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  • 1
    Digitale Medien
    Digitale Medien
    CERAMIDE-GALACTOSYLTRANSFERASE AND CEREBROSIDE-SULPHOTRANSFERASE LOCALISATION IN GOLGI MEMBRANES ISOLATED BY A CONTINUOUS SUCROSE GRADIENT OF MOUSE BRAIN MICROSOMES (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 33 (1979), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract— A 17,000 g supernatant of mouse brain microsomes was subfractionated on a continuous sucrose gradient in order to localise ceramide galactosyltransferase (CGalt, EC 2.4.1.47) and cerebroside sulphotransferase (CST, EC 2.8.2.11), both enzymes involved in the synthesis of myelin lipids. The submicrosomal fractions were analysed for marker enzymes of myelin, plasma membranes, Golgi membranes, endoplasmic reticulum and lysosomes, and their protein distribution was studied. The results and EM studies give evidence that CGalT and CST are located in the Golgi membranes of the brain.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1979.tb05180.x
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  • 2
    Digitale Medien
    Digitale Medien
    The ultrastructural localization of fibronectin in the lining layer of rheumatoid arthritis synovium: The synthesis of fibronectin by type B lining cells (1983)
    Springer
    Rheumatology international 3 (1983), S. 75-79 
    Details
    ISSN: 1437-160X
    Schlagwort(e): Synovial lining cells ; Type A cells ; Type B cells ; Fibronectin ; Rheumatoid arthritis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The distribution of fibronectin in the lining layer of inflamed rheumatoid arthritis (RA) synovium has been ultrastructurally investigated using an anti-human plasma fibronectin antibody. The hyperplasia of lining cells was prominent in the lining layer of the inflamed RA synovium. A high level of fibronectin was localized in this region. Ultrastructurally the fibronectin was observed on the surface of both type A (type M) and type B (type F) cells, and in the extracellular fibrin-like material. This glycoprotein was detectable in rough endoplasmic reticulum (RER), some Golgi apparatus, and peripheral vesicles of type B cells. On the other hand, RER and Golgi apparatus of type A cells failed to be immunostained with the antibody. Type A cells occasionally contacted each other with interdigitation of cytoplasmic processes, and a high amount of fibronectin was localized in this region. These findings indicate that fibronectin is synthesized along the classic secretory pathway through RER and Golgi apparatus of type B cells. On the contrary, type A cells seem not to be associated with the local synthesis of the glycoprotein. Fibronectin may play a structural role in organizing these proliferated lining cells by promoting cell adhesion. The synthesis of fibronectin by proliferated type B cells may be responsible in part for the local increase of this glycoprotein in the lining layer of RA synovium.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00541148
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  • 3
    Digitale Medien
    Digitale Medien
    The thickening of basement membrane in synovial capillaries in rheumatoid arthritis (1983)
    Springer
    Rheumatology international 3 (1983), S. 57-64 
    Details
    ISSN: 1437-160X
    Schlagwort(e): Basement membranes ; Basement membrane thickening ; Synovial capillaries ; Rheumatoid arthritis ; Endothelial cells
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Synovial tissues from seven rheumatoid arthritis (RA) patients were used for the ultrastructural investigation of capillary cellular components and basement membranes (BM). Attention has been specially paid to the mechanism of BM thickening of the capillaries in the inflammatory sites. The capillary BM were multilamellated in the inflammatory sites. The multilamellation was characteristic not only in the BM surrounding the endothelial cells and pericytes but also in the BM between these two types of cells. Cell debris was frequently encountered between the multilamellated BM. The hyperplasia and various stages of degeneration of the endothelial cells were observed in these regions. Some endothelial cells were activated and occasionally located in capillaries containing degenerated endothelial cells. The high incidence of these findings indicates the following hypotheses. The accelerated rate of death and replenishment of capillary cellular components may play a role in BM thickening in the inflammatory sites of RA synovium. These cells may not only produce one layer of BM in their life-time but may also be activated to produce excessive amounts of BM components to make several layers.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00541145
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  • 4
    Digitale Medien
    Digitale Medien
    The localization of fibronectin in rheumatoid arthritis synovium by light and electron microscopic immunohistochemistry (1983)
    Springer
    Rheumatology international 3 (1983), S. 153-159 
    Details
    ISSN: 1437-160X
    Schlagwort(e): Fibronectin ; Rheumatoid arthritis ; Synovial tissue ; Cell adhesion ; Opsonization
