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  • 1
    Digitale Medien
    Digitale Medien
    Unusual Forms of Insulin Resistance (1991)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Medicine 42 (1991), S. 373-379 
    Details
    ISSN: 0066-4219
    Quelle: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1146/annurev.me.42.020191.002105
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  • 2
    Digitale Medien
    Digitale Medien
    Ependymomas of the posterior cranial fossa: CT and MRI findings (1995)
    Springer
    Neuroradiology 37 (1995), S. 238-243 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Key words Ependymoma ; Posterior cranial fossa ; Children ; Magnetic resonance imaging ; Computed tomography ; Brain tumours
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We studied nine children with posterior cranial fossa ependymomas to identify specific neuroradiological features. Patients were studied preoperatively with CT and MRI; T1-, T2- and proton-density (PD)-weighted images were obtained. All children underwent surgery and a definite histopathological diagnosis was made. All the tumours grew into the fourth ventricle and caused dilatation of its upper part, which resembled a cap. All but one were separated from the vermis by a cleavage plane. In eight cases there was desmoplastic development through the foramina of the fourth ventricle, and five were heterogeneous due to necrosis and cystic change; one had a haemorrhagic area. In most cases the solid portion was isointense with grey matter on T1-weighted images, hyperintense on PD weighting, and isointense on T2-weighted images. On CT the tumour was isodense in six cases and calcification was detected in four. The presence of both desmoplastic development and a tumour/vermis cleavage plane in a posterior cranial fossa tumour isodense on CT is highly suggestive of ependymoma.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01578265
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  • 3
    Digitale Medien
    Digitale Medien
    Ependymomas of the posterior cranial fossa: CT and MRI findings (1995)
    Springer
    Neuroradiology 37 (1995), S. 238-243 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Ependymoma ; Posterior cranial fossa ; Children ; Magnetic resonance imaging ; Computed tomography ; Brain tumours
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We studied nine children with posterior cranial fossa ependymomas to identify specific neuroradiological features. Patients were studied preoperatively with CT and MRI; T1-, T2-and proton-density (PD)-weighted images were obtained. All children underwent surgery and a definite histopathological diagnosis was made. All the tumours grew into the fourth ventricle and caused dilatation of its upper part, which resembled a cap. All but one were separated from the vermis by a cleavage plane. In eight cases there was desmoplastic development through the foramina of the fourth ventricle, and five were heterogeneous due to necrosis and cystic change; one had a haemorrhagic area. In most cases the solid portion was isointense with grey matter on T1-weighted images, hyperintense on PD weighting, and isointense on T2-weighted images. On CT the tumour was isodense in six cases and calcification was detected in four. The presence of both desmoplastic development and a tumour/vermis cleavage plane in a posterior cranial fossa tumour isodense on CT is highly suggestive of ependymoma.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01578265
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  • 4
    Digitale Medien
    Digitale Medien
    Spinal dysraphism: a review of neuroradiological features with embryological correlations and proposal for a new classification (2000)
    Springer
    Neuroradiology 42 (2000), S. 471-491 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Key words Spine ; dysraphism ; Spinal cord ; tethered ; Spina bifida magnetic resonance imaging
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Our purpose was to review the neuroradiological features of spinal dysraphism and to correlate them with clinical findings and up-to-date embryological theory. We also aimed to formulate a working classification which might prove useful in clinical practice. We reviewed series of 986 children referred to our Spina Bifida Centre in the past 24 years. There were 353 children with open spinal (OSD) and 633 with closed (skin-covered) spinal (CSD) dysraphism. By far the most common open abnormality was myelomeningocele, and all patients with OSD had a Chiari II malformation. CSD was categorised clinically, depending on the presence of a subcutaneous mass in the back. CSD with a mass mainly consisted of lipomas with dural defects and meningoceles, and accounted for 18.8 % of CSD. CSD without a mass were simple (tight filum terminale, intradural lipoma) or complex (split cord malformations, caudal regression). Our suggested classification is easy to use and to remember and takes into account clinical and MRI features; we have found it useful and reliable when making a preoperative neuroradiological diagnosis in clinical practice.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002340000325
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  • 5
    Digitale Medien
    Digitale Medien
    Occult spinal dysraphism: neuroradiological study (1990)
    Springer
    Neuroradiology 31 (1990), S. 512-522 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Occult spinal dysraphism ; Lipoma ; Tethered cord ; Spinal cord ; Caudal regression syndrome ; Developmental mass lesions
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We present a retrospective study of occult spinal dysraphism in 47 children aged 0 to 14 years, all studied with plain X-rays, 60% with CT and myelo-CT, and 40% with MR. We consider the classification and grading of these malformations, clinical, neuroradiological patterns, and indications for surgery. In the light of our findings and of the published data MR emerges as the key investigation. Only in a few cases of great anatomical complexity is it now necessary to perform CT and myelo-CT as well. A case in point is when the conus and thickened filum terminale are inextricably bound together and can no longer be considered separate structures. We propose the term “neurofibrous structure” to define the conus-thickened-filum-terminale unit when these structure are no longer distinguishable.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00340133
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  • 6
