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  • 1975-1979  (18)
  • 1970-1974  (1)
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  • 1
    Digitale Medien
    Digitale Medien
    Increase in choline acetyltransferase activity in the nervous system of adult frogs awakened from hibernation (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 32 (1979), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1979.tb02304.x
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  • 2
    Digitale Medien
    Digitale Medien
    SUBCELLULAR DISTRIBUTION AND SOME PROPERTIES OF ACETYL-COENZYME A HYDROLASE IN THE BRAIN (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 26 (1976), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: —The detailed subcellular distribution and some properties of acetyl-CoA hydrolase were studied in the rat brain. The brain homogenate (S1) hydrolysed acetyl-CoA at a rate of approx 2·3 nmol/min/mg of protein at 37°C. The total activity of acetyl-CoA hydrolase was distributed in the following order: soluble 〉 mitochondrial 〉 microsomal, synaptosomal 〉 myelin fraction. The order of the specific activity of the enzyme was: soluble, microsomal 〉 mitochondrial 〉 synaptosomal 〉 myelin fraction. The synaptic vesicle fraction (D) had relatively high specific activity among the intraterminal particulate fractions, having two or three times higher specific activity than that of the synaptic cytoplasmic membrane fraction (F or G). Attempts to de-occlude acetyl-CoA hydrolase in the particulate fraction showed that only the enzyme activity in the myelin fraction was increased markedly by the treatment with ether or Triton X-100. Lineweaver-Burk plots gave straight lines for each subcellular fraction and apparent Km values for acetyl-CoA were between 0·1 and 0·2 mM. Neither diisopropyl fluorophosphate nor physostigmine at the concentration of 0·1 mm inhibited the enzyme activity.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1976.tb04456.x-i1
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  • 3
    Digitale Medien
    Digitale Medien
    FACTORS REQUIRED FOR Ca-SENSITIVE ACETYLCHOLINE RELEASE FROM CRUDE SYNAPTIC VESICLES (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 27 (1976), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract— Studies were made on intracellular factors required for the release of ACh from crude synaptic vesicles prepared from rat brain. A factor stimulating ACh release in the presence of calcium ions was found in the cell sap.Cell sap obtained by hypotonic shock of a crude mitochondrial fraction stimulated ACh release from the synaptic vesicles in the presence of ATP and magnesium ions. Calcium ions were essential for its effect and the optimum concentration of calcium was about 10−4m. The stimulatory factor in cell sap passed through a cellulose or collodion membrane or ultrafiltration membrane UM 10, but not through that of an ultrafiltration membrane UM 05. The factor was not affected by trypsin or α-chymotrypsin, but was inactivated by pronase or carboxypeptidase-A. Thus it seemed to be a peptide-like substance with a rather low molecular weight. Cyclic-AMP, cyclic-GMP, colchicine and vinblastne did not affect ACh release under our experimental conditions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1976.tb01555.x
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  • 4
    Digitale Medien
    Digitale Medien
    STUDIES ON SOLUBLE PROTEINS RELEASED FROM THE SYNAPTIC VESICLES OF RAT BRAIN CORTEX (1971)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 18 (1971), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract— The soluble proteins released from the synaptic vesicles of rat cerebral cortex were studied. One fraction (D4) of these proteins was released in parallel with release of acetylcholine when synaptic vesicles were incubated at 37°C for 10 min in isotonic medium. Another fraction (Dj) was liberated from synaptic vesicles when their membranes were ruptured by mild treatment under hyposmotic conditions and freeze-thawing after release of D1 fraction. Fractions D1 and D2 contained 12 and 9 per cent, respectively, of the total protein in the synaptic vesicles. Some properties of these fractions were investigated by zone electrophoresis and ultracentrifugation, and by measuring their binding capacities for [14C]acetylcholine and various enzyme activities related to acetylcholine metabolism.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1971.tb12001.x
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  • 5
    Digitale Medien
    Digitale Medien
    STIMULATION OF BRAIN ACETYL-CoA HYDROLASE BY ATP AND ATP ANALOGUES (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 30 (1978), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The effects of ATP and ATP analogues on the brain acetyl-CoA hydrolase (EC 3.1.2.1) were studied. The enzyme was stimulated reversibly by ATP-Mg2+ the presence of Mg2+ being absolutely required for the stimulation. The stimulatory effect of ATP was highly specific since adenine nucleotides other than ATP had no stimulatory effects and nucleoside triphosphates other than ATP stimulated the enzyme much less than ATP in the following order: ATP 〉 ITP CTP, UTP GTP. A phosphate modified analogue of ATP, AMP-PNP had a similar stimulatory effect to that of ATP. Other ATP analogues such as AMP-PCP and AMPCPP showed less stimulatory effect than ATP. The order of the stimulatory effects of these ATP analogues was: ATP 〉 AMP-PNP 〉 AMP-PCP 〉 AMPCPP. The concentrations needed for half-maximal stimulation of ATP, AMP-PNP and AMP-PCP were approx 0.11 mm, 0.22 mm, and 0.22 mm, respectively. Double reciprocal plots demonstrated that ATP as well as AMP-PNP produced a significant decrease in the apparent Km, value for acetyl-CoA and an increase in Vmax indicating that these nucleotides increased the affinity for acetyl-CoA through binding at a site other than the catalytic site. The data described above suggest that the rate of hydrolysis of acetyl-CoA may be regulated by the concentration of ATP in the micro-environment of the enzyme.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1978.tb07043.x