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The distribution of fibronectin in rheumatoid arthritis (RA) synovium has been investigated by light and electron microscopic immunohistochemistry using an antihuman fibronectin antibody. Heavy accumulation of fibronectin was observed in the lining layer and the areas of proliferation of fibroblasts. Rough endoplasmic reticulum (RER) and peripheral vesicles of proliferated type B lining cells and fibroblasts contained large amounts of fibronectin. Thus these cells seem to participate actively in the local synthesis and secretion of this glycoprotein. Type A lining cells and migrated mononuclear phagocytes contained many phagolysosomes in some of which dense accumulation of fibronectin was observed. Some of the materials in the phagolysosomes, with dense accumulation of fibronectin, resembled the fibrinous material-fibronectin complexes frequently seen in the pericellular spaces. Accordingly fibronectin seems to play a role in the clearance of fibrinous materials by these phagocytes. The proliferated capillaries and small vessels possessed multilamellated basement membranes with heavy accumulation of fibronectin. However, RER or Golgi apparatus of the endothelial cells contained no detectable amounts of fibronectin. This indicates that these cells do not actively participate in the synthesis of fibronectin and that the majority of this glycoprotein in the basement membranes originates in fibronectin from blood vessel exudate. Fibrinous material-fibronectin complexes were frequently seen on the endothelial cell surfaces. Circulating platelets and mononuclear cells occasionally came in contact with these complexes, suggesting an association of fibronectin with the formation and clearance of thrombi in the vascular lumina at the inflammatory sites of RA synovium.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00541594
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  • 5
    Digitale Medien
    Digitale Medien
    Intestinal Enterocytozoon bieneusi microsporidiosis in an HIV-infected patient: diagnosis by ileo-colonoscopic biopsies and long-term follow up (1992)
    Springer
    Journal of molecular medicine 70 (1992), S. 1019-1023 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Microsporidiosis ; Enterocytozoon bieneusi ; Diarrhea in HIV-infected persons ; Wasting syndrome ; Intestinal parasites
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A 39-year-old patient with acquired immunodeficiency syndrome was diagnosed as having intestinal Enterocytozoon bieneusi microsporidiosis after persistent watery diarrhea for 30 months and a 16-kg weight loss. Microsporidian parasites were found by light and electron microscopy in tissue specimens of the duodenum, jejunum, and terminal ileum, and by light microscopic examination of stool specimens. When duodenal tissue sections obtained 16 months previously were reviewed retrospectively, E. bieneusi was also found. Until now, diagnosis of intestinal microsporidiosis has been based on examination of bioptic specimens of the upper small intestine because the sensitivity of new coprodiagnostic techniques has not been determined. Our findings of ileal microsporidiosis show that examination of the terminal ileum and ileal biopsy collection in tandem with colonoscopy is indicated for patients infected with human immunodeficiency virus and suffering from unexplained chronic diarrhea. The long-term course of our patient demonstrates that E. bieneusi, although not necessarily life threatening, can cause protracted debilitating diarrhea and wasting in severely immunodeficient patients.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00180312
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  • 6
    Digitale Medien
    Digitale Medien
    Crystallization in vivo of Rhabdophane in Human Lungs (1973)
    [s.l.] : Nature Publishing Group
    Nature 241 (1973), S. 49-49 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] The X-ray powder diffraction pattern of the isolated lung dust does not show any additional lines except those of quartz which can be traced in every human lung. A semiquantitative X-ray fluorescence analysis showed the presence of the following elements (in order of decreasing frequency): cerium, ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/241049a0
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  • 7
    Digitale Medien
    Digitale Medien
    Ultrastructure of lipids in the optic nerve of the mouse mutant “Jimpy” (1979)
    Springer
    Acta neuropathologica 45 (1979), S. 221-229 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Mouse mutant Jimpy ; Optic nerve ; Lipid ultrastructure ; Phagolysosomes ; Phagocytes ; Histochemistry ; Freeze-etching ; Thin sections
