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  • 1
    Digitale Medien
    Digitale Medien
    Mutations in the unc-41 Gene Cause Elevation of Acetylcholine Levels (1994)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 63 (1994), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: Mutations in the Caenorhabditis elegans unc-41 gene result in an allele-dependent elevation of acetylcholine content. Eight recessive alleles (cn252, e268, e399, e650, e1175, e1199, e1294, and e870) lead to phenotypes including uncoordinated locomotion, slow growth, a small mature body, and resistance to the acetylcholinesterase inhibitors as well as the elevation of acetylcholine content. The remaining two alleles, e554 and e1162, exhibit normal acetylcholine levels but display the short-body phenotype in a semidominant way. To determine the localization of the elevated acetylcholine content, a method for the isolation of synaptic vesicles from C. elegans was established. The elevation of acetylcholine content in the unc-41 mutants is accompanied by the accumulation of synaptic vesicles. We propose that at least one function of the unc-41 gene relates to the release of neurotransmitters.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1471-4159.1994.63020439.x
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  • 2
    Digitale Medien
    Digitale Medien
    Construction of compact electron storage ring JSR : International conference on synchrotron radiation instrumentation (1989)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 60 (1989), S. 1724-1727 
    Details
    ISSN: 1089-7623
    Quelle: AIP Digital Archive
    Thema: Physik , Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: A compact electron storage ring (JSR) is under construction in order to study accelerator technologies and to be used as the test ring aiming at a highly brilliant synchrotron radiation facility (6–8 GeV). The JSR lattice is a double-focusing achromatic type. The circumference is 20.5 m. However, even in this small ring, one straight section with a length of ∼1.5 m, where the dispersion is free, is provided for the insertion device study. The electron beam is supplied by the linac with an energy of 150 MeV, and the stored energy is slowly increased up to 300 MeV. Power supplies of all magnets and the rf system are controlled by a real-time computer through optical fiber links, and signals of beam monitors are stored in the same computer so that it is easy to test any type of control procedures.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.1140939
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  • 3
    Digitale Medien
    Digitale Medien
    Neural and Behavioral Responses to Amino Acids in Mice and Rats (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 510 (1987), S. 0 
    Details
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1749-6632.1987.tb43551.x
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  • 4
    Digitale Medien
    Digitale Medien
    Binding of a non- β -lactam antibiotic to penicillin-binding proteins (1987)
    [s.l.] : Nature Publishing Group
    Nature 325 (1987), S. 179-180 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Lactivicin was produced by two strains of bacteria, YK-258 and YK-422, isolated from soil samples collected in Japan. It exists in aqueous solutions as an approximately 1:1 equilibrium mixture of two epimers (Fig. 1). The chemical properties and structural elucidation of lactivicin will be ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/325179a0
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  • 5
    Digitale Medien
    Digitale Medien
    Effect of HTLV-III on the macromolecular synthesis in HTLV-I carrying cell line, MT-4 (1986)
    Springer
    Medical microbiology and immunology 175 (1986), S. 325-334 
    Details
    ISSN: 1432-1831
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Upon infection of human T-cell leukemia virus type I (HTLV-I)-carrying human T-cell lines such as MT-4, HTLV-III, a probable etiologic agent of acquired immune deficiency syndrome (AIDS) caused fast and strong cytopathic effects leading ultimately to the death of the cells. Such effects were preceded by the rapid induction of HTLV-III antigens. Cell lines not infected with HTLV-I could, however, be subcultured after infection with HTLV-III, although they were also positive for HTLV-III antigens. To understand this cytopathogenicity of HTLV-III in HTLV-I bearing cells, macromolecular synthesis, including DNA synthesis and total protein synthesis, and also IL-2 receptor expression were investigated kinetically. In infected MT-4 cells DNA synthesis was markedly inhibited by HTLV-III after the HTLV-III antigen synthesis became evident. This inhibition occurred before cell damage was detected in terms of viable cell-growth, but after induction of HTLV-III antigen. Puromycin, at 40 Μg/ml, caused no toxic changes in MT-4 cells over 3 days but prevented viral antigen synthesis and virus-induced cytopathic effect. Protein synthesis and IL-2 receptor expression were also inhibited at 4 and 5 days post infection. The degree of the effects and their kinetics suggest that they are the secondary effects of cytotoxicity by HTLV-III infection.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02123869
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  • 6
    Digitale Medien
    Digitale Medien
    Matrix proteins regulate the proliferation of osteoblastic cells by affecting the actions of IGF-I (1993)
    Springer
    Osteoporosis international 3 (1993), S. 117-120 
    Details
    ISSN: 1433-2965
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01621883
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  • 7
    Digitale Medien
    Digitale Medien
    Crystal structure analysis of cytochrome c' by the multiwavelength anomalous diffraction method using synchrotron radiation (1986)
