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  • 1
    ISSN: 1436-2813
    Schlagwort(e): Key Words: adrenal gland ; autotransplantation ; omental wrapping
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: 131 I]-iodomethyl-norcholesterol ([131I]-Adosterol) demonstrated clear activity in the omentum, weak activity in the rectus muscles, and no activity in the adrenal beds. These findings suggest that the omentum may be more suitable as an implantation site for adrenal tissue than muscular pockets.
    Materialart: Digitale Medien
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Surgery today 30 (2000), S. 333-338 
    ISSN: 1436-2813
    Schlagwort(e): Key Words: parathyroid gland, preservation, autotransplantation, total thyroidectomy, intact parathyroid hormone
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract: To prevent postoperative hypoparathyroidism following total thyroidectomy, the parathyroid glands are preserved in situ and/or resected or devascularized parathyroid glands are autotransplanted. We conducted a retrospective investigation utilizing biochemical and specific endocrine assessments to evaluate the difference in recovery of parathyroid function between the two operative methods. A total of 92 patients underwent total thyroidectomy at our hospital during the period between 1990 and 1997. These patients were divided into a preservation group (n = 83), with one or more preserved glands in situ, and an autotransplantation group (n = 9), with only transplanted glands. The level of intact parathyroid hormone (PTH) was completely restored by 1 year postoperatively in 83% (69/83) of the preservation group patients. In the remaining 14 patients (17%), the intact PTH had fallen below detectable levels on postoperative day (POD) 1, then subsequently recovered to 70% of the preoperative levels. Comparatively, in the autotransplantation group, the mean level of intact PTH recovered to only 43% of the preoperative levels. The results of this study suggest that parathyroid glands should be preserved in situ whenever possible, and that when intact PTH levels fall below detectable limits on POD 1, they may never recover to the preoperative levels in those patients.
    Materialart: Digitale Medien
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  • 3
    ISSN: 1436-2813
    Schlagwort(e): adrenal gland ; autotransplantation ; omental wrapping
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Bilateral total adrenalectomy results in the need for patients to take lifelong supplements of adrenal steroids, with the risk of possible Addisionian crisis. Few reports of the successful autotransplantation of adrenal tissue in muscular pockets have been documented; however, we describe herein the case of a 22-year-old woman in whom autotransplantation of an adrenal gland was successfully performed employing a new method of omental wrapping. The patient underwent bilateral total adrenalectomy for bilateral pheochromocytoma at which time adrenal tissue was sliced into 1–2-mm thick pieces, half of which were placed in muscular pockets in the abdominal rectus muscles, and the remaining half put onto the omentum and wrapped with it. Laboratory examinations done 6 months after surgery showed recovery of her adrenal function, and 4 months later steroid supplements were able to be discontinued. Scintigraphic studies using [131I]-iodomethylnorcholesterol ([131I]-Adosterol) demonstrated clear activity in the omentum, weak activity in the rectus muscles, and no activity in the adrenal beds. These findings suggest that the omentum may be more suitable as an implantation site for adrenal tissue than muscular pockets.
    Materialart: Digitale Medien
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  • 4
    Digitale Medien
    Digitale Medien
    Springer
    World journal of surgery 16 (1992), S. 688-689 
    ISSN: 1432-2323
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
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  • 5
    ISSN: 1432-2323
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. A greater percentage of thyroid cancers can be detected by ultrasound-guided fine-needle aspiration biopsy (UG-FNAB) than by ordinary FNAB. A group of 678 patients were selected sequentially as having been diagnosed with benign nodules by the conventional FNAB method. We reexamined these patients by UG-FNAB and investigated the types of thyroid cancer that were missed by the conventional FNAB. Of the 678 patients diagnosed with benign nodules (using conventional FNAB), 571 (84.2%) demonstrated the same diagnosis when UG-FNAB was used. The remaining 107 patients (15.8%) studied were suspected of having a malignancy after UG-FNAB had been performed. Surgical specimen histology proved thyroid cancer in 99 of the 107 patients: 93 had papillary carcinoma, 4 had follicular carcinoma, 1 had medullary carcinoma and 1 had anaplastic carcinoma. Two drawbacks were noted when conventional FNAB was used: (1) cancer lesions difficult to palpate ( n = 55) (e.g., small cancers with or without benign lesions or cancers associated with Hashimoto’s thyroiditis or Graves’ disease); and (2) palpable cancers with insufficient cell material for analysis ( n = 44) (e.g., cystic carcinoma and cancers with calcified lesions. UG-FNAB is a powerful technique for detecting microcancers, cystic carcinomas, cancers associated with benign nodules, Hashimoto’s thyroiditis, or coarse calcifications.
