ISSN:
1438-2199
Keywords:
Amino acids
;
Glucose-cysteine adduct
;
Cysteine prodrug
;
Liver perfusion
;
Glutathione
;
Diethyl maleate
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Insitu perfusion of rat liver was performed with a medium containing glucose-cysteine adduct [2-(D-gluco-pentahydroxypentyl) thiazolidine-4-carboxylic acid, glc-cys] and its effect on glutathione (GSH) and ATP levels and bile production was examined. The GSH content in the liver was maintained at the original level during perfusion with 1 mM glc-cys for 2h, while it decreased significantly in the absence of glc-cys. After 4h of perfusion without glc-cys, ATP content and bile production decreased significantly besides the decrease in GSH content, but they were maintained at the original levels with glc-cys. When the perfusion was performed with the liver of rats injected with diethyl maleate (DEM), the GSH level, which was decreased to 6.0% of the control by DEM injection, was restored to 22.6% of the original level by perfusion with 2mM glc-cys for 30 min. Data indicate that glccys is a cysteine prodrug with protective action on the liver.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01373424
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