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  • 1
    Digitale Medien
    Digitale Medien
    Femtosecond-laser-induced spallation in aluminum (2001)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 89 (2001), S. 3520-3522 
    Details
    ISSN: 1089-7550
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: Ultrashort laser pulses having 50 fs duration were used to cause planer fracture, i.e., spallation, in pure aluminum foils at intensities of (0.07–1)×1015 W/cm2. A linear relationship was obtained between spall depth and foil thickness, approximately corresponding to the proportions that were obtained in other relations for 300 ps and longer laser pulse irradiation. Spall thicknesses less than 5 μm were obtained in foils thinner than 50 μm, and revealed small-scale spallation at a strain rate exceeding 108 s−1. This ultrashort laser pulse evidently produced a shock wave followed by a steep unloading stress profile. © 2001 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.1346996
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  • 2
    Digitale Medien
    Digitale Medien
    Thyroid Hormones Regulate Pituitary Growth Hormone Secretagogue Receptor Gene Expression (2001)
    Oxford, UK : Blackwell Science, Ltd
    Journal of neuroendocrinology 13 (2001), S. 0 
    Details
    ISSN: 1365-2826
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Thyroid hormones regulate growth hormone (GH) secretion by actions both at the hypothalamus and at the pituitary gland. At the level of the pituitary, thyroid hormones increase GH and GH-releasing hormone receptor (GHRH-R) mRNA expression. To test if thyroid hormones might also regulate the pituitary expression of mRNA for the recently identified GH secretagogue (GHS) receptor, GHS-R, primary pituitary cell cultures from adult male rats were treated with triiodothyronine (T3) and GHS-R mRNA levels were assessed by reverse transcriptase-polymerase chain reaction. T3 increased pituitary GHS-R mRNA levels in a dose- and time-dependent manner. The stimulatory action of T3 on GHS-R mRNA levels was also observed in the presence of the RNA synthesis inhibitor, actinomycin D, indicating that gene transcription is not required. Closer examination of the decay rates of GHS-R mRNA in the presence of actinomycin D revealed T3 extended the half-life of the GHS-R mRNA from 8 h (basal) to15 h, demonstrating that T3 increases GHS-R mRNA levels in vitro by increasing message stability.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2826.2001.00623.x
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  • 3
    Digitale Medien
    Digitale Medien
    Glucocorticoids Regulate Pituitary Growth Hormone Secretagogue Receptor Gene Expression (2000)
    Oxford, UK : Blackwell Science Ltd
    Journal of neuroendocrinology 12 (2000), S. 0 
    Details
    ISSN: 1365-2826
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Glucocorticoids regulate growth hormone (GH) secretion by modulating both hypothalamic and pituitary function. At the level of the pituitary, glucocorticoids increase GH and GH-releasing hormone receptor (GHRH-R) gene expression. To test if glucocorticoids might also regulate the pituitary expression of the recently identified GH secretagogue (GHS) receptor, GHS-R; adult male rats were adrenalectomized or sham operated, and treated with the synthetic glucocorticoid (dexamethasone, 200 µg/day) or vehicle for 8 days. Pituitary GHS-R mRNA levels were assessed by reverse transcriptase polymerase chain reaction (RT-PCR). Adrenalectomy decreased pituitary GHS-R mRNA to 45% of vehicle-treated, sham-operated rats (P 〈 0.05). Administration of dexamethasone increased GHS-R mRNA levels in sham-operated as well as in adrenalectomized rats (199 ± 24% (P 〈 0.05) and 369 ± 48% (P 〈 0.01) of vehicle-treated controls). Addition of dexamethasone to primary rat pituitary cell cultures increased GHS-R mRNA levels in a dose- and time-dependent manner while the transcriptional inhibitor, actinomycin D, completely blocked the stimulatory action of dexamethasone. Taken together, these results suggest glucocorticoids directly increase pituitary GHS-R mRNA levels by stimulating GHS-R gene transcription.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2826.2000.00446.x
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  • 4
    Digitale Medien
    Digitale Medien
    Polarization behaviour and lifetime of IrO2–Ta2O5–SnO2/Ti anodes in p-phenolsulfonic acid solutions for tin plating (2000)
    Springer
    Journal of applied electrochemistry 30 (2000), S. 511-514 
    Details
    ISSN: 1572-8838
    Schlagwort(e): durability improvement ; electrotinning line ; IrO2–Ta2O5–SnO2/Ti anodes ; p-phenolsulfonic acid bath
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Elektrotechnik, Elektronik, Nachrichtentechnik
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1003977928651
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  • 5
    Digitale Medien
    Digitale Medien
    A case of chronic myeloid leukemia with minor bcr-abl transcript following fluorouracil therapy for esophageal carcinoma (2000)
    Springer
    Annals of hematology 79 (2000), S. 396-401 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Key words CML ; Minor bcr-abl ; Therapy-related leukemia ; Fluorouracil
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We report here a very rare case of chronic myeloid leukemia (CML) with a minor bcr-abl transcript, which developed following long-term chemotherapy with fluorouracil for esophageal carcinoma. A 64-year-old male patient was diagnosed with CML. Four years earlier, he had suffered from esophageal carcinoma, which was treated by surgical resection followed by oral administration of fluorouracil (200 mg/day) for 4 years. Molecular analysis of his Philadelphia chromosome (Ph) using reverse-transcriptase polymerase chain reaction (RT-PCR) and subsequent sequencing revealed a minor bcr-abl transcript. The clinical course of this patient was aggressive with a short chronic phase of CML. This is the first reported case of secondary CML with a minor bcr-abl transcript.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002779900151
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  • 6
    Digitale Medien
    Digitale Medien
    Investigation of hydrocephalus with three-dimensional constructive interference in steady state MRI (2000)
    Springer
    Neuroradiology 42 (2000), S. 634-638 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Key words Hydrocephalus ; Magnetic resonance imaging, pulse sequences ; Neurosurgery, endoscopic
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We report four patients with various types of hydrocephalus in whom constructive interference in steady state (CISS) MRI disclosed the cause of the hydrocephalus. The imaging clearly delineated an abnormal contour of the ventricular system and intraventricular septa, essential information for surgical planning, including endoscopic surgery. Postoperative CISS images were useful for showing not only regression of hydrocephalus but also the patency of small fenestrations.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002340000330
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