    Digitale Medien
    Digitale Medien
    Medulloblastoma in children: CT and MRI findings (1996)
    Springer
    Neuroradiology 38 (1996), S. 352-359 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Key words Medulloblastoma ; Childhood brain tumours ; Magnetic resonance imaging ; Computed tomography
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Our purpose was to determine whether medulloblastoma (MB) shows specific neuroradiological features which may be employed in differential diagnosis from other common posterior cranial fossa tumours in childhood. Preoperative MRI was performed on 20 children with MB, and preoperative CT in 17 of them. All underwent surgery and histopathological diagnosis. There was a constant relationship between high density on CT and low signal on T1-weighted images. Signal behaviour on T2-weighted images and the degree of contrast enhancement were more variable. Most tumours arose in the midline, from the cerebellar vermis, involving the fourth ventricle, but hemisphere and extra-axial neoplasms were also seen. The combination of high density on CT and low signal on T1-weighted images is highly suggestive of MB and may assist preoperative differential diagnosis from other posterior cranial fossa tumours.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00596587
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  • 7
    Digitale Medien
    Digitale Medien
    Medulloblastoma in children: CT and MRI findings (1996)
    Springer
    Neuroradiology 38 (1996), S. 352-359 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Medulloblastoma ; Childhood brain tumours ; Magnetic resonance imaging ; Computed tomography
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Our purpose was to determine whether medulloblastoma (MB) shows specific neuroradiological features which may be employed in differential diagnosis from other common posterior cranial fossa tumours in childhood. Preoperative MRI was performed on 20 children with MB, and preoperative CT in 17 of them. All underwent surgery and histopathological diagnosis. There was a constant relationship between high density on CT and low signal on T1-weighted images. Signal behaviour on T2-weighted images and the degree of contrast enhancement were more variable. Most tumours arose in the midline, from the cerebellar vermis, involving the fourth ventricle, but hemisphere and extra-axial neoplasms were also seen. The combination of high density on CT and low signal on T1-weighted images is highly suggestive of MB and may assist preoperative differential diagnosis from other posterior cranial fossa tumours.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00596587
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  • 8
    Digitale Medien
    Digitale Medien
    Use of acrylic prosthesis in cervical spine pathology (1984)
    Springer
    Acta neurochirurgica 71 (1984), S. 141-149 
    Details
    ISSN: 0942-0940
    Schlagwort(e): Cervical spine ; acrylic prosthesis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The authors report on their experience with the use of a reinforced acrylic prosthesis in cervical spine pathology. The study of their own 45 cases enables the advantages and disadvantages of the technique to be demonstrated. A discussion of possible improvements in the technique and its indication completes the report.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01401159
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  • 9
    Digitale Medien
    Digitale Medien
    Tyrosine kinase activity of insulin receptors from an insulin-resistant patient with leprechaunism (1987)
    Springer
    Diabetologia 30 (1987), S. 631-637 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Insulin receptor ; tyrosine kinase ; insulin resistance ; anti-receptor antibodies ; leprechaunism
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Defects in insulin receptor function can impair the response of target cells to insulin. Previously we have described an insulin resistant patient (leprechaun/Ark−1) with qualitative abnormalities in insulin binding suggestive of a structural defect in her insulin receptors. In the present work, we have studied the tyrosine kinase activity associated with insulin receptors from cultured Epstein-Barr virus-transformed lymphocytes. In studies of insulin receptors from leprechaun/Ark−1, we observed that both the magnitude and the dose-dependency of insulin's effect to stimulate the tyrosine kinase activity were normal. This suggests that the defect causing this patient's insulin resistance is independent of the receptor-associated tyrosine kinase. In the course of these studies, we noted that an anti-receptor antiserum (B−d) had a markedly decreased ability to immunoprecipitate insulin receptors from leprechaun/Ark−1. This observation further supports our previous conclusion that the insulin receptor from leprechaun/Ark−1 is abnormal in structure. Moreover, it emphasizes the importance of choosing anti-receptor antisera which are equally effective at immunoprecipitating receptors from both patients and normal subjects when the anti-receptor antisera are employed as reagents in investigations of receptors from insulin-resistant patients.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00277320
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  • 10
    Digitale Medien
    Digitale Medien
    Percutaneous interbody osteosynthesis in the treatment of thoracolumbar traumatic or tumoural lesions (1990)
    Springer
    Acta neurochirurgica 102 (1990), S. 42-53 
    Details
    ISSN: 0942-0940
    Schlagwort(e): Lumbordorsal spine ; interbody osteosynthesis ; percutaneous
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The authors describe a technique of percutaneous interbody osteosynthesis applicable to the dorsal and lumbar spine. 51 patients were so treated for different aetiologies:traumatic conditions (35 cases) andtumoural lesions (16 cases). The material used consisted of special instruments that are positioned in double obliquity by a percutaneous posterolateral approach. A posterior approach limited to the pathological focus was used jointly whenever a graft or a decompression was necessary (19 cases). Several types of anaesthesia were used (local, local-regional, general, neuroleptanalgesia). The patients benefited by the advantages that usually accompany percutaneous techniques. The advantages and limitations of the method are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01402185
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