actin are detected in the I-bands of axolotl myofibrils. The MF1 antibody prepared against the fast skeletal muscle isoform of chicken C-protein specifically recognizes a cardiac isoform (Axcard1) in juvenile and adult axolotls but does not label axolotl skeletal muscle. The ALD66 antibody, which reacts with the C-protein slow isoform in chicken, localizes only in skeletal muscle of the axolotl. This slow axolotl isoform (Axslow) displays a heterogeneous distribution in fibers of dorsalis trunci skeletal muscle. The C315 antibody against the chicken C-protein cardiac isoform identifies a second axolotl cardiac isoform (Axcard2), which is present also in axolotl skeletal muscle. No C-protein was detected in smooth muscle of the juvenile and adult axolotl with these antibodies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00318872
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