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  • 1
    Digitale Medien
    Digitale Medien
    Increase in the slow inward current by intracellularly applied nifedipine and nicardipine in single ventricular cells of the guinea-pig heart
    Amsterdam : Elsevier
    Journal of Molecular and Cellular Cardiology 16 (1984), S. 1173-1177 
    Details
    ISSN: 0022-2828
    Schlagwort(e): Adenosine 3',5'-cyclic monophosphate phosphodiesterase ; Dihydropyridine calcium antagonist ; Slow inward current
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1016/S0022-2828(84)80043-7
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Inhibition of the slow inward current and the time-dependent outward current of mammalian ventricular muscle by gentamicin (1982)
    Springer
    Pflügers Archiv 394 (1982), S. 243-249 
    Details
    ISSN: 1432-2013
    Schlagwort(e): Papillary muscle ; Gentamicin ; Slow inward current ; Calcium ; Time-dependent outward current
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The aminoglycoside antibiotic, gentamicin (GM), depressed the plateau phase and shortened the duration of the action potential in guinea pig papillary muscle. Its effect on the membrane currents was studied by a single sucrose gap voltage clamp method. The slow inward current (is) was remarkably diminished by GM with little change in its time course, in the voltage-dependency of the steady-state inactivation and activation or in its reversal potential. The maximal amplitude of is, obtained by subtracting the Co2+-resistant current, was reduced to 57% by 0.1 mmol/l GM and almost reduced to zero by 1 mmol/l GM. The efficacy of GM in inhibiting is was reduced by increasing the external Ca2+ concentration from 1.8 to 5.4 or 10.8 mmol/l, but not by the application of adrenaline. The time-dependent outward current (iK) was also decreased by GM but only at higher concentrations. It is proposed that the depressant action of GM on is was due to a blockade of slow channels, whereby GM may have dislocated Ca from the binding sites at slow channels on the external surface of the membrane.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00589099
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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