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  • 1
    Electronic Resource
    Electronic Resource
    Ion diffusion in a velocity space induced by Alfvén ion cyclotron mode observed in a mirror plasma (2000)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 7 (2000), S. 2485-2493 
    Details
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Ion distributions in a loss cone are measured in the GAMMA 10 tandem mirror [Phys. Rev. Lett. 55, 939 (1985)]. When Alfvén ion cyclotron (AIC) modes are excited in the central cell, enhanced end-loss of ions is observed for a characteristic energy region which agrees well with the resonant ion cyclotron condition with the AIC wave. From measurements of pitch angle distributions of end-loss ions, it is found that the loss cone is filled for this characteristic energy region, indicating an ion diffusion in a velocity space induced by the AIC wave. Magnitude of the observed additional end-loss increases with increase in the amplitude of the AIC modes. In the present experimental parameters in GAMMA 10, the AIC wave effect on the axial ion confinement is not serious. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.874088
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  • 2
    Electronic Resource
    Electronic Resource
    Suppression of a pressure driven m=1 mode in a lower hybrid current drive plasma by electron cyclotron heating in the WT-3 tokamak (2000)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 7 (2000), S. 276-282 
    Details
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A pressure driven m=1/n=1 mode is excited by lower hybrid current drive in the WT-3 tokamak [T. Maehara et al., Nucl. Fusion 38, 39 (1998)]. The excitation of the mode is accompanied with the decrease of the magnetic shear and with the peaking of the soft x-ray emissivity profile inside the q=1 surface. The crescent-shaped mode structure appeared on the contour map of the soft x-ray emissivity is consistent with that of the quasi-interchange mode. The m=1 mode can be suppressed by electron cyclotron heating near the q=1 surface. The range of the location of the electron cyclotron resonance layer effective for the complete suppression is much wider and the time scale for the suppression is much faster than those in the case of the suppression of the tearing mode in the ohmic heating plasma. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.873823
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  • 3
    Electronic Resource
    Electronic Resource
    High precision polarimeter system for atomic polarization and tilted-foil experiments with 1.7 keV/amu 14N+ beam (2000)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 71 (2000), S. 2045-2049 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A high precision atomic polarimeter system for the use in beam-foil spectroscopy experiments with a few keV/amu heavy-ion beams has been developed. The polarimeter measures the circular polarization of fluorescences from the beam ion in-flight after the beam–foil interaction. The present system has two identical such polarimeters in both sides of the beam axis to reduce the systematic errors such due to the fluctuations of beam current, background and so on. A successful use of an ultrathin carbon foil (1.5 μg/cm2), which was durable for several hours against a few hundred nA beam irradiation, enabled the beam–foil experiments with such low energy heavy-ion beams. A performance test of the polarimeter system was carried out in the tilted foil experiments with a 1.7 keV/amu 14N+ beam. The atomic polarization was observed for the transition 1s22s22p3p 1D→1s22s22p3p 1P, whose fluorescence wavelength is 399.5 nm, in the N+ ion (N II). The polarization was approximately −2% for the tilt angle of −40° and showed monotone increasing with increasing tilt angle up to +2% for +40°. The polarization at 0° was (0.002±0.25)%, which is highly consistent with the expected polarization of 0%. This result indicates the high reliability of the present polarimeter system. This is the first tilted-foil experiment at such low beam energy. The present experimental technique will be very useful for studies of the polarization mechanism of the beam–foil interaction. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1150576
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  • 4
    Electronic Resource
    Electronic Resource
    Sebaceous glands in acne patients express high levels of neutral endopeptidase (2002)
    Copenhagen : Munksgaard International Publishers
    Experimental dermatology 11 (2002), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Acne is a complex, chronic and common skin disorder of pilosebaceous units. Although it is known that exacerbation of acne results from emotional stress, the nature of the association between stress and acne remains unclear. This is due in part to the lack of substantial evidence regarding the participation of cutaneous neurogenic factors in the pathogenesis of acne. To examine the possible involvement of neurogenic factors in the etiology of acne, we used immunohistochemistry to compare the distribution of SP-containing nerve fibers around sebaceous glands and the expression of neutral endopeptidase in sebaceous acini of the facial skin of acne patients and of healthy subjects. More numerous substance P immunoreactive nerve fibers in close apposition to the sebaceous glands and an increase in expression of neutral endopeptidase in sebaceous acini were observed in acne patients compared with the controls. Immunoelectron microscopy revealed that the subcellular localization of neutral endopeptidase was restricted to the Golgi apparatus and the endoplasmic reticulum within sebaceous germinative cells. In addition, in vitro experiments using an organ culture system demonstrated that substance P induced expression of neutral endopeptidase in sebaceous glands in a dose dependent manner. This study reveals that substance P and its degrading enzymes are involved in the pathogenesis of acne, which in turn might partially explain the pathologic significance of neurogenic and psychogenic aspects in the disease process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0625.2002.110307.x