    Materialart: Digitale Medien
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  • 6
    Digitale Medien
    Digitale Medien
    Springer
    World journal of surgery 18 (1994), S. 495-498 
    ISSN: 1432-2323
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Résumé L'évolution des patients ayant été opérés d'un nodule bénin de la thyroïde n'est pas connu car il n'y a pas d'étude sur ce sujet. Nous avons réexaminé 134 patients porteurs de nodule thyroïdien ayant eu une ponction diagnostique avec cytologie 9 à 11 ans auparavant. La thyroïde était palpée par les mêmes cliniciens durant la totalité de l'étude. Pour tous les nodules ayant persisté entre 9 et 11 ans, on a pratiqué un examen echographique et une ponction à l'aiguille fine avec cytologie. Ceux qui avaient des nodules kystiques ou difficiles à repérer par la palpation (petite taille) ou encore de nodules multìples ont eu une ponction échoguidée (N=55) alors que les autres patients ont eu une ponction simple. Aucun de ces patients avait eu un traitement médical ou chirurgical. Il y avait 86 nodules simples, 14 nodules multiples et 34 nodules kystiques. De 9 à 11 ans après, 42% à 79% des nodules bénins avaient soit disparu soit diminué de taille. Environ 92% des nodules sont restés bénins, sans changer de classification histologique. Un seul des nodules (0.9%), toujours considéré comme nodule bénin, était en réalité malin. Ce nodule avait augmenté de taille dans l'intervalle. Parmi les nodules simples ou multiples, 21 à 23% des nodules avaient augmenté de taille. La plupart de ces patients (86%) avaient la même cytologie qu'auparavant (classe 2). Les résultats de notre étude indiquent que les nodules bénins le restent pendant de longues années. Aucun traitement médical ou chirurgical n'est nécessaire à condition que les nodules n'augmentent pas de taille.
    Kurzfassung: Resumen La evolución final de los nódulos tiroideos benignos es desconocido, por cuanto realmente no existen estudios pertinentes. Hemos re-examinado 134 pacientes con nódulos tiroideos que habían sido sometidos a aspiración-bíopsiacitología 9 a 11 años antes. La glándula tiroides fue examínada por palpación a cargo de los mismos tiroidólogos en el curso del estudio. El ultrasonido, la aspiración con aguja fina (AAF) y la aspiración con aguja fina guiada por ultrasonido fueron los métodos empleados para examinar la naturaleza de los nódulos de 9 a 11 años de duración. Los pacients (n=61) que poseían nódulos difíciles de palpar (nódulos pequeños), nódulos múltiples o nódulos quísticos con proliferación palilomatosa fueron sometidos a AAF guiada por ultrasonido; los pacìentes (n=55) que poseían nódulos únicos claramente palpables fueron sometidos a AAF simple. Ninguno de los pacientes recibió tratamiento médico o quirúrgico alguno. En el primer examen se hallaron 86 nódulos únicos, 14 nódulos múltiples y 34 nódulos quísticos, y éstos nódulos benignos fueron re-examinados para determinar cambio en su tamaño 9 a 11 años más tarde. El hallazgo más notorio fue una disminución del tamaño o la desaparición del nódulo en 42% a 79% de los casos. Alrededor de 92% de los nódulos se mantuvieron con características benignas, sin cambio en la clasificación histológica. Sólo un caso (0.9%), previamente considerado como benigno, resultó ser maligno; este nódulo aumentó en tamaño en comparación al examen previo. Entre los nódulos únicos y múltiples, 21% a 23% aumentaron de tamaño; sin embargo, la mayoría de los pacientes con nódulos acrecentados en su tamaño (86%) exhibieron la misma citología clase 2 que antes. El presente estudio indica que el nódulo que prueba ser benigno por biopsia sigue siendo benigno en el curso de un prolongado período de tiempo. Por consiguiente, no se requiere tratamiento médico o quirúrgico mientras el nódulo no aumente de tamaño.