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  • 6
    Digitale Medien
    Digitale Medien
    The polymerization of α-aminopropionitrile (1977)
    Springer
    Origins of life and evolution of the biospheres 8 (1977), S. 341-346 
    Details
    ISSN: 1573-0875
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Geologie und Paläontologie
    Notizen: Abstract The mixture of α-aminopropionitrile and α,α′-iminodipropionitrile polymerized to solidify almost at the temperature near 0°C during 8 years. The conversions based on decreasing of those reactants were 61 and 98% at 4 and 8 years, respectively. The fractionation of 4 and 8 years product using Sephadex G 10 yielded their predominant amounts in the oligomer and polymer section, respectively. The oligomer section product of 8 years product was analyzed by means of ion exchange chromatography and its trimethylsilyl derivative was also analyzed by means of gas chromatography combined with mass spectrometry. These results identified dialanine and trialanine and their amides and nitriles.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00927904
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  • 7
    Digitale Medien
    Digitale Medien
    The synthesis and chromatography of peptide nitriles (1977)
    Springer
    Origins of life and evolution of the biospheres 8 (1977), S. 347-353 
    Details
    ISSN: 1573-0875
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Geologie und Paläontologie
    Notizen: Abstract Di- and tripeptide nitriles, glycylaminoacetonitrile (Gly-AAN), diglycylaminoacetonitrile (Gly-Gly-AAN), alanyl-α-aminopropionitrile (Ala-APN), and dialanyl-α-aminopropionitrile (Ala-Ala-APN) were synthesized first. These peptide nitriles and related peptides and peptide amides were analyzed by means of ion-exchange chromatography. The every two diastereomers of dialanine, dialanine amide, and Ala-APN were separated into two peaks by using a pH 3.25 buffer as an eluent. The four isomers of trialanine, trialanine amide, and Ala-Ala-APN gave four, two, and one peak, respectively under the same conditions. The trimethylsilyl derivatives of alanyl peptides and related compounds were analyzed by means of gas chromatography combined with mass-spectrometry. The parent (M+ and/or M+-15) and other mass numbers observed in their mass-spectra supported the introduction of various numbers of trimethylsilyl groups.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00927905
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  • 8
    Digitale Medien
    Digitale Medien
    The asymmetric adsorption of α-aminopropionitrile on D-quartz (1977)
    Springer
    Origins of life and evolution of the biospheres 8 (1977), S. 355-360 
    Details
    ISSN: 1573-0875
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Geologie und Paläontologie
    Notizen: Abstract α-Aminopropionitrile was adsorbed on the powdered D-quartz, recovered as N-trifluoroacetylalanyl-(+)-secondarybutyl ester, and analyzed by means of gas chromatography. The asymmetric result supporting the preferential adsorption of L-antipode was obtained and its significance in chemical evolution has been discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00927906
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  • 9
    Digitale Medien
    Digitale Medien
    Trans-4-hydroxy-3-methoxycinnamic acid (ferulic acid) inhibits the effect of androgens on the rat prostate (1979)
    Springer
    Cellular and molecular life sciences 35 (1979), S. 696-699 
    Details
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Trans-4-hydroxy-3-methoxycinnamic acid (ferulic acid, FA) antagonized the effect of exogenous androgens on the ventral prostate (VP) in castrated rats as well as the effect of endogenous androgens in intact rats. FA, however, had no effect on the seminal vesicles (SV) and levator ani muscle (LAM), nor oestrogenic effect in female rats and mice. FA did not antagonize the receptor binding of testosterone nor inhibit the conversion of testosterone into 5α-dihydrotestosterone (DHT).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01960405
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  • 10
    Digitale Medien
    Digitale Medien
    Properties of vascular permeability factor in human sera for guinea-pig skin (1979)
    Springer
    Cellular and molecular life sciences 35 (1979), S. 676-678 
    Details
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Properties of vascular permeability factor in native human sera (PF/Nat) showed close similarities with those of necrotizing factor. Time course studies revealed that skin necrosis could be initiated by enhanced vascular permeability.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01960394
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