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  • 5
    Electronic Resource
    Electronic Resource
    Axial profile measurement of Alfvén ion cyclotron eigenmodes : Papers from the thirteenth topical conference on high temperature plasma diagnostics (2001)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 72 (2001), S. 394-397 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: In the GAMMA10 tandem mirror, a strong ion cyclotron range of frequency heating is performed. As a result of the heating, the Alfvén ion cyclotron (AIC) modes are spontaneously excited due to the strong temperature anisotropy. The AIC modes in the GAMMA10 are excited as the axial eigenmodes and detected at the whole of the device. In the recent experiments, the clear standing wave structure is observed with the magnetic probe measurements. Characteristics of the AIC modes and the measurement of the axial profile are presented. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1309008
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  • 6
    Electronic Resource
    Electronic Resource
    Probe wave system for studying excitation of Alfvén eigenmodes in the ion cyclotron range of frequency : Papers from the thirteenth topical conference on high temperature plasma diagnostics (2001)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 72 (2001), S. 398-401 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A probe wave system was constructed for studying the excitation of the Alfvén ion cyclotron (AIC) modes in the anchor cell of the GAMMA 10 tandem mirror. In the central cell, the AIC modes are spontaneously excited as axial eigenmodes due to the strong temperature anisotropy. In the anchor cell, the AIC modes were not observed though the anisotropy is the same as in the central cell. The axial profiles of the magnetic field strength and plasma parameters in the anchor cell are different from those in the central cell. Eigenmodes are excited externally in the AIC frequency range by injecting probe waves. This suggests the AIC modes are unstable in the anchor cell and grow to the detectable level when boundary conditions are realized. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1315638
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  • 7
    Electronic Resource
    Electronic Resource
    Ocular Toxoplasmosis: More Than Just What Meets the Eye (2002)
    Oxford, UK : Blackwell Science Ltd
    Scandinavian journal of immunology 55 (2002), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Toxoplasma gondii is an intracellular parasite whose life cycle may include the man as an intermediate host. Close to a billion people are infected with this parasite worldwide. Ocular lesions may occur in up to 25% of those individuals infected. The infection may occur intra-uterus, through the placenta when the mother is infected during pregnancy. The parasite may also infect adults after the ingestion of contaminated food products, most notably meats or water. We have shown that although congenital and post-natal (acquired) infection results in similar ocular lesions, the immunological mechanisms behind the development of disease are different. On the other hand, contrary to published data obtained in mice, we were unable to find evidence that the T. gondii express superantigen activity for human lymphocytes. Our findings are important because they suggest that superantigen activity is not important as a pathological mechanism in human disease. Our data also suggest that, whereas the ocular lesion caused by infection after birth is the result of an excessive or dysfunctional immune response, the lesions caused by congenital infection may be due to a lack of an appropriate response to the parasite.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3083.2002.01052.x
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  • 8
    Electronic Resource
    Electronic Resource
