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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 16 (1991), S. 0 
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Protein and N—linked glycoprotein biosynthesis was studied in histologically verified normal epidermis, actinic keratoses, keratoacanthoma, intra-epidermal carcinoma and squamous-cell carcinoma using polyacrylamide gel electrophoresis (PAGE). The PAGE profiles of 3[H]—leucine-labelled proteins and 3[H]-mannose-labelled glycoprotein from all disease states studied differed from each other and from normal epidermis. A large 3[H]-mannose-labelled glycoprotein region (band A) with a peak at 97–92 kDa appeared to indicate the presence of a relatively large proportion of basaloid cells in the tissue. An associated peak in the region of 78–74 kDa also appeared in normal epidermis and what appeared to be non-invasive lesions. The main region of change in all lesions corresponded to the 66–34-kDa region (bands B and C). The absence of a group of glycoproteins and proteins in the 62-58-kDa region appeared to be specific for invasive squamous-cell carcinoma. All tumours showed a peak at 38–34 kDa which was not present in normal epidermis. Actinic keratosis had a pattern similar to normal epidermis except that the peaks of band B tended towards the higher-molecular-weight end of the band than those in normal epidermis and peaks at 28–22 kDa were seen. The latter seemed to correspond to the presence of a high proportion of spinous cells in the tissue sample.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Water and environment journal 14 (2000), S. 0 
    ISSN: 1747-6593
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Whilst beach-profile surveying is a relatively long-established and widely utilised shoreline monitoring technique, a considerable gap exists between theoretical and practical requirements from, and uses of, beach-profile data. The paper bridges this gap by providing a summary of the key elements of beach-profile measurement, theory and analysis. The benefits of applying these elements to practical coastal management are given in three case studies. The first case study presents results from beach-profile analysis on a regional scale in East Anglia. The second case study applies both analytical and theoretical techniques to investigate erosional problems along a coastal bay in Jersey. The third case study assesses the performance of two major sand-replenishment schemes in Poole Bay (on the south coast of England) based upon beach-profile volumetric analyses. Most importantly, the paper demonstrates that beach-profile measurement, theory and analysis can provide information of practical use in coastal management.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 16 (1990), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The pattern of basement membrane deposition was investigated in benign and malignant choroid plexus tumours using an immunocytochemical method to detect laminin, an intrinsic basement membrane component. The results were compared with intracranial ependymomas and myxopapillary ependymomas of the filum terminale. Expression of the intermediate filaments cytokeratin and glial fibrillar acidic protein (GFAP) and the epithelial marker carcino-embroyonic antigen (CEA) was also assessed. Laminin was detected in a subepithelial location in all the choroid plexus tumours but in none of the ependymomas, although basement membrane fragmentation was seen in the choroid plexus carcinomas. In contrast. GFAP was present in all the types of tumour examined. Cytokeratin (as detected by CAM 5.2) was present in all the choroid plexus lesions and also in the ependymomas arising in the spinal canal. CEA was not detected. We conclude that immunostaining for laminin assists distinction between choroid plexus tumors and papillary ependymomas and between benign and malignant choroid plexus tumours.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial and engineering chemistry 7 (1968), S. 172-177 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial and engineering chemistry 7 (1968), S. 362-366 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Medicine 41 (1990), S. 239-250 
    ISSN: 0066-4219
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 33 (1968), S. 4315-4315 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical journal international 99 (1989), S. 0 
    ISSN: 1365-246X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Palaeomagnetic analysis of 222 specimens from a high-resolution Late Devensian Lateglacial sedimentary sequence at Llyn Gwernan, North Wales has provided the first detailed record of geomagnetic secular variation for the Lateglacial period in Britain. This provides the opportunity to extend the British Holocene Geomagnetic Master Curve possibly as far back as 15 000 yr bp.The declination log records six well-defined oscillations with peak-to-peak amplitudes of 20–30°. The inclinations are shallower than expected for this latitude (52°44′N) which are probably due to the magnetic recording process although low geomagnetic inclinations are not ruled out. The inclination log defines a number of relatively smooth swings with peak-to-peak amplitudes of 10-20°. No evidence for any geomagnetic excursions (such as the Gothenburg ‘Flip’) was found.The Llyn Gwernan Lateglacial palaeomagnetic record is compared with the published palaeomagnetic records for a number of European sites. Correlations between records suggest that the ages of the Llyn Gwernan palaeomagnetic features, derived from a series of radiometric radiocarbon measurements, are in general compatible with those of the European sites. Discrepancies between the records are probably due to errors in radiocarbon dating of Lateglacial sediments and variability of the palaeomagnetic recording process and do not represent spatially-variable geomagnetic field behaviour.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 60 (2005), S. 0 
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The Cobra Perilaryngeal Airway™ (Engineered Medical Systems, Indianapolis, IN) is a new supraglottic airway designed for spontaneous and controlled ventilation. It is not yet commercially available in the UK. Our aim was to evaluate the performance of the Cobra Perilaryngeal Airway™ in a cohort study and in a randomised, controlled, crossover comparison study with the Classic Laryngeal Mask Airway™. After studying 29 patients, both studies were suspended and later stopped after two cases of significant pulmonary aspiration had occurred in patients whilst using the Cobra Perilaryngeal Airway™. These cases raised concern about both the design and the safety of the Cobra Perilaryngeal Airway™, particularly during controlled ventilation. We suggest that the Cobra Perilaryngeal Airway™ should not be marketed for controlled ventilation until more safety data are available.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 60 (2005), S. 0 
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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