ISSN:
1572-901X
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
Notizen:
Abstract Five complexes of transition metals with all-trans retinoic acid (HRA) have been prepared and characterized by elemental analysis, molar conductance, t.g.–d.t.a, i.r., and u.v.-vis. spectroscopy, and 1H-n.m.r. spectrometry. The general formula of these complexes is ML2 ·nH2O where L=RA, M=MnII, CoII, NiII, CuII, ZnII, and n=3 or 4. They have been studied for their antitumour activity against human bladder cancer line EJ (EJ cells) with respect to proliferation, induce differentiation, P21 and mutation P53 expressions in vitro.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1023/A:1006937915080
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