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  • 1
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 50 (1988), S. 0 
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The metabolism and blood-brain transport of choline (Ch) were investigated in perfused canine brain under control conditions and for 60 min after inhibition of brain cholinesterases by the organophosphorus (OP) compounds soman (pinacolylmethylphosphonofluoridate) and sarin (isopropylmethylphosphonofluoridate). Ch and acetylcholine (ACh) in blood and brain samples were analyzed using gas chromatography-mass spectrometry methods. Net transport of Ch was determined by Ch analysis in arterial and venous samples. Unidirectional transport of [3H]Ch was determined using the indicator dilution method. During control perfusion periods of 90 min, net efflux of brain Ch occurred at a rate of 1.6 ± 0.4 nmol/g/ min, and the Ch content of the recirculated perfusate increased 10-fold to ˜8 μM. Brain Ch content increased in proportion to the increase in perfusate Ch level, but brain ACh was unaltered. Rapid administration of soman (100 Hg) or sarin (400 μg) into the arterial perfusate after a 40-min control period resulted in a 〉 10-fold increase in ACh content in cerebral cortex, brainstem, and hippocampus.The ACh content of cerebellum increased only slightly. The Ch level in all four brain regions studied also increased two-to fourfold above control levels. Ch efflux from brain, however, decreased to 0.2 ± 0.1 nmol/g/min during the 60 min after OP exposure. Unidirectional influx of [3H)Ch was 0.49 ± 0.07 nmol/g/min before and did not change significantly 10 or 40 min after OP exposure, thus indicating that the Ch transporter of the brain endothelial cell is not directly inhibited. Based on these results, it is proposed that (a) efflux of brain Ch occurs from the extracellular compartment, which becomes depleted when ACh breakdown is inhibited; (b) brain Ch is sequestered intracellularly; and (c) inhibition of cholinesterases by OP compounds stimulates synthesis of Ch, the source of which is not yet clear but which may involve hydrolysis of Ch-containing brain lipids.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    s.l. : American Chemical Society
    Journal of the American Chemical Society 109 (1987), S. 4717-4718 
    ISSN: 1520-5126
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    s.l. : American Chemical Society
    Journal of the American Chemical Society 109 (1987), S. 6187-6189 
    ISSN: 1520-5126
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Risk analysis 19 (1999), S. 0 
    ISSN: 1539-6924
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Energietechnik
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    Annales geophysicae 17 (1999), S. 1260-1267 
    ISSN: 0992-7689
    Schlagwort(e): Ionosphere (equatorial ionosphere; ionosphere-magnetosphere interactions; wave-particle interactions)
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Geologie und Paläontologie , Physik
    Notizen: Abstract The morphology of ELF hiss events observed at low-latitude ground station Varanasi (L = 1.07, geomagnetic latitude 14°55′N) are reported, which consist of two types: (1) events which propagated in ducted mode along the geomagnetic field line corresponding to observing station Varanasi and (2) events which propagated in ducted mode along higher L-values (L = 4–6), after reaching the lower edge of ionosphere excite the Earth-ionosphere wave guide and propagate towards equator to be received at Varanasi. To understand the generation mechanism of ELF hiss, incoherent Cerenkov radiated power from the low latitude and middle latitude plasmasphere are evaluated. Considering this estimated power as an input for wave amplification through wave-particle interaction, the growth rate and amplification factor is evaluated which is too small to explain the observed wave intensity. It is suggested that some non-linear mechanism is responsible for the generation of ELF hiss.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 6
    ISSN: 1539-6924
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Energietechnik
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of environmental contamination and toxicology 42 (1989), S. 860-867 
    ISSN: 1432-0800
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Energietechnik , Medizin
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 8
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of environmental contamination and toxicology 43 (1989), S. 28-35 
    ISSN: 1432-0800
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Energietechnik , Medizin
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    Springer
    Transition metal chemistry 18 (1993), S. 427-430 
    ISSN: 1572-901X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary The kinetics of iridium(III)-catalysed oxidation of 1,2-ethanediol and 1,4-butanediol by N-bromoacetamide (NBA) in HClO4 in the presence of [Hg(OAc)2] as a scavenger for Br− have been investigated. The reactions are zero-order with respect to both diols, and first-order in NBA at low NBA concentrations, tending to zero order at high concentrations. The order in IrIII decreases from unity to zero at high iridium(III) concentrations. A positive effect on the oxidation rate is observed for [H+] and [HgII] whereas a negative effect is observed for acetamide and [Cl−]. Ionic strength does not influence the oxidation rate. (H2OBr)+ is postulated as the oxidizing species. A mechanism consistent with the observed kinetic data is proposed.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 10
    Digitale Medien
    Digitale Medien
    Springer
    Mathematical geology 28 (1996), S. 111-132 
    ISSN: 1573-8868
    Schlagwort(e): discriminant analysis ; kriging ; principal component analysis ; robust M-estimation ; separation of mixed populations ; spatial trend
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Geologie und Paläontologie , Mathematik
    Notizen: Abstract Typically, datasets originated from mining exploration sites, industrially polluted and hazardous waste sites are correlated spatially over the region under investigation. Ordinary kriging (OK) is a well-established geostatistical tool used for predicting variables, such as precious metal contents, biomass, species counts, and environmental pollutants at unsampled spatial locations based on data collected from the neighboring sampled locations at these sites. One of the assumptions required to perform OK is that the mean of the characteristic of concern is constant for the entire region under consideration (e.g., there is no spatial trend present in the contaminant distribution across the site). This assumption may be violated by dalasets obtained from environmental applications. The occurrence of spatial trend in a dataset collected from a polluted site is an indication of the presence of two or more statistical populations (strata) with significantly different mean concentrations. Use of OK in these situations can result in inaccurate kriging estimates with higher SDs which, in turn, can lead to incorrect decisions regarding all subsequent environmental monitoring and remediation activities. A univariate and a multivariate approach have been described to identify spatial trend that may be present at the site. The trend then is removed by subtracting the respective means from the corresponding populations. The results of OK before and after trend removal are being compared. Using a real dataset, it is shown that standard deviations (SDs) of the kriging estimates obtained after trend removal are uniformly smaller than the corresponding SDs of the estimates obtained without the trend removal.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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