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  • 1
    Electronic Resource
    Electronic Resource
    Classical and quantum magnetism in synthetic ferritin proteins : The 40th annual conference on magnetism and magnetic materials (1996)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 79 (1996), S. 5324-5326 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The magnetic properties of nanometer-scale particles are studied using the protein-complex ferritin as a vesicle for either an antiferromagnet or a ferrimagnet. For antiferromagnetic ferritin particles, the anisotropy energy is found to depend linearly on the particle volume, suggesting that bulk anisotropy dominates over surface anisotropy. Effects due to the bulk and surface spins are discerned at high magnetic fields (27 T). At very low magnetic fields (1 nT) and temperatures (20 mK), the tunneling frequency of the Néel vector is observed to scale exponentially with the particle volume, consistent with the linear dependence of the anisotropy barrier on volume and with theories of macroscopic quantum coherence. In the ferrimagnetic particles, the anisotropy barrier decreases for smaller particles while simultaneously displaying a slight increase in coercivity and a dramatic decrease in the remanence over three orders of magnitude. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.361366
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  • 2
    Electronic Resource
    Electronic Resource
    II. COLLECTION AND PRESERVATION OF MATERIAL.1 (1909)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 31 (1909), S. 1335-1341 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01942a013
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  • 3
    Electronic Resource
    Electronic Resource
    Synthesis of acetyl-CoA and acetyl-dephospho-CoA by acetyl-CoA synthetase in the rat (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 30 (1978), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1978.tb10803.x
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  • 4
    Electronic Resource
    Electronic Resource
    THE SYNTHESIS OF ACETYLCHOLINE FROM ACETYL-CoA, ACETYL-DEPHOSPHO-CoA AND ACETYLPANTETHEINE PHOSPHATE BY CHOLINE ACETYLTRANSFERASE (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 29 (1977), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— The synthesis of ACh by choline acetyltransferase (ChAc) has been examined using acetyl-CoA, acetyl-dephospho-CoA and acetylpantetheine phosphate. At pH 7.5 Km values of 25.7 μm for acetyl-CoA, 54.8 μm for acetyl-dephospho-CoA and 382 μm for acetylpantetheine phosphate were obtained and are similar to those at pH 6.0. This indicates that the 3-phosphate may not be required for binding the substrate to the enzyme unlike carnitine acetyltransferase.Inhibitor constants (Ki) for CoA, dephospho-CoA and pantetheine phosphate were also measured and when considered with the Km values obtained for the acetyl derivatives it is concluded that acetyl-dephospho-CoA could be a successful acetyl donor in the synthesis of ACh.Acetyl-dephospho-CoA was found to be less satisfactory as a substrate for citrate synthase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1977.tb10691.x
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  • 5
    Electronic Resource
    Electronic Resource
    Free choline in the brain of the rat (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 28 (1977), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1977.tb07735.x
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  • 6
    Electronic Resource
    Electronic Resource
    TRANSPORT OF CHOLINE ACETYLTRANSFERASE AND ACETYLCHOLINESTERASE IN THE RAT SCIATIC NERVE: A BIOCHEMICAL AND ELECTRON HISTOCHEMICAL STUDY (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 21 (1973), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The transport of acetylcholinesterase (AChE) and choline acetyltransferase (ChAc) were investigated by biochemical and histochemical methods. After ligature of one of the sciatic nerves of the rat for varying times—4, 14, 20 and 44 h—the normal levels and the accumulation of AChE and ChAc activities were investigated. It can be inferred from the results that there is a rapid accumulation of AChE activity just proximal to the ligature, while the increase in ChAc activity is less pronounced. Distal to the ligature the level of AChE is above the control value whereas, in contrast to this, the ChAc activity is significantly decreased. Histochemical demonstration of the two enzymes indicates that they are present in the cholinergic axons. The reaction end-product produced by AChE occurs within vesicles and neurotubules, while the endproduct due to ChAc appears to be free in the axoplasm, bound to neurofilaments and on the outer surface of vesicles and tubules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1973.tb04262.x
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  • 7
    Electronic Resource
    Electronic Resource