    Notizen: Abstract The fate of benign thyroid nodules has been unknown because there has been no study in this regard. We re-examined 134 patients with thyroid nodules who had had benign aspiration biopsy cytology 9 to 11 years ago. The thyroid gland was palpated by the same two thyroidologists throughout the study. Ultrasonography, fine-needle aspiration biopsy (FNAB), and ultrasound-guided FNAB were employed to examine the nature of nodules of 9 to 11 years' duration. Patients (n=61) who had nodules difficult to palpate (small nodules), multiple nodules, or cystic nodules with papillomatous proliferation underwent ultrasound-guided PNAB; patients (n=55) having a distinctly palpable single nodule underwent usual FNAB. None of the patients received any medical or surgical treatment. There were 86 single nodules, 14 multiple nodules, and 34 cystic nodules on the first examination. These benign nodules were reexamined for changes in size and cytology 9 to 11 years later. The most striking finding was a decrease in size or disappearance of the nodule in 42% to 79% of benign nodules. About 92% of nodules remained benign without changing cytologic classification. Only one case (0.9%) previously regarded as benign turned out to be malignant; this nodule grew in size compared with the previous examination. Among single and multiple nodules, 21% to 23% of the nodules increased in size; however, most patients with enlarged nodules (86%) showed the same class 2 cytology as before. Our present study indicates that biopsy-proved benign thyroid nodules remain benign over a prolonged period. Thus no medical or surgical treatment is required so long as the nodules do not grow.
    Materialart: Digitale Medien
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  • 7
    ISSN: 1432-2323
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. Thyroid lymphoma occurs most commonly in the thyroid gland in association with Hashimoto’s thyroiditis. Histologic findings occasionally cannot distinguish lymphoma from Hashimoto’s thyroiditis, which creates a serious problem of whether treatment should be initiated. For this study, we examined 33 lymphoma tissues and 10 thyroid tissues from patients with Hashimoto’s thyroiditis for the presence of gene rearrangement of immunoglobulin, which represents clonality of B-cell-derived tumors. Genomic DNA from thyroid tissues was digested with Bam H1 and Hind III restriction enzymes followed by electrophoresis. A Southern blot was performed with an IgH-JH probe or IgL-Jκ probe to detect gene rearrangement. Of the 33 lymphoma tissues, 27 (85%) showed gene rearrangement of immunoglobulin, whereas none of Hashimoto’s thyroiditis tissue showed gene rearrangement. Five patients with a positive histologic diagnosis of lymphoma showed a negative gene rearrangement and were treated as having lymphoma. We encountered one case of lymphoma (plasmacytoma) in which gene rearrangement (not histologic findings) was diagnostic. Gene rearrangement of immunoglobulin can be used to detect thyroid lymphoma, particularly when the histologic diagnosis is inconclusive. The sensitivity of detecting thyroid lymphoma by the Southern blot method was about 85% in the present series.
    Materialart: Digitale Medien
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  • 8
    ISSN: 1432-2323
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. Compared to hereditary medullary thyroid carcinoma (MTC), sporadic MTC tends to be unicentric and confined to one lobe. Patients with sporadic MTC usually undergo total thyroidectomy because of a possible hereditary or bilateral process. We evaluated the usefulness of germline RET oncogene mutation analysis in surgery for apparently sporadic MTC and performed unilateral surgery on patients without detectable mutation. In 36 patients with a preoperative diagnosis of apparently sporadic MTC, we performed germline RET oncogene mutation analyses: before surgery in 8 recent patients and after surgery in 28 who had been treated before 1996. Of the latter, 5 had bilateral MTC. DNA samples were extracted from their peripheral blood, and the polymerase chain reaction products of the RET proto-oncogene were analyzed using single-strand conformation polymorphism analysis and the direct sequencing methods. Before 1996 we often performed total thyroidectomy but changed to hemithyroidectomy thereafter, except in one patient with associated Graves' ophthalmopathy. Our minimal standard practice included systematic central and ipsilateral neck dissection. The outcome was assessed in terms of gastrin- and calcium-stimulated plasma calcitonin levels. Germline RET mutations were found in six patients. Five of these patients had bilateral MTC, whereas all 30 patients without mutation had unilateral disease. Hemithyroidectomy in seven of our recent patients resulted in normalization of plasma calcitonin levels in all, although four were found to have microscopic lymph node involvement. In conclusion, hemithyroidectomy with systematic central and ipsilateral neck dissection is an appropriate procedure for patients with sporadic MTC without detectable germline RET mutations.
