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  • 1
    Digitale Medien
    Digitale Medien
    Nb interaction with hydrogen plasma (2001)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 89 (2001), S. 760-766 
    Details
    ISSN: 1089-7550
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: A niobium membrane was immersed in hydrogen plasma and could be electrically biased to vary the energy of bombarding ions in the range of 1–200 eV. The fluxes of plasma driven absorption and permeation were almost entirely governed by incident suprathermal neutrals (mostly, thermal atoms), whose energy does not depend on membrane bias, but the ions of controllable energy do affect the neutral-induced permeation through modifying the membrane surface. At the zero bias a high temperature-independent plasma driven permeation (superpermeation) was observed alongside of an enhanced absorption. Bombardment by ions of an energy higher than 50 eV resulted in a sharp decrease of the plasma driven permeation/retention and in an acceleration of boundary processes of absorption/reemission of thermal molecules. At ion energies below 50 eV, the effect of ion bombardment on the plasma driven permeation and the kinetic coefficients of boundary processes were nonmonotonic in ion energy, having a maximum at ∼10 eV. Both an in situ doping with O of the bulk of Nb and a membrane temperature increase reduced the effects of ion bombardment to their complete disappearance. Responsible for that was the replenishment by means of surface segregation of an oxygen monolayer sputtered by ion bombardment. © 2001 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.1331075
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  • 2
    Digitale Medien
    Digitale Medien
    Extreme ultraviolet emission from Xe clusters excited by high-intensity lasers (2001)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 90 (2001), S. 3595-3601 
    Details
    ISSN: 1089-7550
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: The property of extreme ultraviolet (EUV) generation from Xe clusters irradiated with intense lasers was studied. The Xe cluster jet was well characterized by the interferometric method. In order to obtain the adequate irradiation condition for strong EUV generation, EUV spectra were taken with various laser systems. Then, the wavelength, the pulse width, and the pump energy were widely varied. Through this survey, even with the comparatively low-density Xe jet of ≤5×1018 cm−3 average atomic density, the highest conversion efficiency of over 10% from laser energy to EUV (5–18 nm) was obtained with a subpicosecond KrF laser pulse, where a 4π source was assumed. This EUV source is considered to be attractive as an EUV lithography light source because of its low average atomic density and small Xe cluster. © 2001 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.1396822
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  • 3
    Digitale Medien
    Digitale Medien
    Rethinking the role of tumour necrosis factor-α in ultraviolet (UV) B-induced immunosuppression: altered immune response in UV-irradiated TNFR1R2 gene-targeted mutant mice (2001)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 144 (2001), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background Ultraviolet (UV) B-induced immunosuppression, implicated in the pathogenesis of skin cancers, is postulated to be mediated in part by cis-urocanic acid (cis-UCA) via tumour necrosis factor (TNF)-α. TNF-α produces morphological changes in Langerhans cells indistinguishable from those induced by UVB exposure and antibodies against TNF-α have been demonstrated to inhibit UVB-induced immunosuppression in vivo. Objectives To clarify further the role of TNF-α in UVB-induced immunosuppression and in cis-UCA immunosuppression. Methods We performed a contact hypersensitivity (CHS) assay on gene-targeted mutant mice (TNFR1R2–/–) lacking genes for both receptors (p55 and p75) for TNF-α. Mice were either irradiated with UVB or injected intradermally with cis-UCA, sensitized with 2,4-dinitrofluorobenzene, challenged on the ears and the response was measured. Results The TNFR1R2–/– mice showed hyporesponsiveness in the CHS response compared with wild-type (P 〈 0·001), confirming the proinflammatory role of TNF-α. However, significant suppression of CHS was seen after irradiation and after cis-UCA injection in both locally (sensitization on irradiated site; P 〈 0·05) and systemically (sensitization on non-irradiated site; P 〈 0·05) sensitized wild-type and gene-targeted mice. Conclusions These results demonstrate that TNF-α signalling is only partially involved in UVB-induced immunosuppression and does not play a major part in the cis-UCA immunosuppression mechanism.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2133.2001.04181.x
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  • 4
    Digitale Medien
    Digitale Medien
    Development of chimeric molecules for recognition and targeting of antigen-specific B cells in pemphigus vulgaris (2000)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 142 (2000), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Pemphigus vulgaris (PV) is an autoimmune blistering disease characterized by circulating pathogenic IgG antibodies against desmoglein 3 (Dsg3). The purpose of this study was to develop chimeric molecules for specific recognition and elimination of autoimmune B cells in PV. Mouse hybridoma cell lines producing anti-Dsg3 antibody (5H10, 12A2) were developed as an in vitro model system for targeting B cells. Dsg3-GFP, a baculoprotein containing the entire extracellular domain of Dsg3 fused with green fluorescence protein, recognized and targeted the hybridoma cells through their surface immunoglobulin receptors in an antigen-specific way. The epitopes of these monoclonal antibodies