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  • 1
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 50 (1988), S. 0 
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: Inner retinal cells including dopamine (DA) cells were isolated and fractionated from the carp (Cyprinus carpio) retina by an enzyme cell dissociation and metrizamide gradient centrifugation method. When γ-aminobutyric acid (GABA) antagonists (bicuculline and picrotoxin) were added into the perfusate over such a cell fraction, they stimulated the release of [3H]DA which had been preloaded in the cell fraction. The action of GABA antagonists was dose and Ca2+ dependent. Their minimal effective concentration was very low (0.5 μM). A similar action was elicited by high K+. In the presence of excess GABA, this stimulatory action of GABA antagonists and high K+ on [3H]DA release was completely abolished. To interpret the action of GABA antagonists on DA cells, isolated cell fractions were preincubated with GABAse. After such a treatment, the stimulatory effects of GABA antagonists and high K+ on [3H]DA release were differentiated from each other; the former disappeared whereas the latter remained unchanged. The data strongly suggest that GABA inhibits the DA release from retinal DA cells and thus the GABA antagonists affect [3H]DA release from cell fractions not by a direct membrane action but by a disinhibition mechanism via GABA receptors on the DA cell bodies.
    Materialart: Digitale Medien
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  • 2
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 54 (1990), S. 0 
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: Calcium-dependent phospholipid-sensitive protein kinase [protein kinase C (PKC)] was partially purified from the carp (Cyprinus carpio) retina through DE 52 ion exchange and Cellulofine gel filtration chromatography. The phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) activated PKC in the nanomolar range. A major 38-kDa protein in the retinal supernatants (105,000 g) was phosphorylated in vitro by PKC during a short period (3 min). Other phosphoproteins also appeared during a further prolonged period (〉15 min). Rod-bipolar and dopamine (DA) interplexiform cells in the fish retina were immunoreactive to a monoclonal antibody to PKC (α/β-subtype). The PKC antibody recognized a 78-kDa native PKC enzyme by means of an immunoblotting method. Subsequently, the effects of two kinds of PKC activators were investigated on [3H]DA release from retinal cell fractions containing DA cells that had been preloaded with [3H]DA. A phorbol ester (TPA) induced a calcium- and dose-dependent [3H]DA release during a short period (2 min), with the minimal effective dose being 1 nM. Other phorbols having no tumor-promoting activity, such as 4β-phorbol and 4α-phorbol 12, 13-didecanoate, were ineffective on [3H]DA release. A synthetic diacylglycerol [1-oleoyl-2-acetylglycerol (OAG)], which is an endogenous PKC activator, was also able to induce a significant release of [3H]DA. Furthermore, TPA was found to release endogenous DA from isolated fish retina by a highly sensitive HPLC with electrochemical detection method. The OAG- or TPA-induced [3H]DA or DA release was completely blocked by inhibitors of PKC, such as 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H7) and staurosporine. In contrast, release of [3H]glycine, γ-[3H]aminobutyric acid, and D-[3H]aspartic acid was never induced by TPA. Taken together, the present data indicate that TPA or OAG triggers a release of DA synaptically and that the induction is due to a PKC activation specifically in the membrane of DA cells in the fish retina. The functional role of PKC in rod-bipolar cells is unknown at present.
    Materialart: Digitale Medien
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  • 3
    Digitale Medien
    Digitale Medien
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 62 (1987), S. 3656-3659 
    ISSN: 1089-7550
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: Boron doping into silicon has been investigated using an ArF excimer laser. Dopant atoms are obtained by pyrolysis of BF3. Two kinds of doping, the doping in BF3 ambients and the doping using adsorbed layers, have been performed. In both cases, the sheet resistance decreases with increasing the number of pulses. The surface concentration and the junction depth increase with the number of pulses. From these results, it is found that dopant atoms are supplied from only adsorbed layers of BF3 formed on the silicon surface. Moreover, the supply of dopant atoms from adsorbed layers limits the doping process.
    Materialart: Digitale Medien
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  • 4
    ISSN: 1089-7623
    Quelle: AIP Digital Archive
    Thema: Physik , Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: A design of a microspectrophotometric system using a synchrotron radiation (SR) source is described. The system covers a wide spectral range of 50–13000 cm−1, being under construction at the UVSOR BL6B beamline in the Institute for Molecular Science. Preliminary experiments in the mid-infrared region (500–5000 cm−1) have qualitatively confirmed the theoretical calculation that the synchrotron radiation is more intense than a blackbody (T=1200 K) when a microspectrophotomeric technique is applied, which is due to natural collimation and high brilliance of SR source. The SR as an infrared source exhibits its advantage on measuring the spectra of small single crystals especially in the far-infrared region.
