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Digitale Medien

Development of a mouse-specific cDNA set for microarray gene expression analysis: differential gene expression in melanocyte lineage samples of the neural crest (1999)

Teichmann, U. ; Schuler, G. ; Moore, T. ; [weitere]

[s.l.] : Nature America, Inc.

Nature genetics 23 (1999), S. 78-78

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ISSN: 1546-1718

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] We are developing sets of mouse cDNAs with low redundancy for use in microarray analysis. The sets are based on sequence information from GenBank and the Washington University/Merck EST sequencing project. Related sequences from the non-redundant GenBank database were compared with mouse EST ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/14414

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Digitale Medien

Giant cell tumor of bone in a child (1999)

Otsuka, T. ; Yonezawa, M. ; Nishizaki, T. ; [weitere]

Springer

International journal of clinical oncology 4 (1999), S. 403-406

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ISSN: 1437-7772

Schlagwort(e): Key words Giant cell tumor ; Child ; Bone tumor

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Giant cell tumor (GCT) of bone was first established as a distinct clinicopathological radiographic entity in 1940 when Jaffe distinguished it from other lesions containing giant cells. GCT is rare in patients under 15 years of age. We report a case of GCT in a 10-year-old boy whose X-ray films showed osteolysis suggesting a malignant bone tumor. We believe this to be the youngest patient with giant cell bone tumor ever reported in the Japanese literature.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s101470050093

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Digitale Medien

Differential effects of interleukin-4 and interleukin-10 on nitric oxide production by murine macrophages (1999)

Nemoto, Y. ; Otsuka, T. ; Niiro, H. ; [weitere]

Springer

Inflammation research 48 (1999), S. 643-650

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ISSN: 1420-908X

Schlagwort(e): Key words: IL-4 — IL-10 — Peritoneal macrophage — Nitric oxide (NO)

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract. Objective: To study the effect of interleukin (IL)-4 and IL-10 on nitric oxide (NO) production by macrophages.¶Materials and Methods: Elicited or resident peritoneal macrophages (PMO) and a macrophage cell line Raw264.7 were primed by IL-4 or IL-10 for 6 hours, and were further incubated in the presence of interferon (IFN)-γ and/or lipopolysaccharide (LPS) for 48 hours. NO2 - accumulation in the supernatant of cultured cells was used as an indicator of NO production and was determined by the standard Griess reaction adapted for microplates. The amount of tumor necrosis factor (TNF)-α in the culture supernatants was determined with a commercially available ELISA kit. The absorbance was measured at 450 nm with a microplate photometer.¶Results: IL-4 inhibited NO production by murine macrophages of different sources and the macrophage cell line Raw264.7. In contrast, different macrophage populations showed differential responses to IL-10. After stimulation with LPS or IFN-γ, IL-10 suppressed NO production by elicited PMO but enhanced NO production by resident PMO or by Raw264.7. Both IL-4 and IL-10 inhibited the production of TNF-α, which has been shown to play a crucial role in NO production. In the presence or the absence of blocking antibody to TNF-α, IL-10 always enhanced NO production by resident PMO. This result suggests that the inhibition of TNF-α production and the enhancement of NO production by resident PMO stimulated with IL-10 are independent, coexisting events.¶Conclusions: Factors other than TNF-α have been suspected to influence NO production by macrophages, and this study indicates that IL-10 may be a candidate cytokine for resident PMO.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s000110050516

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