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Optic nerves of the mouse mutant Jimpy and controls were studied in different developmental stages. The results cast some light on the nature and ultrastructure of intracellular lipids, which are a striking feature in the CNS of these affected mice. Light Microscopy. In the premyelination period the activity of acid phosphatase is quite similar in the lysosomes of both animal groups. A much higher increase of reaction product was found in Jimpy compared to controls during the advanced myelination stages. The normal glial cell arrangement in rows is absent in leucodystrophic animals. Electron Microscopy. Replicas of freeze-etched Jimpy optic nerves show lipid loaded cells exhibiting a plasma membrane different from that of astrocytes and oligodendrocytes, thus suggesting a relationship to phagocyting microglia. Furthermore, the rare myelin membranes are almost particle free. Three types of structurally different lipid inclusions could be observed. Most of the lipidic bodies are surrounded by a membrane studded with particles. The freeze-fractured morphology of the lipid inclusions was compared with the appearance in thin sections, incubated for acid phosphatase demonstration. Acid phosphatase reaction product within all three types of lipid containing vesicles indicate the lysosomal nature of these structures, which may represent myelin breakdown products and/or myelin precursors.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00702674
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  • 8
    Digitale Medien
    Digitale Medien
    Ungewöhnliche kristalline Einschlüsse in Plasmozytomzellen des Hodens bei primär medullärem Plasmozytom (1996)
    Springer
    Der Pathologe 17 (1996), S. 455-458 
    Details
    ISSN: 1432-1963
    Schlagwort(e): Schlüsselwörter Plasmozytom ; Hoden ; Kristall ; Kristallbildung ; Antikörper ; Key words Plasmacytoma ; Testicle ; Crystal ; Crystal formation ; Antibodies
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Summary At the autopsy of a 68 year old man with plasmacytoma of the λ light chain type we found polygonal interstitial cells with unusual crystalline inclusions, which were not readily identifiable and slightly resembled Leydig cells in conventional microscopy. In electron microscopy these could be identified as plasmacytoma cells, representing a testicular involvement. Comparable cells could be shown in the bone marrow. In immunochemistry we found a polyclonal reaction for λ light chains suggesting a similar phenomenon as the so-called Russell bodies. As far as we know the literature, this finding in a testicular metastasis has not been described.
    Notizen: Zusammenfassung Bei der Autopsie eines 68 jährigen Patienten mit einem Plasmozytom vom Leichtkettentyp λ fanden wir im Hodeninterstitium polygonale teils mehrkernige Zellen mit ungewöhnlichen kristallinen Einschlüssen, welche sich lichtoptisch nicht klar identifizieren ließen und entfernt an Leydig-Zellen erinnerten. Erst elektronenmikroskopisch konnten diese als Plasmozytomzellen, bei Vorliegen eines Hodenbefalls, identifiziert werden. Vergleichbare Zellen wurden auch im Knochenmark gefunden. Immunhistochemisch konnte eine polyklonale Immunoreaktivität für Leichtketten des Typs λ nachgewiesen werden, so daß ein den Russell-Körperchen ähnliches Phänomen angenommen werden muß. Unseres Wissens wurde ein solcher Befund bei einer Hodenmetastase noch nie beschrieben.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002920050186
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  • 9
    Digitale Medien
    Digitale Medien
    Oral cornstarch therapy: Is persorption harmless? (1993)
    Springer
    European journal of pediatrics 152 (1993), S. 592-594 
    Details
    ISSN: 1432-1076
    Schlagwort(e): Cornstarch ; Maize starch ; Persorption ; Glycogenosis type I
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Sediments prepared from freshly voided urine of four patients with glycogenosis Ia, or leucine-sensitive hypoglycaemia, on oral cornstarch therapy contained starch granules, evidence for persorption i.e. the incorporation of undissolved starch particles. In these patients, amyluria was more marked than in untreated controls. While cornstarch therapy is successful and causes few side-effects, the possibility of late adverse reactions to persorbed starch should not be disregarded.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01954087
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  • 10
    Digitale Medien
    Digitale Medien
    Achondrogenesis type I: Light and electron-microscopic studies (1980)
    Springer
    European journal of pediatrics 134 (1980), S. 69-74 
    Details
    ISSN: 1432-1076
    Schlagwort(e): Achondrogenesis type I ; Ultrastructure ; Chondrocytes ; Cytoplasmic inclusions
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The light- and electron-microscopic structure of articular and costal cartilage in a case of achondrogenesis type I has been described. The most characteristic ultrastructural change in the chondrocytes was conspicuous dilatation of the rough endoplasmatic reticulum (RER) which contained amorphous electronopaque material. This change in the RER was accompanied by marked hypertrophy of the Golgi apparatus; the matrix was basically unchanged.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00442406
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