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  • 1990-1994  (3)
Datenquelle
Materialart
Erscheinungszeitraum
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  • 1
    Digitale Medien
    Digitale Medien
    The existence of filaments connecting the granules and the cell membrane in rat peritoneal mast cells (1991)
    Springer
    Inflammation research 33 (1991), S. 48-52 
    Details
    ISSN: 1420-908X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract SEM images of rat peritoneal mast cells showed that microtubule-like filament seemed to penetrate the granules and project several branches just beneath the granular surface. Each granule appeared to be a cluster of microgranules. TEM observations frequently revealed microtubules connecting the granule surface to the subplasmalemmal network or to the adjacent granule surface and on some occasions, microtubules also appeared to penetrate the granule membranes. Moreover, TEM revealed that individual granules seemed to consist of a mass of microgranules, each 10–15 nm in diameter; freeze-fracture images showed similar configurations. These findings suggest that the microtubule-like filamentous structures in mast cells play a role corresponding to that of the open canalicular system in platelets.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01993124
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Role of the cytoskeleton in Ca2+ release from the intracellular Ca store of rat peritoneal mast cells (1991)
    Springer
    Inflammation research 33 (1991), S. 44-47 
    Details
    ISSN: 1420-908X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In order to study the role of the cytoskeleton in histamine release from mast cells, the effects of cytochalasin D, cholchicine and vinblastine on Ca2+ release from the intracellular Ca store induced by compound 48/80 were investigated by means of a video-intensified microscopy system. When the quin 2-loaded mast cells were stimulated by 0.35 μg/ml of compound 48/80, a rapid increase in intracellular Ca2+ was observed. At concentrations higher than 10−6 M, both colchicine and vinblastine pretreatments significantly inhibited the increase in intracellular Ca2+ concentrations caused by compound 48/80, although cytochalasin D had no effect. When permeabilized mast cells were exposed to potassium-antimonate solution, microtubules became attached to the endoplasmic reticulum, where many dots of Ca-antimonate were observed; in some areas, the microtubules interconnected the endoplasmic reticulum and granules in the mast cells. From the results of the present study, it was assumed that microtubules play some important role in the processes leading to Ca2+ release from the intracellular Ca store.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01993123
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
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  • 3
    Digitale Medien
    Digitale Medien
    Histamine release induced by histone and related morphological changes in mast cells (1990)
    Springer
    Inflammation research 30 (1990), S. 114-117 
    Details
    ISSN: 1420-908X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract When isolated rat peritoneal mast cells were exposed to histone mixture, both histamine release and degranulation were evoked rapidly and dose-dependently at concentrations higher than 1 μg/ml in a Ca-free medium. All of the histone subfractions (H1, H2A, H2B, H3 and H4) induced histamine release from mast cells in a Ca-free medium and, as in the case of histone mixture, the amount of histamine release was reduced by addition of Ca2+. By means of high-voltage electron microscopy, at least three types of degranulation were observed in mast cells exposed to histone mixture: (1) microfilament-associated degranulation, (2) extrusion of granules with the surrounding membrane, and (3) mass degranulation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01969013
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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