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Digitale Medien

Differential response of human and rodent cell lines to chemical inhibition of the repair of potentially lethal damage (1989)

Little, J. B. ; Ueno, A. M. ; Dahlberg, W. K.

Springer

Radiation and environmental biophysics 28 (1989), S. 193-202

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Details

ISSN: 1432-2099

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Physik

Notizen: Summary We have examined the effects of several classes of metabolic inhibitors on the repair of potentially lethal damage in density-inhibited cultures of two rodent and two human cell systems which differ in their growth characteristics. Aphidicolin, 1-β-d-arabinofuranosylcytosine (ara-C) and hydroxyurea showed no effect on PLD repair, whereas the effects of 9-β-d-arabinofuranosyladenine (ara-A) and 3-aminobenzamide (3-AB) were cell line dependent. For example, 3-AB suppressed PLD repair almost completely in CHO cells, but showed no inhibitory effects in human diploid fibroblasts. These results indicate that inhibitors of DNA replication and poly(ADP-ribose) synthesis are not efficient inhibitors of cellular recovery in irradiated cells and, moreover, that such effects may be cell line dependent.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01211256

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