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  • 11
    Digitale Medien
    Digitale Medien
    An experimental study of vancomycin-induced cochlear damage (1989)
    Springer
    European archives of oto-rhino-laryngology and head & neck 246 (1989), S. 67-70 
    Details
    ISSN: 1434-4726
    Schlagwort(e): Ototoxicity ; Vancomycin ; Mongolian gerbil ; Evoked response audiometry ; Scanning electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Vancomycin has been successfully used clinically for many years. Although early reports found ototoxicity to be a side effect of this antibiotic, later studies could not confirm this. For this reason we have started an experimental study in an animal model on the ototoxic effects of vancomycin. We now report the results of this study. Fourteen healthy Mongolian gerbils were treated with intraperitoneal injections of vancomycin (80 mg/kg per day) for a 2-week period. Before and after treatment each animal's hearing was evaluated by evoked response audiometry. Post mortem the cochleae were investigated by scanning electron microscopy in Amsterdam and by microdissection with surface preparations (hair cell counting) in Stockholm. The results of this study show that there is no clear evidence for the existence of ototoxicity due to vancomycin in this dosage.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00457456
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  • 12
    Digitale Medien
    Digitale Medien
    The vascular anatomy of the spiral lamina and the spiral limbus in the adult rat (1986)
    Springer
    European archives of oto-rhino-laryngology and head & neck 243 (1986), S. 24-26 
    Details
    ISSN: 1434-4726
    Schlagwort(e): Microcorrosion casts ; Spiral lamina and limbus vessels ; Scanning electron microscopy ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A scanning electron microscope (SEM) study of corrosion cast preparations of the vessels of the spiral lamina and the spiral limbus was carried out in adult rats. This method confirms present knowledge of the modiolar vascularization and also shows its distribution in a three-dimensional model. As a result of this technique we have been able to demonstrate the modiolar vascular supply of the organ of Corti at different levels.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00457902
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  • 13
    Digitale Medien
    Digitale Medien
    A cochlear vascular anomaly in a patient with hearing loss and tinnitus (1981)
    Springer
    European archives of oto-rhino-laryngology and head & neck 233 (1981), S. 117-125 
    Details
    ISSN: 1434-4726
    Schlagwort(e): Aberrierendes Blutgefäß ; Scala tympani ; Mensch ; Haarzellverlust ; 2000 Hz-Senke ; Tinnitus ; Aberrant blood vessel (suspension vessel) ; Scala tympani ; Human ; Hair-cell loss ; 2,000 Hz dip ; Tinnitus
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Summary An unusual blood vessel in the cochlea of a patient is reported. The blood vessel derives from the osseous lamina spiralis and crosses straight through the scala tympani toward the lateral wall of the perilymphatic duct. In its course a branch derives from this vessel toward the other spiral vessel. In the region of this aberrant vessel a complete hair-cell loss is present. A high tone perceptive loss with a relative dip and tinnitus was found in the same ear during life. The possible cause and effects of this aberrant vessel are discussed.
    Notizen: Zusammenfassung Bericht über einen ungewöhnlichen Verlauf eines Blutgefäßes in der Cochlea eines Patienten. Das Gefäß zog von der Lamina spiralis ossea unter Durchquerung der Scala tympani bis zur lateralen Wand des Ductus perilymphaticus. In der Region dieses abnorm verlaufenden Gefäßes fand sich ein völliger Haarzellverlust. Beim Patienten bestand während des Lebens ein Hörverlust vor allem bei 2000 Hz mit Ohrensausen.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00453635
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  • 14
    Digitale Medien
    Digitale Medien
    Analysis of hearing loss due to cis-diamminedichloroplatinum-II (1984)
    Springer
    European archives of oto-rhino-laryngology and head & neck 239 (1984), S. 255-262 
    Details
    ISSN: 1434-4726
    Schlagwort(e): cis-Diamminedichloroplatinum-II ; Ototoxicity ; Incidence ; Dose-effect relatonship
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The difference in the hearing threshold before and after treatment with cis-diaminnedichloroplatinum (DDP) is analysed in 69 patients. Hearing loss due to DDP treatment is mainly limited to 8,000 Hz and the incidence is about 40%. The effect of DDP is dose-related, although even at the lowest dose 20% of the patients are affected. The age of the patients is not an important factor. Loss of hearing due to DDP treatment occurs independent of any pre-existent hearing loss although those patients with great pre-existent hearing loss do not show a further loss. Of the patients with hearing loss, 39% show a difference of 20 dB or more between the left and the right ear. Hearing loss due to DDP is of minor importance compared with many of the other side-effects of DDP.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00464252
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  • 15
    Digitale Medien
    Digitale Medien
    Otorhinolaryngological findings in AIDS patients: a study of 63 cases (1987)
    Springer
    European archives of oto-rhino-laryngology and head & neck 244 (1987), S. 11-14 
    Details
    ISSN: 1434-4726
    Schlagwort(e): Acquired immunodeficiency syndrome (AIDS) ; ORL symptoms ; Candidiasis ; Kaposi's sarcoma
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Patients with acquired immunodeficiency syndrome (AIDS) frequently show signs and symptoms involving the head and neck. We reviewed the clinical histories of 63 cases with AIDS, with patients treated from 1982 to December 1985, in our hospital. Findings referable to the head and neck were seen in 43 patients. Comparison with a previous study in San Francisco revealed remarkable differences. We found otolaryngological manifestations in 68% of the patients in contrast to 41% in this latter study. We saw more rapidly increasing neck masses, a greater incidence of shortness of breath and chronic cough, and an increased occurrence of candidiasis. The number of cases with Kaposi's sarcoma lesions was equal in both studies.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00453483
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  • 16
    Digitale Medien
    Digitale Medien
    Pathological findings in the human auditory system following long-standing gentamicin ototoxicity (1987)
    Springer
    European archives of oto-rhino-laryngology and head & neck 244 (1987), S. 69-73 
    Details
    ISSN: 1434-4726
    Schlagwort(e): Gentamicin ototoxicity ; Human inner ear ; Microdissection ; Surface preparation technique
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The clinical, audiovestibular and histopathological findings in a patient who suffered from a long-standing gentamicin-induced deafness are reported. In both temporal bones, the organ of Corti was completely absent, with only a few nerve fibres remaining in the apical part of the cochlea. Regenerative ingrowth of nerve fibers into the area of the degenerative organ of Corti was present apically in both ears. The stria vascularis exhibited considerable degeneration in all turns and loss of microvasculature was found in the basilar membrane. The spiral ganglion cells, the cochlear nerve and the central auditory pathways and nuclei appeared to be unaffected.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00458549
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  • 17
    Digitale Medien
    Digitale Medien
    Repair of the ossicular chain with an ionomer cement by an inadequate incus after prior stapes surgery for otosclerosis (1996)
    Springer
    European archives of oto-rhino-laryngology and head & neck 253 (1996), S. 313-315 
    Details
    ISSN: 1434-4726
    Schlagwort(e): Conductive hearing loss ; Otosclerosis Stapedectomy ; Ossicular discontinuity ; Bone cement
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Use of an ionomer bone cement is described for repairing the ossicular middle ear system in revision stapes surgery. The cement was used to enlarge an eroded inadequate incus to allow placement of a new stapes prosthesis. Reconstruction of the incus with this new bone cement was readily performed and hearing results after 2 years of follow-up have been promising.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00171151
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