    Free choline levels in the rat brain (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 20 (1973), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Choline levels in nervous tissue have been investigated by a number of workers in recent years. The values have varied widely from 39.3 nmol/g (Ewetz, Sparf and Söbo, 1970) to 700 nmol/g (Smith and Saelens, 1967). Many of the values published may have been too high for one of the following reasons: (1) post mortem formation of choline, (2) hydrolysis of phospholipids (PL) by extractants and (3) inadequate assay systems. In the past we too have obtained values which we can now with confidence say were too high due to the post mortem formation of choline. In a method which employed bioassay as an end-step after extraction of choline by acid-ethanol the values we obtained were 138 ±27 nmol/g. Despite criticism of this method by Ewetzet al. (1970) and Schuberth, Sparf and Sundwall (1970a) we were reasonably sure that the assay system was both sensitive and specific, and that extraction with acid-ethanol did not lead to liberation of choline from PL, especially since values for plasma choline by this method were in a number of trial extractions as low as 8 nmol/ml. In view of these results we decided to re-investigate free choline levels in the brain using a method similar to that of Ewetzet al. (1970) in that the living animal (in this case anaesthetized) was frozen in liquid nitrogen before removing the brain, and comparing the results of three different methods of analysis applied to brain extracts prepared in this way.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1973.tb00266.x
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  • 8
    Electronic Resource
    Electronic Resource
    INHIBITION OF GUINEA-PIG BRAIN TYROSINE HYDROXYLASE BY CATECHOLS AND BIOPTERIN (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 33 (1979), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: —The inhibition by catechols and biopterin of tyrosine hydroxylase from guineapig caudate nuclei has been examined. Inhibitory constants of 10–20 μm were obtained for dopamine and noradrena-line and 150–250 μmfor l-DOPA and dihydroxyphenylacetic acid. When examined under similar conditions homovanillic acid was found not to be inhibitory. Using an acetone dried powder as the source of tyrosine hydroxylase no change in Km or Vmax was observed when cyclic AMP or Ca2+ were added to the medium. Enzyme mechanisms and a possible explanation of the mechanisms controlling catechol synthesis are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1979.tb11715.x
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  • 9
    Electronic Resource
    Electronic Resource
    Comparison of 40 mg famotidine nightly and 150 mg ranitidine b.d.: ulcer healing and symptom relief in benign gastric ulcer (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 3 (1989), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Two hundred and eight patients with benign gastric ulcers seen on endoscopy were recruited by 13 hospitals in the United Kingdom and Ireland into this double-blind study. Patients were assigned by prerandomized schedule to 8 weeks of treatment with either 40 mg famotidine at night or 150 mg ranitidine b.d. Repeat endoscopy confirmed complete ulcer healing in 62 of 77 evaluable patients in the famotidine group (81%) and 58 of 71 in the ranitidine group (82%). The treatments were equally effective in promptly relieving day and night pain. Adverse events were uncommon; dizziness and headaches were the most frequently reported in both groups. In conclusion, night-time famotidine is as effective as twice daily ranitidine in healing benign gastric ulcers and provides similarly rapid symptomatic relief.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.1989.tb00237.x
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  • 10
    Electronic Resource
    Electronic Resource
    Nocturnal intragastric acidity after over-the-counter doses of famotidine, ranitidine or placebo (1997)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 11 (1997), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To compare the inhibitory effects of over-the-counter doses of famotidine or ranitidine on nocturnal intragastric acidity in a placebo-controlled study.〈section xml:id="abs1-2"〉〈title type="main"〉Methods:Twelve-hour intragastric acidity was measured simultaneously in 24 healthy subjects who ate a standard meal at 18.30 h and were dosed (at 19.30 h) with either famotidine 10 mg, ranitidine 75 mg or placebo in a balanced three-period crossover design. Five-millilitre aliquots of gastric juice were aspirated half-hourly 0–3 h post-dose, and then hourly until the end of the study. pH was measured with a glass electrode. Integrated pH (area under the curve (AUC) of the pH–time curve) was calculated for the intervals 0–12 h and 9–12 h post-dose. Statistical analysis was by ANOVA.〈section xml:id="abs1-3"〉〈title type="main"〉Results:In the 0–12 h post-dose period, when the 24 subjects were dosed with placebo, mean AUC was 2.12, dosed increasing by 75% to 3.70 with famotidine (P 〈 0.001) and by 81% to 3.83 with ranitidine (P 〈 0.001). In the 9–12 h post-dose period, when the subjects were dosed with placebo, mean AUC was 2.13 increasing by 91% to 4.07 with famotidine (P 〈 0.001) and by 79% to 3.82 with ranitidine (P 〈 0.001). There was no significant difference between the pH-raising effects of famotidine and ranitidine in both periods.〈section xml:id="abs1-4"〉〈title type="main"〉Conclusions:Famotidine and ranitidine in over-the-counter doses have a similar, sustained, effect on post-prandial nocturnal intragastric acidity in healthy subjects lasting up to 12 h after oral dosing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.1997.00211.x
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