were mapped on the amino terminal EC1 and part of EC2, a region considered functionally important in cadherins. Chimeric toxin molecules containing the mapped region (Dsg3ΔN1) and modified Pseudomonas exotoxin were produced in bacteria (Dsg3ΔN1-PE40-KDEL, PE37-Dsg3ΔN1-KDEL) and tested in vitro on hybridoma cell lines. The chimeric toxins, but not Dsg3ΔN1 alone, showed dose-dependent toxic activity with a reduction in hybridoma cell number to 40–60% of toxin-negative control cultures, compared with little or no effect on anti-Dsg3-negative hybridoma cells. Furthermore, these toxins showed toxic effects on anti-Dsg3 IgG-producing B cells from Dsg3ΔN1-immunized mice, with a 60% reduction in cell number compared with Dsg3ΔN1 alone. Thus, specific recognition and targeting of antigen-specific B cells in PV was demonstrated; this strategy may hold promise as a future therapeutic option for PV and other autoimmune diseases.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2133.2000.03328.x
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  • 5
    Digitale Medien
    Digitale Medien
    Two patients afflicted with both squamous cell carcinoma and Bowen's disease (2003)
    Oxford, UK : Blackwell Science Ltd
    Journal of the European Academy of Dermatology and Venereology 17 (2003), S. 0 
    Details
    ISSN: 1468-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1468-3083.2003.00614_8.x
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  • 6
    Digitale Medien
    Digitale Medien
    Mast cells in pseudo-Kaposi’s sarcoma lesions (2001)
    Oxford, UK : Blackwell Science Ltd
    Journal of the European Academy of Dermatology and Venereology 15 (2001), S. 0 
    Details
    ISSN: 1468-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1468-3083.2001.00327.x
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  • 7
    Digitale Medien
    Digitale Medien
    Allergic contact dermatitis due to crotamiton (2003)
    Oxford, UK; Malden , USA : Munksgaard International Publishers
    Contact dermatitis 49 (2003), S. 0 
    Details
    ISSN: 1600-0536
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.0105-1873.2003.0206h.x
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  • 8
    Digitale Medien
    Digitale Medien
    Meteorological Factors in the Epidemiology of Rice Blast (1975)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Phytopathology 13 (1975), S. 239-256 
    Details
    ISSN: 0066-4286
    Quelle: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft , Biologie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1146/annurev.py.13.090175.001323
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  • 9
    Digitale Medien
    Digitale Medien
    Identification of genes regulated by dark adaptation and far-red light illumination in roots of Arabidopsis thaliana (2004)
    Oxford, UK : Blackwell Science Ltd
    Plant, cell & environment 27 (2004), S. 0 
    Details
    ISSN: 1365-3040
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie
    Notizen: Roots in the soil are illuminated by far-red (FR) light passed through plant tissues in the daytime, and are in complete darkness at night. To evaluate whether gene expression of roots is affected by a dark-FR light cycle, gene expression profiles were analysed for dark-adapted versus light-grown plants and for FR light-illuminated versus dark-adapted plants using the RIKEN Arabidopsis full-length cDNA microarray (containing approximately 7000 independent, full-length cDNA groups). Among candidate dark- and FR-regulated genes, several were further analysed. Eleven dark-inducible and five dark-repressed genes were characterized. Almost all the dark-inducible and –repressed genes were oppositely regulated by FR light illumination. The functions of dark- and FR-responsive genes and the significance of FR light-regulated gene expression in roots under ground are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-3040.2004.01241.x
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  • 10
    Digitale Medien
    Digitale Medien
    Alkaline Phosphatase Isoenzymes in Carcinoma Tissue of Gastro-intestinal Tract (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 8 (1978), S. 0 
    Details
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The enzymological and immunological properties of alkaline phosphatase (ALP) isoenzymes in carcinoma tissues of the gastro-intestinal tract were compared with those of purified human intestinal, placental and hepatic ALP's to investigate the gene expression of gastro-intestinal cancer cells. The results were as follows: ALP obtained from carcinoma tissues of 77 patients was separated into 6 bands (ALPa, ALPb, ALPc, ALPd, ALPe and ALPf) by polyacrylamide-gel disc electrophoresis. It was concluded that ALPa was similar in its enzymological and immunological properties to hepatic-type ALP, ALPb was similar to placental-type ALP (Regan ALP or Nagao ALP), ALPc to intestinal-type ALP (metaplasia ALP), ALPd to hepatoma-type ALP (Warnock's variant ALP), ALPe to intestinal-type ALP except for electrophoretic mobility, and ALPf was similar to hepatic-type ALP except for neuraminidase sensitivity. ALPb appeared in 16 out of 55 cases (29%) of gastric carcinoma, and 2 out of 21 cases (10%) of colonic carcinoma. ALPd appeared in 4 out of 55 cases (7%). ALPe appeared in 2 out of 55 cases (4%) of gastric, and 3 out o 21 cases (14%) of colonic carcinoma. ALPf appeared in 1 out of 55 cases (2%) of gastric, and 1 out of 21 cases (5%) of colonic carcinoma. These ALP isoenzymes (ALPb, ALPd, ALPe and ALPf) probably originate from the cancer cells themselves and may represent an abnormal gene expression of cancer cells in the process of onco-developmental differentiation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-3083.1978.tb03977.x
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