    Materialart: Digitale Medien
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  • 9
    ISSN: 1349-9432
    Schlagwort(e): Brillouin scattering ; polarization maintaining fiber ; squeezed light ; photoelastic effect ; fiber loop mirror
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract Characteristics of guided acoustic wave Brillouin scattering in polarization maintaining fibers are investigated theoretically and experimentally. Spectra of polarized and depolarized scattering are measured for two different types of polarization maintaining fibers: the PANDA (polarization maintaining and absorption reducing) fibers and the elliptical-jacket fibers. Calculated results are in agreement with the experimental ones in the low frequency region.
    Materialart: Digitale Medien
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  • 10
    ISSN: 1432-2323
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Résumé Dix malades présentant un cancer médullaire thyroïdien et 2 malades un cancer papillaire ont été soumis à une scintigraphie employant un nouveau radioisotope le99mTc(V)-DMS. Au cours de l'intervention une dose traçante de ce nouvel agent fut injectée par voie intraveineuse pour permettre l'étude de sa répartition au niveau de la pièce opératiore. Parmi les malades atteints de cancer médullaire 7 sur 10 ont présenté des images scintigraphiques patentes, 2 des images estompées cependant qu'un malade qui était porteur d'une récidive au niveau d'un ganglion lymphatique ne présentait pas d'image significative. Chez 3 malades une diffusion médiastinale fut clairement démontrée et la dissection médiastinale vint confirmer les constatations scintigraphiques. En revanche aucune image ne fut observée chez les malades atteints de cancer papillaire. Les études de la distribution tissulaire du99mTC(V)-DMS démontrent une imprégnation spécifique importante du néoplasme médullaire par rapport aux autres tissus. Ce nouvel agent scintigraphique de dépistage du cancer médullaire thyroïdien est d'une grande valeur pour déterminer la conduite opératoire et pour suivre le malade après l'intervention.
    Kurzfassung: Resumen Diez pacientes con carcinoma medular de tiroides (CMT) y 2 pacientes con carcinoma papilar fueron investigados mediante centelleografía utilizando99mTc(V)-ácido dimercaptosuccínico, un nuevo agente radiofarmacéutico para imágenes de CMT. En el curso de la cirugía se administró una dosis trazadora del agente por vía intravenosa, y su distribución fue estudiada en los tejidos de la resección quirúrgica. Entre los pacientes con CMT, 7 presentaron imágenes claras de centelleografía del tumor, 2 presentaron imágenes débiles, y 1 paciente con tumor recurrente en un ganglio linfático no exhibió imagen de significación. En 3 pacientes la invasión mediastinal pudo ser claramente demostrada, y la disección mediastinal confirmó los hallazgos de la centelleografía. No se obtuvieron imágenes significativas en los pacientes con carcinoma papilar. Los estudios de distribución tisular del99mTc(V)-ADMS revelaron acumulación específica del agente en tejido de CMT y baja captación por otros tejidos. Este nuevo método de centelleografía para CMT es de gran valor para decidir sobre el aproche quirúrgico y para el seguimiento.
    Notizen: Abstract Ten patients with medullary thyroid carcinoma (MTC) and 2 patients with papillary carcinoma of the thyroid were investigated by scintigraphy using99mTc(V)-dimercaptosuccinic acid [99mTc(V)-DMS], a new radiopharmaceutical agent for imaging MTC. At surgery, a tracer dose of the agent was administered intravenously, and the distribution of the agent was studied in the surgically removed tissues. Among the patients with MTC, 7 had clear scintigraphic images of tumors, 2 had faint images, and 1 patient with a recurrent tumor in a lymph node had no significant image. In 3 patients, mediastinal involvements were clearly demonstrated, and mediastinal dissection confirmed the scintigraphic findings. No significant images were obtained in the patients with papillary carcinoma. The tissue distribution studies of99mTc(V)-DMS revealed specific accumulation of the agent in MTC tissue and low uptake in other tissues. This new scintigraphy for MTC is of great value in deciding the surgical approach and follow-up.
    Materialart: Digitale Medien
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