    Materialart: Digitale Medien
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  • 5
    Digitale Medien
    Digitale Medien
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 5 (1998), S. 292-299 
    ISSN: 1089-7674
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: By using a particle-in-cell simulation code which includes tunneling ionization, it is found that strong wake fields are excited and amplified due to the modulation of an intense laser pulse induced by an ionizing plasma in the regime where the matching condition between laser pulse length (LLaser) and plasma wavelength (λp), i.e. LLaser≤λp is not satisfied. The modulation is characterized by a gradual steepening of the pulse front where there is a copropagating density gradient which is due to the rapid plasma formation from ionization there. Accordingly, the wake field is convectively amplified to a significant level. This amplification of plasma waves always occurs, more or less, for laser propagation in ionizing plasmas. © 1998 American Institute of Physics.
    Materialart: Digitale Medien
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  • 6
    Digitale Medien
    Digitale Medien
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 2 (1995), S. 3100-3105 
    ISSN: 1089-7674
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: The self-similar distribution of electrons is found for a nonuniform underdense plasma that is heated by an intensive laser field. The distribution function is flat-topped for the low-energy electrons. And in the high-energy region, it has a well-pronounced high-energy tail. It is also found how the electron heat flux and the absorption coefficient depend upon both the ratios of electron mean-free path to the inhomogeneity scale of effective temperature and of the oscillation velocity to the thermal velocity. The actual shapes of electron energy distribution, the heat flux limitation, and the electromagnetic radiation absorption rate are given, both for a currentless plasma and for a plasma with a finite electric current. © 1995 American Institute of Physics.
    Materialart: Digitale Medien
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  • 7
    Digitale Medien
    Digitale Medien
    New York, NY : American Institute of Physics (AIP)
    Physics of Fluids 5 (1993), S. 564-570 
    ISSN: 1089-7666
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: The nonlinear interaction of an ultrashort-pulse laser with a solid target is investigated by using a newly developed particle simulation code, which enables the analysis of laser–plasma interaction in the very steep density gradient in which the laser light penetrates into an overdense plasma. For an ultrashort laser pulse, the plasma density scale length Ld satisfies Ld≤r0 for an electron excursion length r0. Laser absorption and electron acceleration processes are proposed for the above situation. It is found that the wave breaking is the main mechanism of the electron acceleration and laser absorption, as is discussed in Brunel's paper [Phys. Rev. Lett. 59, 52 (1987)].
    Materialart: Digitale Medien
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  • 8
    Digitale Medien
    Digitale Medien
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 60 (1989), S. 1793-1793 
    ISSN: 1089-7623
    Quelle: AIP Digital Archive
    Thema: Physik , Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: The design of the next generation synchrotron radiation ring is based on a low-emittance storage ring with large numbers of zero-dispersion straight-section for insertion devices. As a candidate, the Chasman-Green lattice is likely to be the most promising to be investigated. In this paper, field gradients and edges which are not perpendicular to the optic axis are proposed to introduce the bending magnets for a low-emittance Chasman-Green lattice. The horizontal beam emittance of a large ring is generally expressed as1 (1) εx=Cqγθ3F(ψ)/Jx, where Cq=3.83×10−13 m, γ=Lorentz factor of the stored beam, θ=bending angle of a dipole magnet, F(ψ)=emittance form factor as a function of the betatron phase advance per half cell ψ, Jx=partition number of the horizontal betatron oscillation.The form factor F(ψ) depends on the lattice structure and is expressed for the symmetrical cell as (2) F(ψ)=(1/ρθ3)(1/ρθ) ∫ρθ0(γη2 +2αηη'+βη'2)ds, where H=γη2+2αηη'+βη'2 is the Courant–Snyder dispersion invariant, ρ is the magnetic radius, α, β, γ are Twiss parameters and η, η' are the dispersion function and the derivative with s the integral ranges over a bending magnet. We calculate, for examples, F(ψ) for a single lens approximation of equal focal length with ρ=25 and θ=π/32 radian. For the gradient magnet, the gradient parameter K is taken to be −0.05(1/m2) for example, where K is defined as (3) K=(1−n)/2, n=−(ρ/B)(dB/dx). The absolute value of K is restricted to be small to guarantee the damping of energy oscillation. For a nonperpendicular edge, the angle between the edge normal and the beam axis is chosen to be −0.255 radian, for example. The sign conversion is in the usual manner.2 The form factor F(ψ) is calculated as a function of Ψ for the two examples. Another factor to effect the emittance is the partition number Jx as seen in Eq. (1).Jx can be written as (4) Jx=1−Kρ2θ2/3, in the first-order calculation. A negative K has little effect to decrease the emittance in cooperation with F(ψ). The horizontal beam emittance is shown to be decreased by the reduction of the factor in two examples in cooperation with the increase of the horizontal damping partition number of the betatron oscillation.
    Materialart: Digitale Medien
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  • 9
    Digitale Medien
    Digitale Medien
    s.l. : American Chemical Society
    Journal of the American Chemical Society 99 (1977), S. 620-622 
    ISSN: 1520-5126
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 10
    Digitale Medien
    Digitale Medien
    s.l. : American Chemical Society
    Journal of the American Chemical Society 93 (1971), S. 3074-3075 
    ISSN: 1520-5126
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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