    Localization and content of nerve growth factor in peripheral blood eosinophils of atopic dermatitis patients (2003)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 33 (2003), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Atopic dermatitis (AD) is a chronic and relapsing eczematous skin disorder characterized by eosinophilia. Nerve growth factor (NGF) modulates the allergic response through interactions with immune-inflammatory cells. Eosinophils have been reported to store NGF as a preformed mediator.Objective  To gain further insight into the significance of eosinophils in association with NGF in the pathogenesis of AD, the localization of NGF within eosinophils and the difference of the eosinophil-derived NGF content in the peripheral blood of normal volunteers vs. AD patients were investigated.Methods  We examined the localization of NGF within human eosinophils using the post-embedding immunoelectron microscopy and compared NGF content in freshly isolated eosinophil sonicates from the peripheral blood of 31 normal volunteers vs. 42 AD patients by immunoenzymatic assay. A possible correlation between the levels of NGF and major basic protein was also examined.Results  Immunoelectron microscopic studies revealed that NGF was localized in the central core of normal eosinophil granules, where major basic protein is also present as a preformed mediator, in homogeneous granules and in intergranular ductal or vesicular structures adjacent to specific granules of eosinophils. NGF content in eosinophils was significantly increased in AD patients. Furthermore, there was a significant correlation between levels of NGF and major basic protein in eosinophils of AD patients.Conclusions  Increased levels of NGF contained in eosinophils of the peripheral blood from AD patients, when released with other mediators such as basic proteins, could promote inflammation and local tissue damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2222.2003.01719.x
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  • 9
    Electronic Resource
    Electronic Resource
    Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: annotated tables (2001)
    Copenhagen : Munksgaard International Publishers
    Experimental dermatology 10 (2001), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Numerous transgenic, targeted mutagenesis (so-called knockouts), conditional (so-called “gene switch”) and spontaneous mutant mice develop abnormal hair phenotypes. The number of mice that exhibit such abnormalities is increasing exponentially as genetic engineering methods become routine. Since defined abnormalities in hair follicle morphogenesis, cycling and/or structure in such mutant mice provide important clues to the as yet poorly understood functional roles of many gene products, it is useful to summarize and classify these mutant mice according to their hair phenotype. This review provides a corresponding, annotated table of mutant mice with hair abnormalities, classifying the latter into 6 categories, 1) abnormally low number of hair follicles, 2) disorders of hair morphogenesis, 3) of hair follicle cycling, 4) of hair follicle structure 5) of sebaceous gland structure, and 6) hair growth disorders as a consequence of immunological abnormalities. This annotated table should serve as a useful source of reference for anyone who is interested in the molecular controls of hair growth, for investigators who are looking for mouse models to explore or compare the functional activities of their gene of interest, and for comparing the hair phenotype of newly generated mouse mutants with existing ones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0625.2001.100601.x
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  • 10
    Electronic Resource
    Electronic Resource
    Nerve growth factor and substance P are useful plasma markers of disease activity in atopic dermatitis (2002)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 147 (2002), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Background Neurogenic components, such as neurotrophic factors and neuropeptides, are probably involved in the pathogenesis of atopic dermatitis (AD) via the neuroimmunocutaneous system. Numerous in vitro and in vivo studies have shown that nerve growth factor (NGF), the best-characterized member of the neurotrophin family, modulates the synthesis of the neuropeptide substance P (SP), both of which may be associated with the pathogenesis of human allergic diseases. Objectives To evaluate the levels of NGF and SP in the plasma of patients with AD and to examine their possible correlation with disease activity. Methods We measured plasma levels of NGF by an immunoenzymatic assay and of SP by aradioimmunoassay in 52 patients with AD, and compared them with 35 normal non-atopic controls. The severity of the disease in AD patients was evaluated using validated clinical scoring systems. Results Patients with AD had significant increases in plasma levels of NGF and SP compared with controls (P 〈 0·0005 and P 〈 0·0001, respectively). A positive correlation between the plasma levels of NGF and SP was found in AD patients (correlation coefficient, Cc = 0·920, P 〈 0·0001). There was a significant correlation of plasma NGF and SP levels with disease activity evaluated using three different scoring systems: the grading system of Rajka and Langeland (P 〈 0·001 and P 〈 0·01, respectively), the objective Severity Scoring of AD (Cc = 0·656, P 〈 0·005 and Cc = 0·752, P 〈 0·0005, respectively) and the Eczema Area and Severity Index (Cc = 0·740, P 〈 0·001 and Cc = 0·765, P 〈 0·005, respectively). Conclusions These data represent the first reported evidence of increased plasma levels of NGF and SP in an allergic human skin disease. They suggest that these neurogenic factors systemically modulate the allergic response in AD, probably through interactions with cells of the immune-inflammatory component. In addition, NGF and SP may be useful markers of disease activity in patients with AD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2002.04803.x
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