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 19 (1986), S. 448-452 
    Details
    ISSN: 1600-5767
    Quelle: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Thema: Geologie und Paläontologie , Physik
    Notizen: A multiwavelength X-ray diffraction study was performed at 6 Å resolution on the native cytochrome c′ crystal from Rhodospirillum rubrum, which contains heme irons. The X-ray intensity data from the crystal were collected on a four-circle diffractometer with three wavelengths, λ1 = 1.077, λ2 = 1.730 and λ3 = 1.757 Å, using the synchrotron radiation produced by the storage ring in the Photon Factory, National Laboratory for High Energy Physics. λ2 and λ3 are above and below the energy of the K absorption edge of iron (λe = 1.743 Å) respectively, while λ1 is far from the edge. The positions of the two iron atoms in the crystal could be determined from the difference Patterson maps based on either the real or imaginary components of the anomalous scattering effect caused by iron. The best phase angles for the crystal were calculated from the X-ray intensity data measured with λ1 and λ2 by the method which is basically the same as the isomorphous replacement method. Although the resulting best phase angles differed 75° on the average from those obtained by the multiple isomorphous replacement method, the molecular boundary and α helices could be recognized on the electron density map.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1107/S0021889886088970
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  • 8
    Digitale Medien
    Digitale Medien
    Refined crystal structure of pseudoazurin from Methylobacterium extorquens AM1 at 1.5 Å resolution (1994)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 50 (1994), S. 317-328 
    Details
    ISSN: 1399-0047
    Quelle: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Thema: Chemie und Pharmazie , Geologie und Paläontologie , Physik
    Notizen: The crystal structure of pseudoazurin from Methylobacterium extorquens AM1 (PAZAM1) has been solved by the molecular replacement method using copper–copper distances as translation parameters, which were obtained from difference Patterson maps calculated with the synchrotron radiation data containing the multiwavelength anomalous-dispersion effect. The structure refinement was carried out by the use of molecular dynamics optimization and the restrained least-squares method. The final crystallographic R factor was 19.9% for the 14 365 reflections greater than 3σ between 1.5 and 8.0 Å resolution. This report describes the characteristic features of the structure of PAZAM 1 as well as the effectiveness of synchrotron radiation for structure analysis of metalloproteins. The environment of the metal active site and the structural differences among blue-copper proteins are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1107/S0907444994000260
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  • 9
    Digitale Medien
    Digitale Medien
    Increased contact hypersensitivity response in mice by topical application of 1α,25-dihydroxyvitamin D3 to elicitation site (1989)
    Springer
    Archives of dermatological research 281 (1989), S. 355-361 
    Details
    ISSN: 1432-069X
    Schlagwort(e): 1α,25-Dihydroxyvitamin D3 ; Vitamin D3 ; Contact hypersensitivity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Recent evidence indicates that the biologically active metabolite of vitamin D3, 1α,25-dihydroxy-vitamin D3 [1α,25(OH)2D3], has an effect on the regulation of the immune response. We investigated whether topical treatment of mice with 1α,25(OH)2D3 influences the contact hypersensitivity (CHS) response to trinitrochlorobenzene (TNCB). 1α,25(OH)2D3 was applied to the dorsal trunk of A/J mice on days 0–3, and on day 4 topical application of 5% TNCB on the 1α,25(OH)2D3-treated site was performed. The mice were tested for CHS on day 10 by applying 1% TNCB to the ears. No effect on induction of CHS response to TNCB was observed in 1α,25(OH)2D3-treated mice compared with 24,25-dihydroxyvitamin D3[24,25-(OH)2D3]-treated mice as control. In a second experiment, the dorsal trunk of A/J mice was treated with 5% TNCB on day 0. The topical application of 1α,25(OH)2D3 on the ears was performed from days 2 to 5. On day 6, the mice were tested for CHS by applying 1% TNCB to the 1α,25(OH)2D3-treated ears. When 1α,25(OH)2D3 increased their response to TNCB by 40% compared with 24,25(OH)2D3-treated mice as 1α,25(OH)2D3 increased their response to TNCB by 40% compared with 24,25(OH)2D3-treated mice as control (P〈0.01). There were no findings suggesting that the pretreatment of the challenge site with 1α,25(OH)2D3 induced an irritant dermatitis that was superimposed on a subsequent CHS reaction. The 1α,25(OH)2D3 modulation of CHS response to TNCB in mice suggests that the hormone may play a role in the regulation of the immune response in vivo.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00412982
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  • 10
    Digitale Medien
    Digitale Medien
    Two sulfur-containing ansamycin antibiotics fromStreptomyces albolongus (1986)
    Springer
    Cellular and molecular life sciences 42 (1986), S. 1167-1170 
    Details
    ISSN: 1420-9071
    Schlagwort(e): Ansamycin ; ansathiazin ; awamycin ; Streptomyces albolongus C-46366 ; gram-positive bacteria
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Two sulfur-containing ansamycin antibiotics were isolated from the culture broth ofStreptomyces albolongus C-46366; the major one was identical with awamycin and the minor one was a new ansamycin antibiotic, ansathiazin. Their structures were elucidated from their reactions and spectroscopic analyses. These antibiotics were active against gram-positive bacteria, acid-fast bacteria and a protozoan.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01941296
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