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Digitale Medien

A non-invasive assessment of hepatic glycogen kinetics and post-absorptive gluconeogenesis in man (1994)

Gay, L. J. ; Schneiter, Ph. ; Schutz, Y. ; [weitere]

Springer

Diabetologia 37 (1994), S. 517-523

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ISSN: 1432-0428

Schlagwort(e): Key words Glycogen kinetics, gluconeogenesis, glycogenolysis, glucose metabolism in vivo, 13C glucose.

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary A novel approach to the study of hepatic glycogen kinetics and fractional gluconeogenesis in vivo is described. Ten healthy female subjects were fed an isocaloric diet containing 55 % carbohydrate energy with a 13C abundance of 1.083 atom percent for a 3-day baseline period; then, a diet of similar composition, but providing carbohydrate with a 13C abundance of 1.093 atom percent was started and continued for 5 days. Resting respiratory gas exchanges, urinary nitrogen excretion, breath 13CO2 and plasma 13C glucose were measured every morning in the fasting state. The enrichment in 13C of hepatic glycogen was calculated from these measured data. 13C glycogen enrichment increased after switching to a 13C enriched carbohydrate diet, and was identical to the 13C enrichment of dietary carbohydrates after 3 days. The time required to renew 50 % of hepatic glycogen, as determined from the kinetics of 13C glycogen enrichment, was 18.9±3.6 h. Fractional gluconeogenesis, as determined from the difference between the enrichments of glucose oxidized originating from hepatic glycogen and plasma glucose 13C was 50.8±5.3 %. This non-invasive method will allow the study of hepatic glycogen metabolism in insulin-resistant patients. [Diabetologia (1994) 37: 517–523]

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s001250050141

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Digitale Medien

Assessment of changes in body water by bioimpedance in acutely ill surgical patients (1992)

Chioléro, R. L. ; Gay, L. J. ; Cotting, J. ; [weitere]

Springer

Intensive care medicine 18 (1992), S. 322-326

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ISSN: 1432-1238

Schlagwort(e): Body water ; Bioimpedance

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Objective: To evaluate the relationship between changes in body bioelectrical impedance (BI) at 0.5, 50 and kHz and the changes in body weight, as an index of total body water changes, in acutely ill surgical patients during the rapid infusion of isotonic saline solution.Design: Prospective clinical study.Setting: Multidisciplinary surgical ICU in a university hospital.Patients: Twelve male patients treated for acute surgical illness (multiple trauman=5, major surgeryn=7). Selection criteria: stable cardiovascular parameters, normal cardiac function, signs of hypovolemia (CVP≤5 mmHg, urine ouput 〈1 ml/kg×h).Interventions: After baseline measurements, a 60 min fluid challenge test was performed with normal saline solution, 0.25 ml/kg.Measurements and results: Body weight (platform digital scale), total body impedance (four-surface electrode technique; measurements at 0.5, 50 and 100 kHz) and urine output. Fluid retention induced a progressive decrease in BI at 0.5, 50 and 100 kHz, but the changes were significant for BI 0.5 and BI 100 only, from 40 min after the beginning of the fluid therapy onwards. There was a significant negative correlation between changes in water retention and BI 0.5, with individual correlation coefficients ranging from −0.72 to 0.95 (p〈0.01–0.0001). The slopes of the regression lines indicated that for each kg of water change, there was a mean decrease in BI of 18 ohm, but a substantial inter-individual variability was noted.Conclusion: BI measured at low frequency can represent a valuable index of acute changes in body water in a group of surgical patients but not in a given individual

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01694359

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